Fbxw5 - F-box and WD-40 domain protein 5 Gene

Also Known as Fbw5

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30839

Summary

Predicted to enable protein kinase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of mitotic nuclear division. Part of SCF ubiquitin Ligase complex. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human FBXW5 (F-box and WD repeat domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Fbxw5 Products (3)

mRNA Protein Name
NM_001356407.1 NP_001343336.1 F-box/WD repeat-containing protein 5 isoform 2
NM_001356408.1 NP_001343337.1 F-box/WD repeat-containing protein 5 isoform 3
NM_013908.5 NP_038936.1 F-box/WD repeat-containing protein 5 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21600655 MGI
Biological Process GO Annotation Evidence References Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IDA
IDA: Inferred from direct assay
23314863 MGI
involved in protein ubiquitination IDA
IDA: Inferred from direct assay
23314863 MGI
involved in regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
23314863 MGI
Cellular Component GO Annotation Evidence References Source
part of SCF ubiquitin ligase complex IDA
IDA: Inferred from direct assay
23314863 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

F-box/WD repeat-containing protein 5

  • F-box and WD-40 domain-containing protein 5

  • F-box protein Fbw5

Fbxw5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Fbxw5 Q9QXW2 Skp1 Mus musculus Q9WTX5
Pull Down
23314863
Intra
Fbxw5 Q9QXW2 Skp1 Mus musculus Q9WTX5
GMS
23314863
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS04817 FBXW5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Fbxw5 NCBI NCBI:54461