Arhgdia - Rho GDP dissociation inhibitor alpha Gene

Also Known as Bles01; Rho GDI 1

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 360678

Summary

Enables HSP90 protein binding activity; enzyme binding activity; and fatty acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to redox state; and regulation of cell shape. Located in cytosol; extracellular space; and membrane. Is active in synapse. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Arhgdia Products (1)

mRNA Protein Name
NM_001007005.1 NP_001007006.1 rho GDP-dissociation inhibitor 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables Hsp90 protein binding IDA
IDA: Inferred from direct assay
19910677 RGD
enables fatty acid binding IDA
IDA: Inferred from direct assay
18084788 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
20696765 RGD
enables protein kinase binding IDA
IDA: Inferred from direct assay
9447972 RGD
enables small GTPase binding IPI
IPI: Inferred from physical interaction
17379756 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to mechanical stimulus IMP
IMP: Inferred from mutant phenotype
18566890 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
22960606 RGD
involved in cellular response to redox state IEP
IEP: Inferred from expression pattern
9665834 RGD
involved in negative regulation of cell migration IMP
IMP: Inferred from mutant phenotype
20696765 RGD
involved in regulation of cell shape IMP
IMP: Inferred from mutant phenotype
23012358 RGD
Cellular Component GO Annotation Evidence References Source
located in extracellular space IDA
IDA: Inferred from direct assay
23633624 RGD
is active in synapse EXP
EXP: Inferred from Experiment
24876496 RGD
is active in synapse IDA
IDA: Inferred from direct assay
24876496 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

rho GDP-dissociation inhibitor 1

  • Rho GDP dissociation inhibitor (GDI) alpha

  • rho-GDI alpha

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-180371 NF-115 Inducer / Unkown
HY-RS00943 ARHGDIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Arhgdia NCBI NCBI:396