MT1B - metallothionein 1B Gene

Also Known as MT1; MTP; MT1Q; MT-1B; MT-IB

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4490

About MT1B

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,651,886-56,653,204 (from NCBI)

This gene has 2 transcripts (splice variants), 213 orthologues and 11 paralogues. Biased expression in liver (RPKM 1.6), duodenum (RPKM 0.4) and 1 other tissue.

Summary

The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]

MT1B Products (1)

mRNA Protein Name
NM_005947.3 NP_005938.1 metallothionein-1B

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to zinc ion IEP
IEP: Inferred from expression pattern
11168427 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1B Protein Structure

Metallothio

Metallothio: Metallothionein (1 - 61)

  • 0
  • 61 a.a.
Protein Preferred Names Protein Names

metallothionein-1B

  • metallothionein 1B (functional)

MT1B Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MT1B P07438 KRTAP5-2 Homo sapiens Q701N4
Validated Y2H
32296183
Intra
MT1B P07438 KRTAP5-2 Homo sapiens Q701N4
Y2H Prey Pooling
32296183
Intra
MT1B P07438 KRTAP5-2 Homo sapiens Q701N4
Y2H Array
32296183
Intra
MT1B P07438 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
MT1B P07438 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
MT1B P07438 KRTAP1-1 Homo sapiens Q07627
Validated Y2H
32296183
Intra
MT1B P07438 KRTAP17-1 Homo sapiens Q9BYP8
Validated Y2H
32296183
Intra
MT1B P07438 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Array
32296183
Intra
MT1B P07438 KRTAP17-1 Homo sapiens Q9BYP8
Y2H Prey Pooling
32296183
Intra
MT1B P07438 KRTAP10-6 Homo sapiens P60371
Y2H Array
32296183
Intra
MT1B P07438 KRTAP10-6 Homo sapiens P60371
Y2H Prey Pooling
32296183
Intra
MT1B P07438 KRTAP10-6 Homo sapiens P60371
Validated Y2H
32296183
Intra
MT1B P07438 SMCP Homo sapiens P49901
Validated Y2H
32296183
Intra
MT1B P07438 SMCP Homo sapiens P49901
Y2H Array
32296183
Intra
MT1B P07438 SMCP Homo sapiens P49901
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08736 MT1B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MT1B MGD MGI:97171
Others MT1B NCBI