LRP-12 Protein, Human (HEK293, His)

LRP-12, a probable receptor, potentially facilitates the internalization of lipophilic molecules and signal transduction. It may function as a tumor suppressor and interacts with proteins RACK1, ZFYVE9, and NMRK2. LRP-12 Protein, Human (HEK293, His) is the recombinant human-derived LRP-12 protein, expressed by HEK293 , with C-6*His labeled tag.

LRP-12 Protein emerges as a probable receptor with potential roles in the internalization of lipophilic molecules and/or signal transduction, implicating its significance in cellular processes. Additionally, it is suggested to function as a tumor suppressor, underscoring its potential involvement in regulating cell growth and preventing tumorigenesis. LRP-12 also exhibits interactions with key proteins, including RACK1, ZFYVE9, and NMRK2, indicating a network of associations that may contribute to its diverse cellular functions. The complex interplay of LRP-12 with various molecules suggests a multifunctional role, emphasizing its importance in cellular homeostasis and potential implications in disease pathways.

Measured by its binding ability in a functional ELISA.When Recombinant Human LRP-12 is immobilized at 0.5 μg/mL, 100 μL/well can bind Recombinant Human LRPAP (HY-P76478). The ED₅₀ for this effect is 1.763 μg/mL.

Human

HEK293

C-6*His

Q9Y561-1 (E33-I488)

29967  [NCBI]

Extracellular Domain

EHSENVHISGVSTACGETPEQIRAPSGIITSPGWPSEYPAKINCSWFIRANPGEIITISFQDFDIQGSRRCNLDWLTIETYKNIESYRACGSTIPPPYISSQDHIWIRFHSDDNISRKGFRLAYFSGKSEEPNCACDQFRCGNGKCIPEAWKCNNMDECGDSSDEEICAKEANPPTAAAFQPCAYNQFQCLSRFTKVYTCLPESLKCDGNIDCLDLGDEIDCDVPTCGQWLKYFYGTFNSPNYPDFYPPGSNCTWLIDTGDHRKVILRFTDFKLDGTGYGDYVKIYDGLEENPHKLLRVLTAFDSHAPLTVVSSSGQIRVHFCADKVNAARGFNATYQVDGFCLPWEIPCGGNWGCYTEQQRCDGYWHCPNGRDETNCTMCQKEEFPCSRNGVCYPRSDRCNYQNHCPNGSDEKNCFFCQPGNFHCKNNRCVFESWVCDSQDDCGDGSDEENCPVI

Approximately 60-85 kDa due to the glycosylation.

• 
  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

1.Lyophilized from a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
2.Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4, 8% trehalose.
Please refer to the lot-specific COA for specific buffer information.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.