HOXB1 - homeobox B1 Gene

Homo sapiens

Also known as HOX2; HCFP3; HOX2I; Hox-2.9

Gene ID: 3211 | Gene type: protein coding

About HOXB1

Cytogenetic location: 17q21.32 Genomic coordinates (GRCh38): 17:48,528,526-48,531,011 (from NCBI)

This gene has 2 transcripts (splice variants), 187 orthologues, 42 paralogues and is associated with 3 phenotypes. Low expression observed in reference dataset.

Summary

This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXB genes located in a cluster on chromosome 17. [provided by RefSeq, Jul 2008]

HOXB1 Products(1)

mRNA	Protein	Name
NM_002144.4	NP_002135.2	homeobox protein Hox-B1

HOXB1 Protein Structure

Homeobox

0
100
200
301 a.a.

Protein Preferred Names

Protein Names

homeobox protein Hox-B1

homeobox protein Hox-2I

Related Diseases

Diseases

Alias

Facial Paresis, Hereditary Congenital, 3

HCFP3

Congenital Hereditary Facial Paralysis-Variable Hearing Loss Syndrome

Congenital Hereditary Facial Palsy With Variable Deafness	Congenital Hereditary Facial Palsy With Variable Hearing Loss
Congenital Hereditary Facial Paralysis With Variable Deafness	Congenital Hereditary Facial Paralysis-Variable Deafness Syndrome

Athabaskan Brainstem Dysgenesis Syndrome

Bosley-Salih-Alorainy Syndrome	Navajo Brainstem Syndrome
ABDS	Human Hoxa1 Syndromes
BSAS	Athabaskan Brainstem Dysgenesis
Bosley Salih Alorainy Syndrome	Absd
Athabascan Brainstem Dysgenesis Syndrome	Narvajo Brainstem Syndrome

Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias

Guttmacher Syndrome	Preaxial Deficiency, Postaxial Polydactyly And Hypospadias
Autosomal Dominant Preaxial Deficiency, Postaxial Polydactyly, And Hypospadias	Preaxial Deficiency-Postaxial Polydactyly-Hypospadias Syndrome
GUTTS

Facial Nerve Disease

Facial Nerve Disorder	Facial Nerve Diseases
Neuropathy Of Facial Nerve	Disorders Of 7th Cranial Nerve
Disorders Of The Seventh Cranial Nerve

Strabismus

Strabismus, Susceptibility To	Strabismus, Susceptibility To, 1
Strabismus 1

Facial Paralysis

Facial Palsy

Bell Palsy

Bell'S Palsy

Bell Palsy	Facial Nerve Palsy
Facial Palsy	Facial Paralysis
Bell'S Palsy	Antoni'S Palsy
Facial Cranial Nerve Paralysis	Idiopathic Facial Palsy
Refrigeration Palsy	Facial Nerve Paralysis
Seventh Cranial Nerve Paralysis	Face Paralysis Nos

Hand-Foot-Genital Syndrome

Hand-Foot-Uterus Syndrome	Hfgs
Hfg Syndrome	Hfu Syndrome
HFG	Hfu
Hand Foot Uterus Syndrome	Hand Foot Genital Syndrome

Congenital Fibrosis Of The Extraocular Muscles

Congenital Fibrosis Of Extraocular Muscles	Cfeom
Feom	Congenital External Ophthalmoplegia
Congenital Fibrosis Syndrome	General Fibrosis Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06304	HOXB1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	HOXB1	MGD	MGI:96182
Felis catus	HOXB1	VGNC	VGNC:67621
Macaca mulatta	HOXB1	VGNC	VGNC:73504
Rattus norvegicus	HOXB1	RGD	RGD:1310298
Canis familiaris	HOXB1	VGNC	VGNC:41749
Bos taurus	HOXB1	VGNC	VGNC:29916

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