Pkd2l1 - polycystic kidney disease 2-like 1 Gene

Also Known as PCL; Pkdl; PKD2L; TRPP3; B830002B15

Species: Mus musculus

Gene Type: protein coding

Gene ID: 329064

Summary

Enables Calcium Channel activity; calcium ion binding activity; and identical protein binding activity. Contributes to cation transmembrane transporter activity and sour Taste Receptor activity. Involved in several processes, including cellular response to acidic pH; detection of chemical stimulus involved in sensory perception of sour taste; and protein tetramerization. Located in endoplasmic reticulum and plasma membrane. Is integral component of plasma membrane. Part of Calcium Channel complex and receptor complex. Colocalizes with cell surface. Is expressed in cochlea; medulla oblongata; spinal cord; and tongue. Orthologous to human PKD2L1 (polycystin 2 like 1, transient receptor potential cation channel). [provided by Alliance of Genome Resources, Apr 2022]

Pkd2l1 Products (1)

mRNA	Protein	Name
NM_181422.3	NP_852087.2	polycystic kidney disease 2-like 1 protein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables calcium channel activity	IMP IMP: Inferred from mutant phenotype	24336288	MGI
enables calcium ion binding	IDA IDA: Inferred from direct assay	20408813	MGI
enables identical protein binding	IPI IPI: Inferred from physical interaction	16891422	MGI
contributes to monoatomic cation channel activity	IDA IDA: Inferred from direct assay	16891422	MGI
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	28904867	MGI
enables monoatomic cation channel activity	IPI IPI: Inferred from physical interaction	15548533	MGI
contributes to monoatomic cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	16891422	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	15548533	MGI
contributes to sour taste receptor activity	IDA IDA: Inferred from direct assay	16891422	MGI
enables transmembrane transporter binding	IPI IPI: Inferred from physical interaction	16891422	MGI

Biological Process GO Annotation	Evidence	References	Source
involved in cellular response to acidic pH	IDA IDA: Inferred from direct assay	16891422	MGI
involved in cellular response to pH	IDA IDA: Inferred from direct assay	28904867	MGI
involved in detection of chemical stimulus involved in sensory perception of sour taste	IDA IDA: Inferred from direct assay	16891422	MGI
involved in detection of chemical stimulus involved in sensory perception of taste	IMP IMP: Inferred from mutant phenotype	28553944	MGI
involved in inorganic cation transmembrane transport	IDA IDA: Inferred from direct assay	28904867	MGI
involved in monoatomic cation transport	IDA IDA: Inferred from direct assay	16891422	MGI
involved in protein tetramerization	IDA IDA: Inferred from direct assay	29567962	MGI
involved in response to water	IMP IMP: Inferred from mutant phenotype	28553944	MGI
involved in smoothened signaling pathway	IMP IMP: Inferred from mutant phenotype	24336288	MGI

Cellular Component GO Annotation	Evidence	References	Source
part of calcium channel complex	IDA IDA: Inferred from direct assay	29567962	MGI
part of calcium channel complex	IMP IMP: Inferred from mutant phenotype	24336288	MGI
part of cation channel complex	IDA IDA: Inferred from direct assay	16891422	MGI
colocalizes with cell surface	IDA IDA: Inferred from direct assay	16891422	MGI
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15548533	MGI
located in plasma membrane	IDA IDA: Inferred from direct assay	28904867	MGI
located in plasma membrane	IPI IPI: Inferred from physical interaction	15548533	MGI
part of receptor complex	IDA IDA: Inferred from direct assay	16891422	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
polycystic kidney disease 2-like 1 protein	polycystin-2 homolog polycystin-L

Pkd2l1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	Pkd2l1	A2A259	Pkd2l1	Mus musculus	A2A259	Anti Tag CoIP	16891422

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10594	PKD2L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pkd2l1	NCBI	NCBI:9033