Adra1a - adrenoceptor alpha 1A Gene

Also Known as Adra1c

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29412

Summary

Enables alpha1-adrenergic receptor activity. Involved in several processes, including activation of Phospholipase C activity; positive regulation of cell communication; and regulation of blood circulation. Acts upstream of or within negative regulation of Rho protein signal transduction. Located in T-tubule and Z disc. Is active in GABA-ergic synapse; dopaminergic synapse; and glutamatergic synapse. Is integral component of postsynaptic membrane and integral component of presynaptic membrane. Used to study bladder neck obstruction. Biomarker of hypertension and polycystic ovary syndrome. Human ortholog(s) of this gene implicated in Alzheimer's disease and hypertension. Orthologous to human ADRA1A (adrenoceptor alpha 1A). [provided by Alliance of Genome Resources, Apr 2022]

Adra1a Products (1)

mRNA Protein Name
NM_017191.2 NP_058887.2 alpha-1A adrenergic receptor

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of Rho protein signal transduction IMP
IMP: Inferred from mutant phenotype
18332105 RGD
involved in phospholipase C-activating adrenergic receptor signaling pathway IMP
IMP: Inferred from mutant phenotype
19011682 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
19011682 RGD
involved in positive regulation of action potential IMP
IMP: Inferred from mutant phenotype
17337632 RGD
involved in positive regulation of cardiac muscle contraction IMP
IMP: Inferred from mutant phenotype
19011682 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: Inferred from mutant phenotype
17588332 RGD
involved in positive regulation of heart rate IMP
IMP: Inferred from mutant phenotype
22040923 RGD
involved in positive regulation of protein kinase C signaling IDA
IDA: Inferred from direct assay
18467629 RGD
involved in positive regulation of smooth muscle contraction IMP
IMP: Inferred from mutant phenotype
19041301 RGD
involved in positive regulation of synaptic transmission, GABAergic IDA
IDA: Inferred from direct assay
14532911 RGD
involved in positive regulation of systemic arterial blood pressure IMP
IMP: Inferred from mutant phenotype
22040923 RGD
involved in positive regulation of vasoconstriction IDA
IDA: Inferred from direct assay
15877108 RGD
involved in positive regulation of vasoconstriction IMP
IMP: Inferred from mutant phenotype
19011682 RGD
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: Inferred from Experiment
12548707 RGD
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: Inferred from direct assay
12548707 RGD
involved in response to hormone IMP
IMP: Inferred from mutant phenotype
11684150 RGD
involved in response to xenobiotic stimulus IMP
IMP: Inferred from mutant phenotype
17588332 RGD
Cellular Component GO Annotation Evidence References Source
is active in GABA-ergic synapse IDA
IDA: Inferred from direct assay
22588352 RGD
located in T-tubule IDA
IDA: Inferred from direct assay
18467629 RGD
located in Z disc IDA
IDA: Inferred from direct assay
18467629 RGD
is active in dopaminergic synapse IDA
IDA: Inferred from direct assay
22588352 RGD
is active in glutamatergic synapse EXP
EXP: Inferred from Experiment
12548707 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
12548707 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
22588352 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
22588352 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

alpha-1A adrenergic receptor

  • adrenergic alpha 1c receptor

  • adrenergic receptor alpha 1c subtype

  • adrenergic receptor, alpha 1a

  • adrenergic receptor, alpha 1c

  • adrenergic, alpha-1A-, receptor

  • alpha-1A adrenoceptor

  • alpha-1A adrenoreceptor

  • alpha-1C adrenergic receptor

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00408 ADRA1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS00410 ADRA1D Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21088 Adra1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27606 Adra1a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Adra1a NCBI NCBI:148