2. Gene
  3. NLRP9 - NLR family pyrin domain containing 9 Gene

NLRP9 - NLR family pyrin domain containing 9 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as NOD6; NALP9; PAN12; CLR19.1

Gene ID: 338321 | Gene type: protein coding

About NLRP9

Cytogenetic location: 19q13.42 Genomic coordinates (GRCh38): 19:55,708,438-55,738,402 (from NCBI)

This gene has 2 transcripts (splice variants), 77 orthologues and 20 paralogues. Biased expression in prostate (RPKM 1.0), testis (RPKM 0.4) and 9 other tissues.

Summary

The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, Caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]

NLRP9 Products(1)

mRNA Protein Name
NM_176820.4 NP_789790.2 NACHT, LRR and PYD domains-containing protein 9

NLRP9 Protein Structure

PYRIN

PYRIN: PAAD/DAPIN/Pyrin domain (8 - 90)

NACHT

NACHT: NACHT domain (146 - 311)

LRR_6

LRR_6: Leucine Rich repeat (799 - 820)

LRR_6

LRR_6: Leucine Rich repeat (857 - 877)

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  • 991 a.a.
Protein Preferred Names Protein Names

NACHT, LRR and PYD domains-containing protein 9

NACHT, LRR and PYD containing protein 9

Related Diseases

Diseases Alias
Night Blindness, Congenital Stationary, Type 1d

Congenital Stationary Night Blindness 1d

CSNB1D

Csnb, Complete, Autosomal Recessive

Night Blindness, Congenital Stationary , 1d, Autosomal Recessive

Congenital Stationary Night Blindness 1d Autosomal Recessive

Night Blindness, Congenital Stationary, 1d

Complete Autosomal Recessive Csnb

Blindness, Night, Stationary, Congenital, Type 1d
Petrositis

Acute Petrositis

Chronic Petrositis

Inflammation Of Petrous Bone

Osteitis Of Petrous Bone

Osteomyelitis Of Petrous Bone
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09364 NLRP9 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris NLRP9 VGNC VGNC:43852
Rattus norvegicus NLRP9 RGD RGD:1308981
Felis catus NLRP9 VGNC VGNC:63833
Bos taurus NLRP9 VGNC VGNC:32121