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METTL1 - methyltransferase 1, tRNA methylguanosine Gene

Also Known as TRM8; TRMT8; C12orf1; YDL201w

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4234

About METTL1

Cytogenetic location: 12q14.1 Genomic coordinates (GRCh38): 12:57,768,471-57,772,105 (from NCBI)

This gene has 8 transcripts (splice variants) and 190 orthologues. Ubiquitous expression in kidney (RPKM 7.6), thyroid (RPKM 7.3) and 25 other tissues.

Summary

This gene is similar in sequence to the S. cerevisiae YDL201w gene. The gene product contains a conserved S-adenosylmethionine-binding motif and is inactivated by phosphorylation. Alternative splice variants encoding different protein isoforms have been described for this gene. A pseudogene has been identified on chromosome X. [provided by RefSeq, Jul 2008]

METTL1 Products (2)

mRNA	Protein	Name
NM_005371.6	NP_005362.3	tRNA (guanine-N(7)-)-methyltransferase isoform a
NM_023033.4	NP_075422.3	tRNA (guanine-N(7)-)-methyltransferase isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables internal mRNA (guanine-N7-)-methyltransferase activity	IDA IDA: Inferred from direct assay	31031084	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15861136	GOA
enables tRNA (guanine(46)-N7)-methyltransferase activity	IDA IDA: Inferred from direct assay	12403464	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA (guanine-N7)-methylation	IDA IDA: Inferred from direct assay	37379838	GOA
involved in cellular response to stress	IDA IDA: Inferred from direct assay	37379838	GOA
involved in tRNA (guanine-N7)-methylation	IDA IDA: Inferred from direct assay	36599982	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	12403464	GOA
involved in tRNA stabilization	IDA IDA: Inferred from direct assay	36599982	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15861136	GOA
part of tRNA (m7G46) methyltransferase complex	IDA IDA: Inferred from direct assay	36599982	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

METTL1 Protein Structure

Methyltransf_4

0
100
200
276 a.a.

Protein Preferred Names	Protein Names
tRNA (guanine-N(7)-)-methyltransferase	D1075-like gene product

METTL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	METTL1	Q9UBP6	WDR4	Homo sapiens	P57081	Y2H Array	32296183
Intra	METTL1	Q9UBP6	WDR4	Homo sapiens	P57081	Y2H Pooling	16189514
Intra	METTL1	Q9UBP6	WDR4	Homo sapiens	P57081	Y2H Array	31515488
Intra	METTL1	Q9UBP6	WDR4	Homo sapiens	P57081	Anti Tag CoIP	33961781
Intra	METTL1	Q9UBP6	WDR4	Homo sapiens	P57081	Validated Y2H	25416956
Intra	METTL1	Q9UBP6	WDR4	Homo sapiens	P57081	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant METTL1 Proteins

Cat. No.	상품명	Accession	Purity
HY-P75926	METTL1 Protein, Human (His)	Q9UBP6-1/NP_005362.3 (D32-Q265)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	상품명	효과	Purity	Rare Diseases
HY-162080	METTL1-WDR4-IN-1	Inhibitor	99.61%	Unkown
HY-162082	METTL1-WDR4-IN-2	Inhibitor	99.14%	Unkown
HY-178159	SA91-0178	Inhibitor	98.14%	Unkown
HY-162080A	METTL1-WDR4-IN-1 TFA	Inhibitor	99.61%	Unkown
HY-178947	ZINC13000658		99.78%	Unkown
HY-RS08353	METTL1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS17432	Mettl1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23887	Mettl1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	METTL1	MGD	MGI:1339986
Bos taurus	METTL1	VGNC	VGNC:31400
Rattus norvegicus	METTL1	RGD	RGD:1593036
Macaca mulatta	METTL1	VGNC	VGNC:100078
Canis familiaris	METTL1	VGNC	VGNC:43169
Others	METTL1	NCBI