Fbxw5 - F-box and WD-40 domain protein 5 Gene

Mus musculus

Also known as Fbw5

Gene ID: 30839 | Gene type: protein coding

About Fbxw5

Summary

Predicted to enable protein kinase binding activity. Involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process; protein ubiquitination; and regulation of mitotic nuclear division. Part of SCF ubiquitin Ligase complex. Is expressed in central nervous system; embryo; retina inner nuclear layer; and retina outer nuclear layer. Orthologous to human FBXW5 (F-box and WD repeat domain containing 5). [provided by Alliance of Genome Resources, Apr 2022]

Fbxw5 Products(3)

mRNA	Protein	Name
NM_001356407.1	NP_001343336.1	F-box/WD repeat-containing protein 5 isoform 2
NM_001356408.1	NP_001343337.1	F-box/WD repeat-containing protein 5 isoform 3
NM_013908.5	NP_038936.1	F-box/WD repeat-containing protein 5 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	21600655	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	23314863	MGI
involved in protein ubiquitination	IDA IDA: Inferred from direct assay	23314863	MGI
involved in regulation of mitotic nuclear division	IDA IDA: Inferred from direct assay	23314863	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of SCF ubiquitin ligase complex	IDA IDA: Inferred from direct assay	23314863	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

F-box/WD repeat-containing protein 5

F-box and WD-40 domain-containing protein 5

F-box protein Fbw5

Fbxw5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Fbxw5	Q9QXW2	Skp1	Mus musculus	Q9WTX5	Pull Down	23314863
Intra	Fbxw5	Q9QXW2	Skp1	Mus musculus	Q9WTX5	GMS	23314863

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04817	FBXW5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fbxw5	NCBI	NCBI:54461

Name
Email *

	Sorry, but the email address you supplied was invalid.