2. Gene
  3. RIC8A - RIC8 guanine nucleotide exchange factor A Gene

RIC8A - RIC8 guanine nucleotide exchange factor A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as RIC8

Gene ID: 60626 | Gene type: protein coding

About RIC8A

Cytogenetic location: 11p15.5 Genomic coordinates (GRCh38): 11:207,708-215,113 (from NCBI)

This gene has 17 transcripts (splice variants), 187 orthologues and 1 paralogue. Ubiquitous expression in testis (RPKM 20.2), brain (RPKM 15.3) and 25 other tissues.

Summary

Predicted to enable G-protein alpha-subunit binding activity; GTPase activator activity; and guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to act upstream of or within several processes, including basement membrane organization; gastrulation; and visual learning. Predicted to be located in membrane. Predicted to be active in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RIC8A Products(4)

mRNA Protein Name
NM_001286134.2 NP_001273063.1 synembryn-A isoform 2
NM_001386941.1 NP_001373870.1 synembryn-A isoform 3
NM_001386942.1 NP_001373871.1 synembryn-A isoform 4
NM_021932.6 NP_068751.4 synembryn-A isoform 1

RIC8A Protein Structure

Ric8

Ric8: Guanine nucleotide exchange factor synembryn (66 - 498)

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  • 531 a.a.
Protein Preferred Names Protein Names

synembryn-A

resistance to inhibitors of cholinesterase 8 homolog A

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-122579 IGS-1.76 Inhibitor 98.56% Unkown
HY-RS11967 RIC8A Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RIC8A MGD MGI:2141866
Macaca mulatta RIC8A VGNC VGNC:76863
Rattus norvegicus RIC8A RGD RGD:727957
Canis familiaris RIC8A VGNC VGNC:45572
Felis catus RIC8A VGNC VGNC:64624
Bos taurus RIC8A VGNC VGNC:33961