AOC2 - amine oxidase copper containing 2 Gene

Also Known as RAO; DAO2; SSAO

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 314

About AOC2

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:42,844,580-42,850,707 (from NCBI)

This gene has 2 transcripts (splice variants), 266 orthologues and 2 paralogues. Broad expression in fat (RPKM 4.0), testis (RPKM 2.5) and 14 other tissues.

Summary

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

AOC2 Products (2)

mRNA Protein Name
NM_001158.5 NP_001149.2 retina-specific copper amine oxidase isoform a precursor
NM_009590.4 NP_033720.2 retina-specific copper amine oxidase isoform b precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables primary methylamine oxidase activity IDA
IDA: Inferred from direct assay
19588076 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
19588076 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
19588076 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AOC2 Protein Structure

Cu_amine_oxidN2

Cu_amine_oxidN2: Copper amine oxidase, N2 domain (62 - 148)

Cu_amine_oxidN3

Cu_amine_oxidN3: Copper amine oxidase, N3 domain (165 - 262)

Cu_amine_oxid

Cu_amine_oxid: Copper amine oxidase, enzyme domain (307 - 718)

  • 0
  • 200
  • 400
  • 600
  • 756 a.a.
Protein Preferred Names Protein Names

retina-specific copper amine oxidase

  • amine oxidase, copper containing 2 (retina-specific)

AOC2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
AOC2 O75106 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
AOC2 O75106 AQP6 Homo sapiens Q13520
Validated Y2H
32296183
Intra
AOC2 O75106 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
AOC2 O75106 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
AOC2 O75106 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
AOC2 O75106 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant AOC2 Proteins

Cat. No. Product Name Accession Purity
HY-P78881 Fc gamma RIIIB/CD16b Protein, Human (Biotinylated, NA1, HEK293, His-Avi) AAA35881.1 (G17-S200) ≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Median Neuropathy
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Retinitis Pigmentosa

  • RP

  • Rod-Cone Dystrophy

  • Autosomal Recessive Retinitis Pigmentosa

  • Non-Syndromic Retinitis Pigmentosa

  • Pericentral Pigmentary Retinopathy

  • Pigmentary Retinopathy

  • Tapetoretinal Degeneration

  • Rcd

  • Retinitis Pigmentosa Autosomal Recessive

  • ARRP

  • Retinitis Pigmentosa, Autosomal Recessive

  • Retinitis Pigmentosa 1
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-143721 SSAO inhibitor-2 Inhibitor / Unkown
HY-RS00772 AOC2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AOC2 RGD RGD:727941
Mus musculus AOC2 MGD MGI:2668431
Macaca mulatta AOC2 VGNC VGNC:69955
Canis familiaris AOC2 VGNC VGNC:37948
Bos taurus AOC2 VGNC VGNC:25973