KCTD8 - potassium channel tetramerization domain containing 8 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 386617

About KCTD8

Cytogenetic location: 4p13 Genomic coordinates (GRCh38): 4:44,173,903-44,448,809 (from NCBI)

This gene has 2 transcripts (splice variants), 160 orthologues and 13 paralogues. Biased expression in brain (RPKM 3.7), thyroid (RPKM 1.4) and 7 other tissues.

Summary

Predicted to be involved in regulation of G protein-coupled receptor signaling pathway. Predicted to be located in cell projection; postsynaptic membrane; and presynaptic membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. [provided by Alliance of Genome Resources, Apr 2022]

KCTD8 Products (1)

mRNA Protein Name
NM_198353.3 NP_938167.1 BTB/POZ domain-containing protein KCTD8

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCTD8 Protein Structure

BTB_2

BTB_2: BTB/POZ domain (46 - 142)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 473 a.a.
Protein Preferred Names Protein Names

BTB/POZ domain-containing protein KCTD8

  • potassium channel tetramerisation domain containing 8

KCTD8 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
KCTD8 Q6ZWB6 YWHAE Homo sapiens P62258
Crosslink
36931259
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Scalp-Ear-Nipple Syndrome

  • Finlay-Marks Syndrome

  • Sen Syndrome

  • SENS

  • Scalp Ear Nipple Syndrome

  • Hereditary Syndrome Of Lumpy Scalp, Odd Ears And Rudimentary Nipples

  • Hereditary Syndrome Of Lumpy Scalp, Odd Ears, And Rudimentary Nipples

  • Indian Childhood Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS07199 KCTD8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris KCTD8 VGNC VGNC:42311
Mus musculus KCTD8 MGD MGI:2443804
Rattus norvegicus KCTD8 RGD RGD:1312020
Macaca mulatta KCTD8 VGNC VGNC:73888
Bos taurus KCTD8 VGNC VGNC:59339
Felis catus KCTD8 VGNC VGNC:78518
Others KCTD8 NCBI