Slc25a12 - solute carrier family 25 member 12 Gene

Also Known as Aralar1; RGD1561141

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 362145

Summary

Predicted to enable acidic amino acid transmembrane transporter activity; calcium ion binding activity; and identical protein binding activity. Involved in several processes, including malate-aspartate shuttle; positive regulation of ATP biosynthetic process; and regulation of glucose metabolic process. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in Asperger syndrome; autistic disorder; and developmental and epileptic encephalopathy 39. Orthologous to human SLC25A12 (solute carrier family 25 member 12). [provided by Alliance of Genome Resources, Apr 2022]

Slc25a12 Products (1)

mRNA Protein Name
NM_001399269.1 NP_001386198.1 electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in glutamate biosynthetic process IMP
IMP: Inferred from mutant phenotype
19764902 RGD
involved in malate-aspartate shuttle IMP
IMP: Inferred from mutant phenotype
19764902 RGD
involved in negative regulation of glucose catabolic process to lactate via pyruvate IMP
IMP: Inferred from mutant phenotype
19764902 RGD
involved in positive regulation of ATP biosynthetic process IMP
IMP: Inferred from mutant phenotype
19764902 RGD
involved in positive regulation of glucose metabolic process IMP
IMP: Inferred from mutant phenotype
19764902 RGD
involved in positive regulation of myelination IMP
IMP: Inferred from mutant phenotype
20015484 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

calcium-binding mitochondrial carrier protein Aralar1

  • solute carrier family 25 (aspartate/glutamate carrier), member 12

  • solute carrier family 25 (mitochondrial carrier, Aralar), member 12

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13092 SLC25A12 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20672 Slc25a12 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27183 Slc25a12 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Slc25a12 NCBI NCBI:8604