Rap1a - RAP1A, member of RAS oncogene family Gene

Rattus norvegicus

Also known as RAP-1A; rap 1A

Gene ID: 295347 | Gene type: protein coding

About Rap1a

Summary

Enables GTP binding activity and guanyl-nucleotide exchange factor activity. Involved in several processes, including cellular response to cAMP; liver regeneration; and positive regulation of signal transduction. Located in cytoplasmic vesicle and perinuclear region of cytoplasm. Orthologous to human RAP1A (RAP1A, member of Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Rap1a Products(1)

mRNA	Protein	Name
NM_001005765.1	NP_001005765.1	ras-related protein Rap-1A

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GTP binding	IDA IDA: Inferred from direct assay	20339002	RGD
enables guanyl-nucleotide exchange factor activity	IMP IMP: Inferred from mutant phenotype	17724123	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	16436672	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	20339002	RGD
involved in cellular response to nerve growth factor stimulus	IDA IDA: Inferred from direct assay	17724123	RGD
involved in cellular response to nerve growth factor stimulus	IEP IEP: Inferred from expression pattern	17822405	RGD
involved in cellular response to organic cyclic compound	IDA IDA: Inferred from direct assay	10908723	RGD
involved in cellular response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	10908723	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	9015365	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	22012077	RGD
involved in nerve growth factor signaling pathway	IDA IDA: Inferred from direct assay	17724123	RGD
involved in positive regulation of D-glucose import	IMP IMP: Inferred from mutant phenotype	17450172	RGD
involved in positive regulation of ERK1 and ERK2 cascade	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in positive regulation of Fc receptor mediated stimulatory signaling pathway	IMP IMP: Inferred from mutant phenotype	18832707	RGD
involved in positive regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in positive regulation of neuron projection development	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in positive regulation of phagocytosis	IMP IMP: Inferred from mutant phenotype	18832707	RGD
involved in positive regulation of protein kinase activity	IMP IMP: Inferred from mutant phenotype	17724123	RGD
involved in response to antineoplastic agent	IDA IDA: Inferred from direct assay	17822405	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	9149109	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	17724123	RGD
located in early endosome	IDA IDA: Inferred from direct assay	17724123	RGD
located in late endosome	IDA IDA: Inferred from direct assay	17724123	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	17724123	RGD
located in phagocytic vesicle	IDA IDA: Inferred from direct assay	18832707	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

ras-related protein Rap-1A

RAS-related protein 1a

ras-related protein Krev-1

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16322	Minodronic acid		99.67%	Unkown

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15871	GGTI298 Trifluoroacetate	Inducer	99.87%	Unkown
HY-123242	FTI-2153	Inhibitor	99.77%	Unkown
HY-12369	GGTI-2133	Inhibitor	98.50%	Unkown
HY-115489A	GGTI-286 TFA	Inhibitor	/	Unkown
HY-115489	GGTI-286	Inhibitor	/	Unkown
HY-100876	GGTI298	Inducer	/	Unkown
HY-117935	GGTI-286 hydrochloride	Inhibitor	/	Unkown
HY-123242A	FTI-2153 TFA	Inhibitor	99.11%	Unkown
HY-RS16300	Rap1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120229	GGTI-2147	Inhibitor	/	Unkown
HY-12369A	GGTI-2133 TFA	Inhibitor	/	Unkown
HY-RS11652	RAP1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120271	GGTI-297	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Rap1a	NCBI	NCBI:5906

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