LMO7 - LIM domain 7 Gene

Also Known as LOMP; FBX20; LMO7b; FBXO20

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4008

About LMO7

Cytogenetic location: 13q22.2 Genomic coordinates (GRCh38): 13:75,620,434-75,859,870 (from NCBI)

This gene has 27 transcripts (splice variants), 326 orthologues and 1 paralogue. Broad expression in lung (RPKM 43.5), esophagus (RPKM 32.9) and 17 other tissues.

Summary

This gene encodes a protein containing a calponin homology (CH) domain, a PDZ domain, and a LIM domain, and may be involved in protein-protein interactions. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, however, the full-length nature of some variants is not known. [provided by RefSeq, Jan 2009]

LMO7 Products (8)

mRNA	Protein	Name
NM_001306080.2	NP_001293009.1	LIM domain only protein 7 isoform 3
NM_001330583.1	NP_001317512.1	LIM domain only protein 7 isoform 4
NM_001366632.2	NP_001353561.1	LIM domain only protein 7 isoform 2
NM_001366633.2	NP_001353562.1	LIM domain only protein 7 isoform 5
NM_001366634.2	NP_001353563.1	LIM domain only protein 7 isoform 6
NM_001366636.2	NP_001353565.1	LIM domain only protein 7 isoform 6
NM_005358.5	NP_005349.3	LIM domain only protein 7 isoform 1
NM_015842.2	NP_056667.2	LIM domain only protein 7 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	15161933	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17067998	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	17067998	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	17067998	GOA
located in nuclear envelope	IDA IDA: Inferred from direct assay	17067998	GOA
located in nucleus	IDA IDA: Inferred from direct assay	17067998	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMO7 Protein Structure

PDZ

0
300
600
900
1200
1385 a.a.

Protein Preferred Names	Protein Names
LIM domain only protein 7	F-box only protein 20

LMO7 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LMO7	Q8WWI1	YWHAZ	Homo sapiens	P63104	Pull Down	15161933

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Townes-Brocks Syndrome	Townes Syndrome Renal-Ear-Anal-Radial Syndrome Anus, Imperforate, With Hand, Foot And Ear Anomalies Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome Rear Syndrome Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs Tbs Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs Imperforate Anus With Hand, Foot And Ear Anomalies Anal-Ear-Renal-Radial Malformation Syndrome Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Imperforate Anus-Hand And Foot Anomalies Syndrome Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs
Hyperalphalipoproteinemia 1	Hyperalphalipoproteinemia HALP1 Cetp Deficiency Cholesterol-Ester Transfer Protein Deficiency Familial Hyperalphalipoproteinemia Cholesteryl Ester Transfer Protein Deficiency Cept Deficiency Cholesterol Ester Transfer Protein Deficiency
Cardiomyopathy, Dilated, 1dd	Dilated Cardiomyopathy 1dd CMD1DD Cardiomyopathy, Dilated 1dd Cardiomyopathy, Dilated, Type 1dd
Astigmatism
Emery-Dreifuss Muscular Dystrophy 1, X-Linked	EDMD1 Emd1 Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures X-Linked Emery-Dreifuss Muscular Dystrophy 1 Humeroperoneal Neuromuscular Disease X-Linked Emery-Dreifuss Muscular Dystrophy Scapuloperoneal Syndrome, X-Linked, Formerly Humeroperoneal Neuromuscular Disease, Formerly Scapuloperoneal Syndrome, X-Linked Muscular Dystrophy Tardive Dreifuss-Emery Type With Contractures Scapuloperoneal Syndrome X-Linked X-Edmd Dystrophy, Muscular, Emery-Dreifuss, Type 1, X-Linked
Emery-Dreifuss Muscular Dystrophy	Edmd Emery-Dreifuss Syndrome Muscular Dystrophy, Emery-Dreifuss Humeroperoneal Neuromuscular Disease Muscular Dystrophy, Tardive, Dreifuss-Emery Type, With Contractures Scapuloperoneal Syndrome, X-Linked Benign Scapuloperoneal Muscular Dystrophy With Early Contractures Muscular Dystrophy, Emery-Dreifuss Type Muscular Dystrophy Emery-Dreifuss Dystrophy, Muscular, Emery-Dreifuss Emd - [Emery-Dreifuss Muscular Dystrophy]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07721	LMO7 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	LMO7	RGD	RGD:1302984
Felis catus	LMO7	VGNC	VGNC:68073
Mus musculus	LMO7	MGD	MGI:1353586
Bos taurus	LMO7	VGNC	VGNC:30937
Macaca mulatta	LMO7	VGNC	VGNC:74433
Canis familiaris	LMO7	VGNC	VGNC:42725
Others	LMO7	NCBI