AOC2 - amine oxidase copper containing 2 Gene

Homo sapiens

Also known as RAO; DAO2; SSAO

Gene ID: 314 | Gene type: protein coding

About AOC2

Cytogenetic location: 17q21.31 Genomic coordinates (GRCh38): 17:42,844,580-42,850,707 (from NCBI)

This gene has 2 transcripts (splice variants), 266 orthologues and 2 paralogues. Broad expression in fat (RPKM 4.0), testis (RPKM 2.5) and 14 other tissues.

Summary

Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]

AOC2 Products(2)

mRNA	Protein	Name
NM_001158.5	NP_001149.2	retina-specific copper amine oxidase isoform a precursor
NM_009590.4	NP_033720.2	retina-specific copper amine oxidase isoform b precursor

AOC2 Protein Structure

Cu_amine_oxidN2

Cu_amine_oxidN3

Cu_amine_oxid

0
200
400
600
756 a.a.

Protein Preferred Names

Protein Names

retina-specific copper amine oxidase

amine oxidase, copper containing 2 (retina-specific)

Recombinant AOC2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P78881	Fc gamma RIIIB/CD16b (NA1) Protein, Human (Biotinylated, HEK293, His-Avi)	AAA35881.1 (G17-S200)	≥95%

Related Diseases

Diseases

Alias

Median Neuropathy

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis	ALS
Lou Gehrig Disease	Amyotrophic Lateral Sclerosis Type 1
Charcot Disease	ALS1
Amyotrophic Lateral Sclerosis, Susceptibility To	Fals
Lou Gehrig'S Disease	Mnd
Motor Neuron Disease	Familial Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 1, Familial	Amyotrophic Lateral Sclerosis 1, Autosomal Dominant
Motor Neuron Disease, Bulbar	Motor Neurone Disease
Amyotrophic Lateral Sclerosis With Dementia	Dementia With Amyotrophic Lateral Sclerosis
Motor Neuron Disease, Amyotrophic Lateral Sclerosis	Sclerosis, Lateral, Amyotrophic
Sclerosis, Lateral, Amyotrophic, Type 1	Amyotrophic Sclerosis
Als - [Amyotrophic Lateral Sclerosis]	Wasting Palsy
Amyotrophic Paralysis	Amyotrophy Lateral Sclerosis
Wasting Paralysis	Spinal Progressive Amyotrophy
Progressive Atrophic Paralysis

Retinitis Pigmentosa

RP	Rod-Cone Dystrophy
Autosomal Recessive Retinitis Pigmentosa	Non-Syndromic Retinitis Pigmentosa
Pericentral Pigmentary Retinopathy	Pigmentary Retinopathy
Tapetoretinal Degeneration	Rcd
Retinitis Pigmentosa Autosomal Recessive	ARRP
Retinitis Pigmentosa, Autosomal Recessive	Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00772	AOC2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	AOC2	RGD	RGD:727941
Mus musculus	AOC2	MGD	MGI:2668431
Macaca mulatta	AOC2	VGNC	VGNC:69955
Canis familiaris	AOC2	VGNC	VGNC:37948
Bos taurus	AOC2	VGNC	VGNC:25973