AGMO - alkylglycerol monooxygenase Gene

Homo sapiens

Also known as TMEM195

Gene ID: 392636 | Gene type: protein coding

About AGMO

Cytogenetic location: 7p21.2 Genomic coordinates (GRCh38): 7:15,117,223-15,562,015 (from NCBI)

This gene has 4 transcripts (splice variants) and 204 orthologues. Biased expression in liver (RPKM 8.7), small intestine (RPKM 2.1) and 4 other tissues.

Summary

The protein encoded by this gene is a tetrahydrobiopterin- and iron-dependent Enzyme that cleaves the ether bond of alkylglycerols. Sequence comparisons distinguish this protein as forming a third, distinct class of tetrahydrobiopterin-dependent enzymes. Variations in this gene have been associated with decreased glucose-stimulated Insulin response, type 2 diabetes, and susceptibility to intracranial aneurysms. [provided by RefSeq, Aug 2012]

AGMO Products(1)

mRNA	Protein	Name
NM_001004320.2	NP_001004320.1	alkylglycerol monooxygenase

AGMO Protein Structure

FA_hydroxylase

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

alkylglycerol monooxygenase

glyceryl-ether monooxygenase

Related Diseases

Diseases

Alias

Dystonia, Dopa-Responsive, Due To Sepiapterin Reductase Deficiency

Sepiapterin Reductase Deficiency	Spr Deficiency
Dopa-Responsive Dystonia Due To Sepiapterin Reductase Deficiency	Srd
Drd Due To Srd	Dopa-Responsive Hypersomnia
Dyt-Spr	Dyt/Park-Spr
Sr-Deficient Drd	Autosomal Recessive Sepiapterin Reductase-Deficient Drd
Spr	DRDSPRD
Motor And Cognitive Disorder Due To Sepiapterin Reductase Deficiency	Psychomotor Disorders

Sjogren-Larsson Syndrome

Sjögren-Larsson Syndrome	SLS
Faldh Deficiency	Fatty Aldehyde Dehydrogenase Deficiency
Fatty Acid Alcohol Oxidoreductase Deficiency	Ichthyosis, Spastic Neurologic Disorder, And Oligophrenia
Sjogren Larsson Syndrome	Fatty Alcohol:Nad+ Oxidoreductase Deficiency
Sjogren-Larsson'S Syndrome	Fadh Deficiency
Fao Deficiency	Congenital Icthyosis Mental Retardation Spasticity Syndrome
Ichthyosis Oligophrenia Syndrome	Sjoegren-Larsson Syndrome

Microcephaly

Microencephaly	Microcephalus
Microcephalic	Nanocephaly
Congenital Microcephaly	Brain Hypoplasia
Brain Nondevelopment	Cephalic Hypoplasia
Undeveloped Cerebrum	Undeveloped Brain
Micrencephalon	Micrencephaly

Primary Autosomal Recessive Microcephaly

Autosomal Recessive Primary Microcephaly	Mcph
True Microcephaly	Microcephalia Vera
Microcephaly Vera	Microcephaly Primary Hereditary
Microcephaly, Primary, Autosomal Recessive	Primary Microcephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00451	AGMO Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AGMO	VGNC	VGNC:37706
Bos taurus	AGMO	VGNC	VGNC:25731
Felis catus	AGMO	VGNC	VGNC:59684
Mus musculus	AGMO	MGD	MGI:2442495
Rattus norvegicus	AGMO	RGD	RGD:1312038
Macaca mulatta	AGMO	VGNC	VGNC:69754