ANGPTL3 - angiopoietin like 3 Gene

Also Known as ANL3; ANG-5; FHBL2; ANGPT5

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27329

About ANGPTL3

Cytogenetic location: 1p31.3 Genomic coordinates (GRCh38): 1:62,597,520-62,606,313 (from NCBI)

This gene has 3 transcripts (splice variants), 257 orthologues, 25 paralogues and is associated with 2 phenotypes. Restricted expression toward liver (RPKM 171.2).

Summary

This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015]

ANGPTL3 Products (1)

mRNA	Protein	Name
NM_014495.4	NP_055310.1	angiopoietin-related protein 3 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables growth factor activity	IDA IDA: Inferred from direct assay	11877390	GOA
enables integrin binding	IPI IPI: Inferred from physical interaction	11877390	GOA
enables phospholipase inhibitor activity	IDA IDA: Inferred from direct assay	17110602	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in acylglycerol homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in cell-matrix adhesion	IPI IPI: Inferred from physical interaction	11877390	GOA
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in cholesterol metabolic process	IDA IDA: Inferred from direct assay	17110602	GOA
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	12565906	GOA
involved in glycerol metabolic process	IDA IDA: Inferred from direct assay	12565906	GOA
involved in lipid homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in lipid storage	IDA IDA: Inferred from direct assay	12565906	GOA
involved in negative regulation of lipoprotein lipase activity	IDA IDA: Inferred from direct assay	17110602	GOA
involved in negative regulation of phospholipase activity	IDA IDA: Inferred from direct assay	17110602	GOA
involved in phospholipid catabolic process	IDA IDA: Inferred from direct assay	17110602	GOA
involved in phospholipid homeostasis	IDA IDA: Inferred from direct assay	17110602	GOA
involved in phospholipid metabolic process	IDA IDA: Inferred from direct assay	17110602	GOA
involved in positive regulation of angiogenesis	IDA IDA: Inferred from direct assay	11877390	GOA
involved in positive regulation of cell migration	IDA IDA: Inferred from direct assay	11877390	GOA
involved in positive regulation of lipid catabolic process	IDA IDA: Inferred from direct assay	12565906	GOA
involved in signal transduction	IDA IDA: Inferred from direct assay	11877390	GOA
acts upstream of or within triglyceride homeostasis	IGI IGI: Inferred from genetic interaction	23150577	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	12565906	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	17110602	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ANGPTL3 Protein Structure

Fibrinogen_C

0
100
200
300
400
460 a.a.

Protein Preferred Names	Protein Names
angiopoietin-related protein 3	angiopoietin 5

Recombinant ANGPTL3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7505	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His)	Q9Y5C1 (S17-P220)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P75580	ANGPTL3/Angiopoietin-like 3 Protein, Human (sf9, His)	Q9Y5C1 (S17-E460)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P78059	ANGPTL3/Angiopoietin-like 3 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9Y5C1 (S17-K219)	≥ 95%, as determined by Bis-Tris PAGE.
HY-P78379	ANGPTL3/Angiopoietin-like 3 Protein, Human (HEK293, His-Avi)	Q9Y5C1 (S17-K219)	≥ 95%, as determined by Bis-Tris PAGE.

