IL11RA - interleukin 11 receptor subunit alpha Gene

Also Known as CRSDA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3590

About IL11RA

Cytogenetic location: 9p13.3 Genomic coordinates (GRCh38): 9:34,652,185-34,661,902 (from NCBI)

This gene has 27 transcripts (splice variants), 413 orthologues, 23 paralogues and is associated with 3 phenotypes. Ubiquitous expression in heart (RPKM 21.3), skin (RPKM 17.1) and 24 other tissues.

Summary

Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 Receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]

IL11RA Products (1)

mRNA	Protein	Name
NM_001142784.3	NP_001136256.1	interleukin-11 receptor subunit alpha precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables interleukin-11 receptor activity	IDA IDA: Inferred from direct assay	8637716	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in developmental process	IMP IMP: Inferred from mutant phenotype	21741611	GOA
involved in head development	IMP IMP: Inferred from mutant phenotype	21741611	GOA
involved in interleukin-11-mediated signaling pathway	IDA IDA: Inferred from direct assay	8637716	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names	Protein Names
interleukin-11 receptor subunit alpha	IL-11 receptor subunit alpha

IL11RA Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	IL11RA	Q14626	OLFM4	Homo sapiens	Q6UX06	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL11RA Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76416	IL-11R alpha Protein, Human (HEK293, His)	Q14626-1/NP_004503.1 (S23-V363)	≥ 95%, as determined by reducing SDS-PAGE.

IL11RA Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83347	IL-11 Receptor alpha Antibody (YA3092)	WB, IHC-P	Human
HY-P83347A	IL-11 Receptor alpha Antibody (YA3092)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Craniosynostosis And Dental Anomalies	Kreiborg-Pakistani Syndrome CRSDA Craniosynostosis-Dental Anomalies
Craniosynostosis	Premature Closure Of Cranial Sutures Craniostenosis Craniosynostosis Syndrome Cso Craniosynostoses Congenital Ossification Of Cranial Sutures Congenital Ossification Of Sutures Of Skull Craniostosis Imperfect Fusion Of Skull Congenital Imperfect Closure Skull Imperfect Closure Skull Premature Closure Cranium Sutures Deficiency Of Craniofacial Axis
Hyper Ige Recurrent Infection Syndrome 4
Epilepsy, Familial Temporal Lobe, 2	Familial Temporal Lobe Epilepsy 2 Temporal Epilepsy, Familial ETL2 Ftle Epilepsy, Familial Temporal Lobe Familial Temporal Lobe Epilepsy
Intellectual Developmental Disorder, Autosomal Dominant 22	MRD22 Mental Retardation, Autosomal Dominant 22 Autosomal Dominant Non-Syndromic Intellectual Disability 22 Distal Monosomy 1q Autosomal Dominant Intellectual Developmental Disorder 22 Autosomal Dominant Mental Retardation 22 Distal Deletion 1q Monosomy 1qter Telomeric Deletion 1q Mental Retardation, Autosomal Dominant, Type 22
Microphthalmia, Syndromic 3	MCOPS3 Aeg Syndrome Microphthalmia And Esophageal Atresia Syndrome Anophthalmia/Microphthalmia-Esophageal Atresia Syndrome Anophthalmia-Esophageal-Genital Syndrome Optic Nerve Hypoplasia And Abnormalities Of The Central Nervous System Syndromic Microphthalmia 3 Sox2 Anophthalmia Syndrome Anophthalmia Clinical With Associated Anomalies Anophthalmia Esophageal Genital Syndrome Anophthalmia Microphthalmia Esophageal Atresia Syndromic Microphthalmia Type 3 Sox2-Related Eye Disorders Anophthalmia, Clinical, With Associated Anomalies Syndromic Microphthalmia, Type 3 Microphthalmia, Syndromic, 3 Anophthalmia/Microphthalmia-Esophageal Atresia Microphthalmia Syndromic, Type 3
Crouzon Syndrome	Crouzon Craniofacial Dysostosis Craniofacial Dysostosis Cfd1 Craniofacial Dysostosis Type 1 Crouzon Disease Crouzon'S Disease Craniofacial Dysostosis, Type I Craniofacial Dysarthrosis Craniofacial Dysostosis Syndrome CS Craniofacial Dysostosis Type I Vogt Cephalosyndactyly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06676	IL11RA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-174643	Human IL11RA mRNA		/	Unkown

Inhibitory Antibodies (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991219	Anti-IL11RA Antibody (X209)	Inhibitor	97.75%	Unkown
HY-P992235	Anti-IL11RA Antibody (Hu16E12)	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	IL11RA	RGD	RGD:621332
Felis catus	IL11RA	VGNC	VGNC:102939
Bos taurus	IL11RA	VGNC	VGNC:30109
Canis familiaris	IL11RA	VGNC	VGNC:41931
Others	IL11RA	NCBI