PLA2G5 - phospholipase A2 group V Gene

Also Known as FRFB; GV-PLA2; PLA2-10; hVPLA(2)

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5322

About PLA2G5

Cytogenetic location: 1p36.13 Genomic coordinates (GRCh38): 1:20,028,408-20,091,911 (from NCBI)

This gene has 8 transcripts (splice variants), 116 orthologues, 8 paralogues and is associated with 3 phenotypes. Biased expression in heart (RPKM 14.5), ovary (RPKM 8.6) and 8 other tissues.

Summary

This gene is a member of the secretory Phospholipase A2 family. It is located in a tightly-linked cluster of secretory Phospholipase A2 genes on chromosome 1. The encoded enzyme catalyzes the hydrolysis of membrane Phospholipids to generate lysophospholipids and free fatty acids including arachidonic acid. It preferentially hydrolyzes linoleoyl-containing phosphatidylcholine substrates. Secretion of this enzyme is thought to induce inflammatory responses in neighboring cells. Alternatively spliced transcript variants have been found, but their full-length nature has not been determined. [provided by RefSeq, Jul 2008]

PLA2G5 Products (1)

mRNA Protein Name
NM_000929.3 NP_000920.1 phospholipase A2 group V precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium-independent phospholipase A2 activity IDA
IDA: Inferred from direct assay
23533611 GOA
Biological Process GO Annotation Evidence References Source
involved in cardiolipin acyl-chain remodeling IDA
IDA: Inferred from direct assay
23533611 GOA
involved in leukotriene biosynthetic process IDA
IDA: Inferred from direct assay
20432503 GOA
involved in phosphatidylcholine catabolic process IDA
IDA: Inferred from direct assay
23533611 GOA
involved in positive regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
22837859 GOA
involved in positive regulation of immune complex clearance by monocytes and macrophages IDA
IDA: Inferred from direct assay
20432503 GOA
involved in positive regulation of phospholipase activity IDA
IDA: Inferred from direct assay
22837859 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLA2G5 Protein Structure

Phospholip_A2_1

Phospholip_A2_1: Phospholipase A2 (22 - 132)

  • 0
  • 100
  • 138 a.a.
Protein Preferred Names Protein Names

phospholipase A2 group V

  • Ca2+-dependent phospholipase A2

Related Diseases

Diseases Alias
Fleck Retina, Familial Benign

  • FRFB

  • Familial Benign Flecked Retina

  • Familial Benign Fleck Retina
Late-Onset Retinal Degeneration

  • LORD

  • Retinal Degeneration, Late-Onset, Autosomal Dominant

  • Autosomal Dominant Late-Onset Retinal Degeneration

  • Pigmentary Retinopathy

  • Retinal Degeneration, Late-Onset

  • Retinitis Pigmentosa
Alcoholic Gastritis

  • Alcoholic Gastritis, With Hemorrhage

  • Alcoholic Gastritis, Without Mention Of Hemorrhage

  • Alcohol Gastritis

  • Etoh Gastritis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10632 PLA2G5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-184012 BAY-163 Control / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus PLA2G5 VGNC VGNC:32963
Felis catus PLA2G5 VGNC VGNC:68882
Mus musculus PLA2G5 MGD MGI:101899
Canis familiaris PLA2G5 VGNC VGNC:44630
Rattus norvegicus PLA2G5 RGD RGD:62051
Others PLA2G5 NCBI