Mtpn - myotrophin Gene

Also Known as Gcdp

Species: Rattus norvegicus

Gene Type: protein coding

Gene ID: 79215

Summary

Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to mechanical stimulus; cerebellar granule cell differentiation; and regulation of macromolecule biosynthetic process. Located in axon; cytosol; and nucleus. Used to study hypertension. Biomarker of hypertension. Orthologous to human MTPN (myotrophin). [provided by Alliance of Genome Resources, Apr 2022]

Mtpn Products (1)

mRNA	Protein	Name
NM_024374.4	NP_077350.1	myotrophin

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15845376	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12031792	RGD

Biological Process GO Annotation	Evidence	References	Source
involved in catecholamine metabolic process	IEP IEP: Inferred from expression pattern	12051753	RGD
involved in cellular response to mechanical stimulus	IEP IEP: Inferred from expression pattern	12031792	RGD
involved in cerebellar granule cell differentiation	IEP IEP: Inferred from expression pattern	8144589	RGD
involved in positive regulation of NF-kappaB transcription factor activity	IDA IDA: Inferred from direct assay	18693253	RGD
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	18693253	RGD
involved in positive regulation of cell growth	IDA IDA: Inferred from direct assay	18693253	RGD
involved in positive regulation of macromolecule biosynthetic process	IDA IDA: Inferred from direct assay	18693253	RGD
involved in positive regulation of protein metabolic process	IDA IDA: Inferred from direct assay	18693253	RGD
involved in skeletal muscle tissue regeneration	IEP IEP: Inferred from expression pattern	12467730	RGD
involved in striated muscle cell differentiation	IEP IEP: Inferred from expression pattern	12467730	RGD

Cellular Component GO Annotation	Evidence	References	Source
located in axon	IDA IDA: Inferred from direct assay	12419325	RGD
located in cytosol	IDA IDA: Inferred from direct assay	18693253	RGD
located in nucleus	IDA IDA: Inferred from direct assay	18693253	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
myotrophin	V-1 protein granule cell differentiation protein growth factor protein V-1 stimulates myocyte growth

Mtpn Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Mtpn	P62775	Capzb	Rattus norvegicus	Q5XI32	Anti Bait CoIP	15845376

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08814	MTPN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Mtpn	NCBI	NCBI:136319