ANGPTL3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82271	ANGPTL3 Antibody (YA2016)	WB, ICC/IF	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Hypobetalipoproteinemia, Familial, 2	Familial Hypobetalipoproteinemia 2 FHBL2 Hypolipidemia, Familial, Combined Combined Familial Hypolipidemia Combined Hypobetalipoproteinemia Familial Hypobetalipoproteinemia, Familial, Type 2
Hypobetalipoproteinemia, Familial, 1	Hypobetalipoproteinemia Familial Hypobetalipoproteinemia 1 Familial Hypobetalipoproteinemia FHBL1 Hypobetalipoproteinemia, Familial Fhbl Acanthocytosis With Hypobetalipoproteinemia Hypobetalipoproteinemias Hypobetalipoproteinemia, Normotriglyceridemic Hypo-Beta-Lipoproteinemia Hypobetalipoprotéinemia, Familial Normotriglyceridemic Hypobetalipoproteinemia Hypobetalipoproteinemia, Familial, Type 1
Nephrotic Syndrome	Finnish Congenital Nephrotic Syndrome Ns - [Nephrotic Syndrome] Nephrosis Syndrome Nephrosis Nos Glomerular Lesion Nephrosis
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Hyperlipoproteinemia, Type I	Lipoprotein Lipase Deficiency Familial Chylomicronemia Syndrome Lpl Deficiency Hyperchylomicronemia, Familial Hyperlipemia, Idiopathic, Burger-Grutz Type Hyperlipemia, Essential Familial Lipase D Deficiency Lipd Deficiency Hyperlipoproteinemia, Type Ia Chylomicronemia, Familial High Density Lipoprotein Cholesterol Level Qtl 11 Hyperlipoproteinemia Type 1 Hyperlipoproteinemia 1 HLPP1 Lipoprotein Lipase Hyperlipoproteinemia Type I Familial Hyperchylomicronemia Syndrome
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Hyperlipoproteinemia, Type Iv	Hyperlipoproteinemia Type Iv Carbohydrate-Inducible Hyperlipemia Endogenous Hyperlipidaemia Familial Hypertriglyceridemia Fredrickson Type Iv Hyperlipoproteinemia Fredrickson Type Iv Lipidaemia Fredrickson Type Iv Lipidemia Vldl Hyperlipoproteinemia Hyperlipoproteinemia Type 4 Carbohydrate Inducible Hyperlipemia Familial Type Iv Hyperlipoproteinemia Familial Hyperlipoproteinemia Type Iv
Familial Lipoprotein Lipase Deficiency	Familial Lpl Deficiency Familial Hyperchylomicronemia Hyperlipoproteinemia Type I Familial Hyperlipoproteinemia Type I Hyperchylomicronemia Burger-Grutz Syndrome Endogenous Hypertriglyceridaemia Familial Fat-Induced Hypertriglyceridemia Lipd Deficiency Lpl Deficiency Lipase D Deficiency Lipoprotein Lipase Deficiency, Familial Familial Chylomicronemia Syndrome Fredrickson Type I Hyperlipoproteinemia Fredrickson Type I Lipaemia Hypercholesterinaemic Xanthomatosis Mixed Hyperglyceridemia Lipoprotein Lipase Deficiency Type I Hyperlipoproteinemia Hyperlipoproteinemia Type Ia Familial Hyperlipo-Proteinemia Type 1
Familial Apolipoprotein C-Ii Deficiency	Familial Apoc-Ii Deficiency Familial Apoc2 Deficiency C-Ii Anapolipoproteinemia Hyperlipoproteinemia, Type 1b Hyperlipoproteinemia, Type Ib Hyperlipoproteinemia Type I
Hyperlipoproteinemia, Type V	Hyperlipoproteinemia Type V Hyperchylomicronemia, Late-Onset Familial Type 5 Hyperlipoproteinemia Hyperchylomicronemia With Hyperprebetalipoproteinemia, Familial Hyperlipidemia, Type V Hyperlipemia, Mixed Hyperlipemia, Combined Fat And Carbohydrate-Induced Familial Hyperlipoproteinemia Type V Fredrickson Type V Lipaemia Hyperlipoproteinemia Type 5 Hyperchylomicronemia Late Onset Hyperlipemia Combined Fat And Carbohydrate-Induced Hyperlipemia Mixed Hyperlipidemia Type V Mixed Hyperlipemia Type V Hyperlipoproteinemia Hyperlipoproteinemia 5 HLPP5 Hyperlipidemia, Familial Combined Mixed Hyperlipidemia
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Familial Hypercholesterolemia	Hyperlipoproteinemia Type Iia Familial Hyperbetalipoproteinaemia Familial Hypercholesteremia Fredrickson Type Iia Hyperlipoproteinemia Fredrickson Type Iia Lipidaemia Hyperbetalipoproteinemia Type Ii Hyperlipidemia Familial Hypercholesterolæmia Familial Hypercholesterolaemia Fh Hypercholesterolemia Familial Hyperlipoproteinemia Type Ii Hypercholesterolemia, Familial
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Diabetes Mellitus	Diabetes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Phase
HY-153497A	Vupanorsen sodium	Inhibitor	98.33%	Phase 2
HY-153497	Vupanorsen	Inhibitor	92.29%	Phase 2

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-185318A	Lexosiran sodium	Inhibitor	/	Unkown
HY-185318	Lexosiran	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ANGPTL3	VGNC	VGNC:99843
Canis familiaris	ANGPTL3	VGNC	VGNC:37859
Felis catus	ANGPTL3	VGNC	VGNC:67571
Bos taurus	ANGPTL3	VGNC	VGNC:25892
Rattus norvegicus	ANGPTL3	RGD	RGD:1564505
Mus musculus	ANGPTL3	MGD	MGI:1353627
Others	ANGPTL3	NCBI