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MYO7B - myosin VIIB Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4648

About MYO7B

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:127,535,683-127,637,726 (from NCBI)

This gene has 7 transcripts (splice variants), 257 orthologues and 43 paralogues. Biased expression in duodenum (RPKM 42.9), small intestine (RPKM 30.6) and 5 other tissues.

Summary

The protein encoded by this gene is found in brush border microvilli of epithelial cells in the intestines and kidneys. The encoded protein is involved in linking protocadherins to the actin Cytoskeleton and is essential for proper microvilli function. This protein aids in the accumulation of intermicrovillar adhesion components such as harmonin and ANKS4B, and this accumulation is necessary for normal brush border action. [provided by RefSeq, Jan 2017]

MYO7B Products (3)

mRNA	Protein	Name
NM_001080527.2	NP_001073996.1	unconventional myosin-VIIb isoform 2
NM_001393586.1	NP_001380515.1	unconventional myosin-VIIb isoform 1
NM_001393594.1	NP_001380523.1	unconventional myosin-VIIb isoform 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24725409	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in brush border assembly	IDA IDA: Inferred from direct assay	32209652	GOA
involved in brush border assembly	IPI IPI: Inferred from physical interaction	24725409	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in brush border	IDA IDA: Inferred from direct assay	24725409	GOA
located in microvillus	IDA IDA: Inferred from direct assay	24725409	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MYO7B Protein Structure

Myosin_head

MyTH4

SH3_2

MyTH4

FERM_M

0
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800
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2116 a.a.

Protein Preferred Names	Protein Names
unconventional myosin-VIIb

Related Diseases

Diseases	Alias
Microvillus Inclusion Disease	Congenital Microvillous Atrophy Intractable Diarrhea Of Infancy Congenital Familial Protracted Diarrhea With Enterocyte Brush-Border Abnormalities Davidson Disease Microvillous Inclusion Disease Congenital Microvillus Atrophy Mvid Diarrhea 2 With Microvillus Atrophy Mvd Congenital Familial Protracted Diarrhea Davidson'S Disease Familial Enteropathy, Microvillus Microvillus Atrophy, Congenital Congenital Enteropathy Familial Protracted Enteropathy Microvillous Atrophy Microvillus Atrophy With Diarrhea 2 Idi
Usher Syndrome, Type Id	Usher Syndrome Type 1d USH1D Usher Syndrome, Type 1d Usher Syndrome Type Id Usher Syndrome, Type Id/F, Digenic Usher Syndrome, Type 1d/F Digenic Usher Syndrome 1d Usher'S Syndrome Type 1d Usher Syndrome 1d/F USH1DF Ush1d/F Usher'S Syndrome Type 1h Usher Syndrome 1h Usher Syndrome Type Ih Usher Syndrome, Type 1d/F
Usher Syndrome, Type I	USH1 Usher Syndrome Type 1 Us1 Usher Syndrome, Type 1b Usher Syndrome Type 1e Retinitis Pigmentosa And Congenital Deafness Usher Syndrome, Type Ie USH1E Usher Syndrome, Type 1e Usher Syndrome, Type 1a Usher Syndrome, Type Ib Usher Syndrome Type 1b Usher Syndrome Type Ie Usher Syndrome Type I Usher 1 Usher Syndrome, Type 1 Ush1a Usher Syndrome, Type I, French Variety Usher Syndrome, Type Ia Usher Syndrome 1b USH1B Usher'S Syndrome Type 1b Usher Syndrome Type Ib Ushib
Usher Syndrome	Deafness-Retinitis Pigmentosa Syndrome Dystrophia Retinae Pigmentosa-Dysostosis Syndrome Graefe-Usher Syndrome Hallgren Syndrome Usher'S Syndrome Retinitis Pigmentosa-Deafness Syndrome Retinitis Pigmentosa-Hearing Loss Syndrome Ush Usher Syndromes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08951	MYO7B Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MYO7B	VGNC	VGNC:31831
Macaca mulatta	MYO7B	VGNC	VGNC:99385
Rattus norvegicus	MYO7B	RGD	RGD:1561153
Felis catus	MYO7B	VGNC	VGNC:68400
Mus musculus	MYO7B	MGD	MGI:107709
Canis familiaris	MYO7B	VGNC	VGNC:43573