Arhgdia - Rho GDP dissociation inhibitor alpha Gene

Rattus norvegicus

Also known as Bles01; Rho GDI 1

Gene ID: 360678 | Gene type: protein coding

About Arhgdia

Summary

Enables HSP90 protein binding activity; enzyme binding activity; and fatty acid binding activity. Involved in several processes, including cellular response to mechanical stimulus; cellular response to redox state; and regulation of cell shape. Located in cytosol; extracellular space; and membrane. Is active in synapse. Biomarker of hypertension. Human ortholog(s) of this gene implicated in nephrotic syndrome type 8. Orthologous to human ARHGDIA (Rho GDP dissociation inhibitor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Arhgdia Products(1)

mRNA	Protein	Name
NM_001007005.1	NP_001007006.1	rho GDP-dissociation inhibitor 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables Hsp90 protein binding	IDA IDA: Inferred from direct assay	19910677	RGD
enables fatty acid binding	IDA IDA: Inferred from direct assay	18084788	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	20696765	RGD
enables protein kinase binding	IDA IDA: Inferred from direct assay	9447972	RGD
enables small GTPase binding	IPI IPI: Inferred from physical interaction	17379756	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mechanical stimulus	IMP IMP: Inferred from mutant phenotype	18566890	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	22960606	RGD
involved in cellular response to redox state	IEP IEP: Inferred from expression pattern	9665834	RGD
involved in negative regulation of cell migration	IMP IMP: Inferred from mutant phenotype	20696765	RGD
involved in regulation of cell shape	IMP IMP: Inferred from mutant phenotype	23012358	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	23633624	RGD
is active in synapse	EXP EXP: Inferred from Experiment	24876496	RGD
is active in synapse	IDA IDA: Inferred from direct assay	24876496	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

rho GDP-dissociation inhibitor 1

Rho GDP dissociation inhibitor (GDI) alpha

rho-GDI alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00943	ARHGDIA Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Arhgdia	NCBI	NCBI:396

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