SERPIND1 - serpin family D member 1 Gene

Homo sapiens

Also known as HC2; LS2; HCF2; HCII; HLS2; THPH10; D22S673

Gene ID: 3053 | Gene type: protein coding

About SERPIND1

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:20,774,113-20,787,720 (from NCBI)

This gene has 2 transcripts (splice variants), 199 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward liver (RPKM 330.2).

Summary

This gene belongs to the serpin gene superfamily. Serpins play roles in many processes including inflammation, blood clotting, and Cancer metastasis. Members of this family have highly conserved secondary structures with a reactive center loop that interacts with the protease active site to inhibit protease activity. This gene encodes a plasma serine protease that functions as a Thrombin and chymotrypsin inhibitor. The protein is activated by heparin, dermatan sulfate, and glycosaminoglycans. Allelic variations in this gene are associated with Heparin Cofactor II deficiency. [provided by RefSeq, Jul 2015]

SERPIND1 Products(1)

mRNA	Protein	Name
NM_000185.4	NP_000176.2	heparin cofactor 2 precursor

SERPIND1 Protein Structure

Serpin

0
100
200
300
400
499 a.a.

Protein Preferred Names

Protein Names

heparin cofactor 2

leuserpin 2

Recombinant SERPIND1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77199	Serpin D1 Protein, Human (HEK293, His)	P05546 (G20-S499)	≥95%

Related Diseases

Diseases

Alias

Heparin Cofactor Ii Deficiency

Thrombophilia Due To Heparin Cofactor Ii Deficiency	THPH10
Hcf Ii Deficiency	Hcf2 Deficiency
Thrombophilia 10 Due To Heparin Cofactor Ii Deficiency	Hcf 2 Deficiency
Thrombophilia Due To Heparin Cofactor 2 Deficiency	Thrombophilia, Due To Heparin Cofactor Ii Deficiency

Thrombophilia

Hypercoagulability State

Dysfibrinogenemia, Congenital

Dysfibrinogenemia	Hypodysfibrinogenemia
Familial Dysfibrinogenemia	Familial Hypodysfibrinogenemia
Hypodysfibrinogenemia, Congenital	Dysfibrinogenemia, Familial
Congenital Dysfibrinogenemia	DYSFIBRIN

Uterus Carcinoma In Situ

Thrombosis

Thrombosis Of Blood Vessel

Cervix Uteri Carcinoma In Situ

Carcinoma In Situ Of Cervix	Carcinoma In Situ Of Uterine Cervix
Cervical Intraepithelial Neoplasia	Carcinoma Of Cervix Stage 0
Cervical Intraepithelial Neoplasia Grade Iii With Severe Dysplasia	Cervix Ca In Situ
Cin Iii	Cin Iii - Carcinoma In Situ Of Cervix
Cin Iii - Severe Dyskaryosis	Severe Dysplasia Of Cervix
Severe Dysplasia Of The Cervix Uteri	Squamous Intraepithelial Neoplasia, Grade Iii
Cervix Intraepithelial Neoplasia Grade 3 Ajcc V7

Chronic Cervicitis

Prothrombin Thrombophilia

Prothrombin G20210a Thrombophilia

Hyperprothrombinemia

Stroke, Ischemic

Cerebral Infarction	Stroke
Ischemic Stroke	Cerebrovascular Accident
Cerebral Infarction, Susceptibility To	Stroke, Ischemic, Susceptibility To
Cerebral Infarct	Ischemic Stroke, Susceptibility To
Stroke, Susceptibility To	Cva - Cerebral Infarction
ISCHSTR	Ischemic Cerebrovascular Accident

Hurler-Scheie Syndrome

Mucopolysaccharidosis Type Ih/S	Mucopolysaccharidosis Ih/S
MPS1H/S	Mpsih/S
Mucopolysaccharidosis Type 1h/S	Mps1-Hs
Alpha-L-Iduronidase Deficiency	Mucopolysaccharidosis I
Mucopolysaccharidosis 1h/S	Mps-Ih/S

Waardenburg Syndrome, Type 3

Waardenburg Syndrome Type 3	Klein-Waardenburg Syndrome
WS3	Waardenburg Syndrome With Upper Limb Anomalies
Waardenburg Syndrome Type Iii	Waardenburg Syndrome, Type Iii
White Forelock Syndrome With Multiple Congenital Malformations	Waardenburg Syndrome With Limb Anomalies
Waardenburg Syndrome 3	White Forelock With Malformations
Klein'S Syndrome

Cervicitis

Uterine Cervicitis

Inflammation Of Cervix

Encephalopathy, Familial, With Neuroserpin Inclusion Bodies

Familial Encephalopathy With Neuroserpin Inclusion Bodies	FENIB
Encephalopathy, Familial, With Collins Bodies	Familial Dementia With Neuroserpin Inclusion Bodies
Familial Encephalopathy With Collins Bodies

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12719	SERPIND1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	SERPIND1	VGNC	VGNC:34475
Rattus norvegicus	SERPIND1	RGD	RGD:619854
Macaca mulatta	SERPIND1	VGNC	VGNC:77357
Canis familiaris	SERPIND1	VGNC	VGNC:46035
Mus musculus	SERPIND1	MGD	MGI:96051
Felis catus	SERPIND1	VGNC	VGNC:67540

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