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MTPN - myotrophin Gene

Also Known as V-1; GCDP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 136319

About MTPN

Cytogenetic location: 7q33 Genomic coordinates (GRCh38): 7:135,926,760-135,977,359 (from NCBI)

This gene has 2 transcripts (splice variants), 194 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 74.6), esophagus (RPKM 68.4) and 24 other tissues.

Summary

The transcript produced from this gene is bi-cistronic and can encode both myotrophin and leucine zipper protein 6. The myotrophin protein is associated with cardiac hypertrophy, where it is involved in the conversion of NFkappa B p50-p65 heterodimers to p50-p50 and p65-p65 homodimers. This protein also has a potential function in cerebellar morphogenesis, and it may be involved in the differentiation of cerebellar neurons, particularly of granule cells. A cryptic ORF at the 3' end of this transcript uses a novel internal ribosome entry site and a non-AUG translation initiation codon to produce leucine zipper protein 6, a 6.4 kDa tumor antigen that is associated with myeloproliferative disease. [provided by RefSeq, Jul 2008]

MTPN Products (1)

mRNA	Protein	Name
NM_145808.4	NP_665807.1	myotrophin

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	10329199	GOA
involved in regulation of barbed-end actin filament capping	IDA IDA: Inferred from direct assay	16895918	GOA
involved in regulation of cell size	IDA IDA: Inferred from direct assay	10329199	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of F-actin capping protein complex	IDA IDA: Inferred from direct assay	16895918	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MTPN Protein Structure

Ank_2

0
100
118 a.a.

Protein Preferred Names	Protein Names
myotrophin	granule cell differentiation protein

Related Diseases

Diseases	Alias
Muscle Hypertrophy	MSLHP Hypertrophy Hypertrophy, Muscle
Lujo Hemorrhagic Fever	Zambian Hemorrhagic Fever
Dilated Cardiomyopathy	Familial Dilated Cardiomyopathy Primary Dilated Cardiomyopathy Idiopathic Dilated Cardiomyopathy Congestive Cardiomyopathy Idiopathic Dilation Cardiomyopathy Primary Familial Dilated Cardiomyopathy Cardiomyopathy, Dilated DCM Cardiomyopathy, Familial Dilated Dilated Cardiomyopathy, Familial Hypokinetic Dilated Cardiomyopathy, Familial Familial Idiopathic Cardiomyopathy Fdc Cardiomyopathy, Familial Idiopathic Idiopathic Cardiomegaly Dilated Congestive Cardiomyopathy Chronic Dilated Cardiomyopathy Ccm - [Congestive Cardiomyopathy] Cocm - [Congestive Cardiomyopathy] Dcm - [Dilated Cardiomyopathy] Dilated-Hypokinetic Cardiomyopathy Congestive Idiopathic Cardiomyopathy Primary Idiopathic Dilated Cardiomyopathy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08814	MTPN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MTPN	VGNC	VGNC:50020
Felis catus	MTPN	VGNC	VGNC:63658
Macaca mulatta	MTPN	VGNC	VGNC:74962
Rattus norvegicus	MTPN	RGD	RGD:619806
Canis familiaris	MTPN	VGNC	VGNC:51815
Mus musculus	MTPN	MGD	MGI:99445
Others	MTPN	NCBI