Angptl3 - angiopoietin-like 3 Gene

Also Known as hypl

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30924

Summary

This gene encodes a member of the angiopoietin-like family of proteins. The encoded preproprotein is proteolytically processed to generate multiple protein products, which may inhibit triglyceride metabolism. Homozygous knockout mice for this gene exhibit reduced plasma lipid concentrations, including reduced plasma triglyceride concentrations, and enhanced activity of Enzymes involved in triglyceride metabolism. [provided by RefSeq, Aug 2015]

Angptl3 Products (1)

mRNA Protein Name
NM_013913.4 NP_038941.1 angiopoietin-related protein 3 preproprotein

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables enzyme inhibitor activity IDA
IDA: Inferred from direct assay
12097324 MGI
Biological Process GO Annotation Evidence References Source
involved in acylglycerol homeostasis IMP
IMP: Inferred from mutant phenotype
17110602 MGI
involved in artery morphogenesis IMP
IMP: Inferred from mutant phenotype
12671033 MGI
involved in cholesterol homeostasis IMP
IMP: Inferred from mutant phenotype
17110602 MGI
involved in negative regulation of phospholipase activity IMP
IMP: Inferred from mutant phenotype
17110602 MGI
involved in phospholipid homeostasis IMP
IMP: Inferred from mutant phenotype
17110602 MGI
involved in triglyceride homeostasis IMP
IMP: Inferred from mutant phenotype
19542565 MGI
Cellular Component GO Annotation Evidence References Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
23918928 MGI
located in cell surface IDA
IDA: Inferred from direct assay
23918928 MGI
located in early endosome IDA
IDA: Inferred from direct assay
23918928 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

angiopoietin-related protein 3

  • angiopoietin-like protein 3

Recombinant Angptl3 Proteins

Cat. No. Product Name Accession Purity
HY-P7504 ANGPTL3/Angiopoietin-like 3 Protein, Mouse (HEK293, His) Q9R182 (S17-T206) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-153497A Vupanorsen sodium Inhibitor 98.33% Phase 2
HY-153497 Vupanorsen Inhibitor 92.29% Phase 2

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-185318A Lexosiran sodium Inhibitor / Unkown
HY-185318 Lexosiran Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Angptl3 NCBI NCBI:27329