country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

WDR4 - WD repeat domain 4 Gene

Also Known as hWH; Wuho; MIGSB; TRM82; GAMOS6; TRMT82

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10785

About WDR4

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,843,094-42,892,998 (from NCBI)

This gene has 7 transcripts (splice variants), 189 orthologues and is associated with 4 phenotypes. Ubiquitous expression in lymph node (RPKM 3.3), appendix (RPKM 3.2) and 25 other tissues.

Summary

This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 Amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, Apoptosis, and gene regulation. This gene is excluded as a candidate for a form of nonsyndromic deafness (DFNB10), but is still a candidate for Other disorders mapped to 21q22.3 as well as for the development of Down syndrome phenotypes. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2012]

WDR4 Products (6)

mRNA	Protein	Name
NM_001260474.2	NP_001247403.1	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 2
NM_001260475.2	NP_001247404.1	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 3
NM_001260476.2	NP_001247405.1	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 3
NM_001260477.2	NP_001247406.1	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 3
NM_018669.6	NP_061139.2	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 1
NM_033661.5	NP_387510.1	tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables enzyme activator activity	IDA IDA: Inferred from direct assay	36599982	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15861136	GOA
enables tRNA methyltransferase activator activity	IDA IDA: Inferred from direct assay	36599982	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in tRNA (guanine-N7)-methylation	IDA IDA: Inferred from direct assay	36599982	GOA
involved in tRNA modification	IDA IDA: Inferred from direct assay	15861136	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	IDA IDA: Inferred from direct assay	15861136	GOA
part of tRNA (m7G46) methyltransferase complex	IDA IDA: Inferred from direct assay	36599982	GOA
part of tRNA methyltransferase complex	IDA IDA: Inferred from direct assay	12403464	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR4 Protein Structure

WD40

0
100
200
300
412 a.a.

Protein Preferred Names	Protein Names
tRNA (guanine-N(7)-)-methyltransferase non-catalytic subunit WDR4	TRM82 tRNA methyltransferase 82 homolog

WDR4 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	WDR4	P57081	RABGGTB	Homo sapiens	P53611	Y2H Prey Pooling	25416956
Intra	WDR4	P57081	RABGGTB	Homo sapiens	P53611	Y2H Prey Pooling	32296183
Intra	WDR4	P57081	RABGGTB	Homo sapiens	P53611	Y2H Array	25416956
Intra	WDR4	P57081	RABGGTB	Homo sapiens	P53611	Y2H Array	32296183
Intra	WDR4	P57081	FEN1	Homo sapiens	P39748	Pull Down	26751069
Intra	WDR4	P57081	FEN1	Homo sapiens	P39748	Fluorescence Spectr	26751069
Intra	WDR4	P57081	FEN1	Homo sapiens	P39748	Anti Tag CoIP	26751069
Intra	WDR4	P57081	FEN1	Homo sapiens	P39748	Anti Bait CoIP	26751069
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Y2H Prey Pooling	32296183
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Y2H Prey Pooling	25416956
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Validated Y2H	32296183
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Y2H Array	25416956
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Y2H Array	32296183
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Anti Tag CoIP	33961781
Intra	WDR4	P57081	METTL1	Homo sapiens	Q9UBP6	Anti Tag CoIP	26751069
Intra	WDR4	P57081	FAM118A	Homo sapiens	Q9NWS6	Y2H Array	25416956
Intra	WDR4	P57081	FAM118A	Homo sapiens	Q9NWS6	Y2H Array	32296183
Intra	WDR4	P57081	FAM118A	Homo sapiens	Q9NWS6	Validated Y2H	32296183
Intra	WDR4	P57081	FAM118A	Homo sapiens	Q9NWS6	Y2H Prey Pooling	25416956
Intra	WDR4	P57081	FAM118A	Homo sapiens	Q9NWS6	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

WDR4 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83179	WDR4 Antibody (YA2924)	WB, IHC-P, ICC/IF, FC	Human

