Glrx3 - glutaredoxin 3 Gene

Also Known as PICOT; Txnl2

Species: Mus musculus

Gene Type: protein coding
Gene ID: 30926

Summary

Predicted to enable identical protein binding activity and protein kinase C binding activity. Involved in negative regulation of cardiac muscle hypertrophy and regulation of the force of heart contraction. Located in Z disc. Is expressed in several structures, including brain; egg cylinder; genitourinary system; gut; and white fat. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Apr 2022]

Glrx3 Products (2)

mRNA Protein Name
NM_001348093.1 NP_001335022.1 glutaredoxin-3 isoform 2
NM_023140.5 NP_075629.2 glutaredoxin-3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
18258855 MGI
Biological Process GO Annotation Evidence References Source
involved in negative regulation of cardiac muscle hypertrophy IMP
IMP: Inferred from mutant phenotype
18258855 MGI
involved in regulation of the force of heart contraction IMP
IMP: Inferred from mutant phenotype
18258855 MGI
Cellular Component GO Annotation Evidence References Source
located in Z disc IDA
IDA: Inferred from direct assay
18258855 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

glutaredoxin-3

  • PKC-interacting cousin of thioredoxin

  • PKC-theta-interacting protein

  • PKCq-interacting protein

  • thioredoxin-like protein 2

Glrx3 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
Glrx3 Q9CQM9 Ciapin1 Mus musculus Q8WTY4
Y2H
21513700
Intra
Glrx3 Q9CQM9 Ciapin1 Mus musculus Q8WTY4
Anti Tag CoIP
21513700
Intra
Glrx3 Q9CQM9 Ciapin1 Mus musculus Q8WTY4
Pull Down
21513700
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS05498 GLRX3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Glrx3 NCBI NCBI:10539