Rap1a - RAP1A, member of RAS oncogene family Gene

Also Known as RAP-1A; rap 1A

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 295347

Summary

Enables GTP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular response to cAMP; liver regeneration; and positive regulation of signal transduction. Located in cytoplasmic vesicle and perinuclear region of cytoplasm. Orthologous to human RAP1A (RAP1A, member of Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rap1a Products (1)

mRNA Protein Name
NM_001005765.1 NP_001005765.1 ras-related protein Rap-1A

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTP binding IDA
IDA: Inferred from direct assay
20339002 RGD
enables guanyl-nucleotide exchange factor activity IMP
IMP: Inferred from mutant phenotype
17724123 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
16436672 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
20339002 RGD
involved in cellular response to nerve growth factor stimulus IDA
IDA: Inferred from direct assay
17724123 RGD
involved in cellular response to nerve growth factor stimulus IEP
IEP: Inferred from expression pattern
17822405 RGD
involved in cellular response to organic cyclic compound IDA
IDA: Inferred from direct assay
10908723 RGD
involved in cellular response to xenobiotic stimulus IDA
IDA: Inferred from direct assay
10908723 RGD
involved in liver regeneration IEP
IEP: Inferred from expression pattern
9015365 RGD
involved in negative regulation of collagen biosynthetic process IMP
IMP: Inferred from mutant phenotype
22012077 RGD
involved in nerve growth factor signaling pathway IDA
IDA: Inferred from direct assay
17724123 RGD
involved in positive regulation of D-glucose import IMP
IMP: Inferred from mutant phenotype
17450172 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
17724123 RGD
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway IMP
IMP: Inferred from mutant phenotype
18832707 RGD
involved in positive regulation of GTPase activity IMP
IMP: Inferred from mutant phenotype
17724123 RGD
involved in positive regulation of neuron projection development IMP
IMP: Inferred from mutant phenotype
17724123 RGD
involved in positive regulation of phagocytosis IMP
IMP: Inferred from mutant phenotype
18832707 RGD
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
17724123 RGD
involved in response to antineoplastic agent IDA
IDA: Inferred from direct assay
17822405 RGD
involved in response to carbohydrate IEP
IEP: Inferred from expression pattern
9149109 RGD
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
17724123 RGD
located in early endosome IDA
IDA: Inferred from direct assay
17724123 RGD
located in late endosome IDA
IDA: Inferred from direct assay
17724123 RGD
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
17724123 RGD
located in phagocytic vesicle IDA
IDA: Inferred from direct assay
18832707 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ras-related protein Rap-1A

  • RAS-related protein 1a

  • ras-related protein Krev-1

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-16322 Minodronic acid 99.67% Unkown

Pre-clinical Phase

Bioactive Molecules (13)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-15871 GGTI298 Trifluoroacetate Inducer 99.87% Unkown
HY-123242 FTI-2153 Inhibitor 99.77% Unkown
HY-12369 GGTI-2133 Inhibitor 98.50% Unkown
HY-115489A GGTI-286 TFA Inhibitor / Unkown
HY-115489 GGTI-286 Inhibitor / Unkown
HY-100876 GGTI298 Inducer / Unkown
HY-117935 GGTI-286 hydrochloride Inhibitor / Unkown
HY-123242A FTI-2153 TFA Inhibitor 99.11% Unkown
HY-RS16300 Rap1a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120229 GGTI-2147 Inhibitor / Unkown
HY-12369A GGTI-2133 TFA Inhibitor / Unkown
HY-RS11652 RAP1A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-120271 GGTI-297 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Rap1a NCBI NCBI:5906