MAGEA10 - MAGE family member A10 Gene

Homo sapiens

Also known as CT1.10; MAGE10

Gene ID: 4109 | Gene type: protein coding

About MAGEA10

Cytogenetic location: Xq28 Genomic coordinates (GRCh38): X:152,133,310-152,138,577 (from NCBI)

This gene has 6 transcripts (splice variants), 208 orthologues and 37 paralogues. Biased expression in placenta (RPKM 4.9) and testis (RPKM 1.2).

Summary

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the downstream melanoma antigen family A, 5 (MAGEA5) gene.[provided by RefSeq, Oct 2011]

MAGEA10 Products(3)

mRNA	Protein	Name
NM_001011543.3	NP_001011543.3	melanoma-associated antigen 10
NM_001251828.2	NP_001238757.2	melanoma-associated antigen 10
NM_021048.5	NP_066386.3	melanoma-associated antigen 10

MAGEA10 Protein Structure

MAGE_N

MAGE

0
100
200
300
369 a.a.

Protein Preferred Names

Protein Names

melanoma-associated antigen 10

MAGE-10 antigen

Related Diseases

Diseases

Alias

Melanoma

Malignant Melanoma	Cutaneous Melanoma
Naevocarcinoma	Malignant Melanomas

Dyskeratosis Congenita

Dyskeratosis Congenita Autosomal Dominant	Dc
Dkc	Zinsser-Engman-Cole Syndrome
Dyskeratosis Congenita, Autosomal Dominant	Autosomal Dominant Dyskeratosis Congenita
Dkca	Dyskeratosis Congenita Scoggins Type
Zinsser-Cole-Engman Syndrome	X-Linked Dyskeratosis Congenita
Hoyeraal-Hreidarsson Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07965	MAGEA10 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	MAGEA10	RGD	RGD:1563693

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