SLC6A18 - solute carrier family 6 member 18 Gene

Homo sapiens

Also known as Xtrp2

Gene ID: 348932 | Gene type: protein coding

About SLC6A18

Cytogenetic location: 5p15.33 Genomic coordinates (GRCh38): 5:1,225,381-1,246,189 (from NCBI)

This gene has 2 transcripts (splice variants), 232 orthologues, 19 paralogues and is associated with 1 phenotype. Restricted expression toward kidney (RPKM 7.1).

Summary

The SLC6 family of proteins, which includes SLC6A18, act as specific transporters for neurotransmitters, Amino acids, and osmolytes like betaine, taurine, and creatine. SLC6 proteins are sodium cotransporters that derive the energy for solute transport from the electrochemical gradient for sodium ions (Hoglund et al., 2005 [PubMed 16125675]).[supplied by OMIM, Apr 2010]

SLC6A18 Products(1)

mRNA	Protein	Name
NM_182632.3	NP_872438.2	inactive sodium-dependent neutral amino acid transporter B(0)AT3

SLC6A18 Protein Structure

SNF

0
100
200
300
400
500
628 a.a.

Protein Preferred Names

Protein Names

inactive sodium-dependent neutral amino acid transporter B(0)AT3

sodium channel-like protein

Related Diseases

Diseases

Alias

Iminoglycinuria

Iminoglycinuria, Digenic

Hyperglycinuria

Glycinuria With Or Without Oxalate Urolithiasis	Glycinuria With Or Without Oxalate Nephrolithiasis
Iminoglycinuria Type Ii	HG

Fanconi-Like Syndrome

Fanconi Like Syndrome

Hartnup Disorder

Hartnup Disease	HND
Neutral 1 Amino Acid Transport Defect	Neutral Amino Acid Transport Defect
Deficiency Of Tryptophan Oxygenase	Hartnup'S Disease
Aminoaciduria, Hartnup Type	Disorder Of Neutral Amino Acid Transport

Developmental And Epileptic Encephalopathy 3

Epileptic Encephalopathy, Early Infantile, 3	DEE3
Eiee3	Early Myoclonic Encephalopathy
Developmental And Epileptic Encephalopathy, 3	Early Infantile Epileptic Encephalopathy 3
Eme	Neonatal Epilepsy With Suppression-Burst Pattern
Encephalopathy, Epileptic, Early Infantile, Type 3

Retinitis Pigmentosa 68

RP68	Retinitis Pigmentosa, Type 68

Hyperekplexia

Hereditary Hyperekplexia	Kok Disease
Congenital Stiff Man Syndrome	Familial Startle Disease
Sthe	Stiff-Baby Syndrome
Hereditary Hyperexplexia	Startle Disease
Exaggerated Startle Reaction	Hyperexplexia Hereditary
Startle Disease, Familial	Startle Reaction, Exaggerated
Stiff-Man Syndrome, Congenital	Stiff-Person Syndrome, Congenital
Congenital Stiff-Man Syndrome	Congenital Stiff-Person Syndrome
Familial Hyperekplexia	Startle Syndrome
Stiff Baby Syndrome	Hyperekplexia, Hereditary
Stiff-Person Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13304	SLC6A18 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC6A18	MGD	MGI:1336892
Canis familiaris	SLC6A18	VGNC	VGNC:46460
Macaca mulatta	SLC6A18	VGNC	VGNC:77779
Rattus norvegicus	SLC6A18	RGD	RGD:69352
Felis catus	SLC6A18	VGNC	VGNC:102323

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