LRP12 - LDL receptor related protein 12 Gene

Also Known as ST7; MIG13A

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 29967

About LRP12

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:104,489,236-104,589,258 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 14 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 9.3), brain (RPKM 7.5) and 25 other tissues.

Summary

This gene encodes a member of the low-density lipoprotein receptor related protein family. The product of this gene is a transmembrane protein that is differentially expressed in many Cancer cells. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

LRP12 Products (2)

mRNA Protein Name
NM_001135703.3 NP_001129175.1 low-density lipoprotein receptor-related protein 12 isoform b precursor
NM_013437.5 NP_038465.1 low-density lipoprotein receptor-related protein 12 isoform a precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
12809483 GOA
Biological Process GO Annotation Evidence References Source
acts upstream of or within neuron migration IDA
IDA: Inferred from direct assay
26639854 GOA
acts upstream of or within neuron projection development IDA
IDA: Inferred from direct assay
26639854 GOA
Cellular Component GO Annotation Evidence References Source
located in plasma membrane IDA
IDA: Inferred from direct assay
12809483 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LRP12 Protein Structure

CUB

CUB: CUB domain (47 - 156)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (164 - 200)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (214 - 254)

CUB

CUB: CUB domain (259 - 369)

Ldl_recept_a

Ldl_recept_a: Low-density lipoprotein receptor domain class A (451 - 485)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 859 a.a.
Protein Preferred Names Protein Names

low-density lipoprotein receptor-related protein 12

  • LDLR-related protein 12

LRP12 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
LRP12 Q9Y561 RACK1 Homo sapiens P63244
Anti Tag CoIP
12809483
Intra
LRP12 Q9Y561 NMRK2 Homo sapiens Q9NPI5
Y2H
12809483
Intra
LRP12 Q9Y561 NMRK2 Homo sapiens Q9NPI5
Anti Tag CoIP
12809483
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant LRP12 Proteins

Cat. No. Product Name Accession Purity
HY-P70946 LRP-12 Protein, Human (HEK293, His) Q9Y561-1 (E33-I488) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Oculopharyngodistal Myopathy 1

  • Oculopharyngodistal Myopathy

  • Opdm

  • OPDM1

  • Faciooculolaryngopharyngeal Myopathy With Distal And Respiratory Involvement

  • Folp-Dr

  • Oculopharyngeal Distal Myopathy

  • Myopathy, Oculopharyngodistal

  • Myopathy, Oculopharyngodistal, Type 1
Neuronal Intranuclear Inclusion Disease

  • NIID

  • Neuronal Intranuclear Hyaline Inclusion Disease
Retinitis Pigmentosa 62

  • RP62

  • Retinitis Pigmentosa, Type 62
Ptosis

  • Blepharoptosis

  • Drooping Eyelid

  • Droopy Eyelid

  • Ptosis Of Eyelid

  • Paralysis Of Levator Palpebrae Superioris
Fatal Infantile Hypertonic Myofibrillar Myopathy
Myopathy

  • Muscular Diseases

  • Myopathies
Epilepsy, Familial Adult Myoclonic, 3

  • FAME3

  • Fcmte3

  • Cortical Myoclonic Tremor With Epilepsy, Familial, 3

  • Familial Adult Myoclonic Epilepsy 3

  • Familial Cortical Myoclonic Tremor And Epilepsy 3

  • Epilepsy, Myoclonic, Familial Adult, Type 3
Familial Adult Myoclonic Epilepsy

  • Benign Adult Familial Myoclonus Epilepsy

  • Bafme

  • Benign Adult Familial Myoclonic Epilepsy

  • Fame

  • Familial Cortical Myoclonic Tremor And Epilepsy

  • Fcmte

  • Adcme

  • Autosomal Dominant Cortical Myoclonus And Epilepsy

  • Fam

  • Epilepsy, Myoclonic, Familial Adult

  • Epilepsy, Myoclonic, Benign Adult Familial, Type 2
Oculopharyngeal Muscular Dystrophy

  • OPMD

  • Muscular Dystrophy, Oculopharyngeal

  • Dystrophy, Oculopharyngeal Muscular

  • Oculopharyngeal Dystrophy

  • Progressive Muscular Dystrophy, Oculopharyngeal Type

  • Muscular Dystrophy Oculopharyngeal

  • Dystrophy, Muscular, Oculopharyngeal
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07795 LRP12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19708 Lrp12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26204 Lrp12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LRP12 VGNC VGNC:59046
Mus musculus LRP12 MGD MGI:2443132
Rattus norvegicus LRP12 RGD RGD:1304943
Macaca mulatta LRP12 VGNC VGNC:74410
Bos taurus LRP12 VGNC VGNC:30989
Others LRP12 NCBI