Related Diseases

Diseases	Alias
Microcephaly, Growth Deficiency, Seizures, And Brain Malformations	MIGSB
Galloway-Mowat Syndrome 6	GAMOS6
Galloway-Mowat Syndrome	Galloway Mowat Syndrome Galloway Syndrome Hiatal Hernia-Microcephaly-Nephrosis, Galloway Type Microcephaly Nephrosis Syndrome Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Nephrosis Neuronal Dysmigration Syndrome Microcephaly-Hiatus Hernia-Nephrotic Syndrome Nephrosis-Neuronal Dysmigration Syndrome
Galloway-Mowat Syndrome 1	Galloway Syndrome Nephrosis-Neuronal Dysmigration Syndrome Nephrosis-Microcephaly Syndrome Camos Scar5 GAMOS1 Microcephaly, Hiatal Hernia, And Nephrotic Syndrome Microcephaly, Hiatal Hernia And Nephrotic Syndrome Cerebellar Ataxia With Mental Retardation, Optic Atrophy, And Skin Abnormalities Spinocerebellar Ataxia, Autosomal Recessive 5, Formerly Scar5, Formerly Spinocerebellar Ataxia Autosomal Recessive 5 Cerebellar Ataxia With Intellectual Disability Optic Atrophy And Skin Abnormalities Camos Syndrome Cerebellar Ataxia-Intellectual Disability-Optic Atrophy-Skin Abnormalities Syndrome Galloway-Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive, 5 Galloway Mowat Syndrome Spinocerebellar Ataxia, Autosomal Recessive 5
Seckel Syndrome	Microcephalic Primordial Dwarfism Bird-Headed Dwarfism Harper'S Syndrome Virchow-Seckel Dwarfism Nanocephalic Dwarfism Sckl Seckel-Type Dwarfism
Lissencephaly	Pachygyria Broad Gyri Of Cerebrum Large Gyri Of Cerebrum Macrogyria
Isolated Growth Hormone Deficiency, Type Ia	Ighd Ia Primordial Dwarfism Isolated Growth Hormone Deficiency Type Ia Sexual Ateleiotic Dwarfism Pituitary Dwarfism I IGHD1A Illig-Type Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, Type Ia Congenital Ighd Type Ia Congenital Isolated Gh Deficiency Type Ia Congenital Isolated Growth Hormone Deficiency Type Ia Pituitary Dwarfism 1 Growth Hormone Deficiency, Isolated, Autosomal Recessive Autosomal Recessive Isolated Growth Hormone Deficiency Isolated Growth Hormone Deficiency Type 1a Congenital Ighd Congenital Isolated Gh Deficiency Congenital Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated Autosomal Recessive Illig Type Growth Hormone Deficiency Non-Acquired Isolated Growth Hormone Deficiency Growth Hormone Deficiency, Isolated, 1a Growth Hormone Deficiency Isolated Autosomal Recessive Dwarfism, Primordial Dwarfism
Polymicrogyria	Pmg
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Non-Syndromic X-Linked Intellectual Disability	X-Linked Non-Syndromic Intellectual Disability Non-Specific X-Linked Mental Retardation X-Linked Non-Specific Intellectual Disability

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-162080	METTL1-WDR4-IN-1	Inhibitor	99.61%	Unkown
HY-162082	METTL1-WDR4-IN-2	Inhibitor	99.14%	Unkown
HY-162080A	METTL1-WDR4-IN-1 TFA	Inhibitor	99.61%	Unkown
HY-RS15777	WDR4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22359	Wdr4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28881	Wdr4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WDR4	VGNC	VGNC:81794
Bos taurus	WDR4	VGNC	VGNC:36897
Rattus norvegicus	WDR4	RGD	RGD:1585179
Canis familiaris	WDR4	VGNC	VGNC:48365
Mus musculus	WDR4	MGD	MGI:1889002
Felis catus	WDR4	VGNC	VGNC:67031
Others	WDR4	NCBI