Glrx3 - glutaredoxin 3 Gene

Mus musculus

Also known as PICOT; Txnl2

Gene ID: 30926 | Gene type: protein coding

About Glrx3

Summary

Predicted to enable identical protein binding activity and protein kinase C binding activity. Involved in negative regulation of cardiac muscle hypertrophy and regulation of the force of heart contraction. Located in Z disc. Is expressed in several structures, including brain; egg cylinder; genitourinary system; gut; and white fat. Orthologous to human GLRX3 (glutaredoxin 3). [provided by Alliance of Genome Resources, Apr 2022]

Glrx3 Products(2)

mRNA	Protein	Name
NM_001348093.1	NP_001335022.1	glutaredoxin-3 isoform 2
NM_023140.5	NP_075629.2	glutaredoxin-3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18258855	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: Inferred from mutant phenotype	18258855	MGI
involved in regulation of the force of heart contraction	IMP IMP: Inferred from mutant phenotype	18258855	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	18258855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

glutaredoxin-3

PKC-interacting cousin of thioredoxin	PKC-theta-interacting protein
PKCq-interacting protein	thioredoxin-like protein 2

Glrx3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	Glrx3	Q9CQM9	Ciapin1	Mus musculus	Q8WTY4	Y2H	21513700
Intra	Glrx3	Q9CQM9	Ciapin1	Mus musculus	Q8WTY4	Anti Tag CoIP	21513700
Intra	Glrx3	Q9CQM9	Ciapin1	Mus musculus	Q8WTY4	Pull Down	21513700

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05498	GLRX3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Glrx3	NCBI	NCBI:10539

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