2. Gene
  3. Capzb - capping actin protein of muscle Z-line subunit beta Gene

Capzb - capping actin protein of muscle Z-line subunit beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 298584 | Gene type: protein coding

About Capzb

Summary

Predicted to enable actin filament binding activity and beta-tubulin binding activity. Predicted to be involved in several processes, including barbed-end actin filament capping; regulation of cell morphogenesis; and regulation of plasma membrane bounded cell projection assembly. Predicted to act upstream of or within several processes, including actin polymerization or depolymerization; negative regulation of microtubule polymerization; and plasma membrane bounded cell projection organization. Located in dendritic spine and neuronal cell body. Biomarker of dementia. Orthologous to human CAPZB (capping actin protein of muscle Z-line subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

Capzb Products(1)

mRNA Protein Name
NM_001005903.1 NP_001005903.1 F-actin-capping protein subunit beta
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15845376 RGD
Cellular Component GO Annotation Evidence Reference Source
located in dendritic spine IDA
IDA: Inferred from direct assay
20545768 RGD
located in neuronal cell body IDA
IDA: Inferred from direct assay
15845376 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-actin-capping protein subunit beta

F-actin capping protein beta subunit

capZ beta

capping actin protein of muscle Z-line beta subunit

capping protein (actin filament) muscle Z-line, beta

Capzb Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
Capzb Q5XI32 Mtpn Rattus norvegicus P62775
Anti Bait CoIP
15845376
Intra
Capzb Q5XI32 Mtpn Rattus norvegicus P62775
Confocal
15845376
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS01904 CAPZB Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Capzb NCBI NCBI:832