MT1X - metallothionein 1X Gene

Also Known as MT1; MT-1l

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4501

About MT1X

Cytogenetic location: 16q13 Genomic coordinates (GRCh38): 16:56,682,470-56,684,196 (from NCBI)

This gene has 4 transcripts (splice variants), 218 orthologues and 11 paralogues. Broad expression in liver (RPKM 301.6), kidney (RPKM 245.8) and 16 other tissues.

Summary

Predicted to enable copper ion binding activity and zinc ion binding activity. Involved in cellular response to cadmium ion; cellular response to erythropoietin; and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

MT1X Products (1)

mRNA Protein Name
NM_005952.4 NP_005943.1 metallothionein-1X

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
21044950 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to cadmium ion IEP
IEP: Inferred from expression pattern
16827180 GOA
involved in cellular response to erythropoietin IEP
IEP: Inferred from expression pattern
11168427 GOA
involved in cellular response to zinc ion IEP
IEP: Inferred from expression pattern
11168427 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
8619255 GOA
located in nucleus IDA
IDA: Inferred from direct assay
8619255 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MT1X Protein Structure

Metallothio

Metallothio: Metallothionein (1 - 61)

  • 0
  • 61 a.a.
Protein Preferred Names Protein Names

metallothionein-1X

  • MT-1X

MT1X Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
MT1X P80297 SIX6OS1 Homo sapiens Q8N1H7
Y2H Prey Pooling
32296183
Intra
MT1X P80297 SIX6OS1 Homo sapiens Q8N1H7
Validated Y2H
32296183
Intra
MT1X P80297 SIX6OS1 Homo sapiens Q8N1H7
Y2H Array
32296183
Intra
MT1X P80297 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
Intra
MT1X P80297 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Deficiency Anemia

  • Anemia

  • Deficiency Anemias

  • Anaemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS08742 MT1X Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MT1X MGD MGI:97171
Others MT1X NCBI