Ric8a - RIC8 guanine nucleotide exchange factor A Gene

Rattus norvegicus

Also known as Ric8; Ric-8A

Gene ID: 293614 | Gene type: protein coding

About Ric8a

Summary

Enables G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Located in cytoplasm and plasma membrane. Orthologous to human RIC8A (RIC8 guanine nucleotide exchange factor A). [provided by Alliance of Genome Resources, Apr 2022]

Ric8a Products(1)

mRNA	Protein	Name
NM_001100520.1	NP_001093990.1	synembryn-A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables G-protein alpha-subunit binding	IDA IDA: Inferred from direct assay	12509430	RGD
enables G-protein alpha-subunit binding	IPI IPI: Inferred from physical interaction	12509430	RGD
enables GTPase activator activity	IDA IDA: Inferred from direct assay	12509430	RGD
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	12509430	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21158412	RGD
enables protein folding chaperone	IDA IDA: Inferred from direct assay	31155309	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	31155309	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	21158412	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	21158412	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

synembryn-A

heterotrimeric G protein guanine nucleotide exchange factor Ric-8A	resistance to inhibitors of cholinesterase 8 homolog
resistance to inhibitors of cholinesterase 8A	resistance to inhibitors of cholinesterase 8A-like protein
synembryn

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-122579	IGS-1.76	Inhibitor	98.57%	Unkown
HY-RS11967	RIC8A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-121503	FD44		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ric8a	NCBI	NCBI:60626

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