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NAB1 - NGFI-A binding protein 1 Gene

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4664

About NAB1

Cytogenetic location: 2q32.2 Genomic coordinates (GRCh38): 2:190,648,895-190,692,766 (from NCBI)

This gene has 10 transcripts (splice variants), 235 orthologues and 1 paralogue. Ubiquitous expression in skin (RPKM 20.8), esophagus (RPKM 13.9) and 25 other tissues.

Summary

Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to act upstream of or within endochondral ossification; nervous system development; and regulation of epidermis development. Predicted to be located in nucleoplasm. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

NAB1 Products (5)

mRNA	Protein	Name
NM_001321312.2	NP_001308241.1	NGFI-A-binding protein 1 isoform 1
NM_001321313.1	NP_001308242.1	NGFI-A-binding protein 1 isoform 1
NM_001321314.1	NP_001308243.1	NGFI-A-binding protein 1 isoform 2
NM_001321315.1	NP_001308244.1	NGFI-A-binding protein 1 isoform 3
NM_005966.4	NP_005957.2	NGFI-A-binding protein 1 isoform 1

NAB1 Protein Structure

NCD1

NCD2

Nab1

0
100
200
300
400
487 a.a.

Protein Preferred Names	Protein Names
NGFI-A-binding protein 1	EGR-1-binding protein 1

Related Diseases

Diseases	Alias
Brain Compression	Compression Of Brain
Neuropathy, Congenital Hypomyelinating, 1, Autosomal Recessive	Charcot-Marie-Tooth Disease Type 4 Charcot-Marie-Tooth Disease Type 4e Hereditary Motor And Sensory Neuropathy Cmt4e CHN1 Hypomyelinating Neuropathy, Congenital, 1 Charcot-Marie-Tooth Neuropathy Type 4e Neuropathy, Congenital Hypomyelinating, 1 Ar-Cmt1 Autosomal Recessive Demyelinating Charcot-Marie-Tooth Cmt4 Neuropathy, Congenital Hypomyelinating Or Amyelinating, Autosomal Recessive Hypomyelination, Severe Congenital Charcot-Marie-Tooth Disease, Type 4e Charcot-Marie-Tooth Neuropathy, Type 4e Autosomal Recessive Congenital Hypomyelinating Or Amyelinating Neuropathy Autosomal Recessive Congenital Hypomyelinating Neuropathy Congenital Amyelinating Neuropathy Congenital Hypomyelinating Neuropathy Autosomal Recessive Neuropathy, Congenital Hypomyelinating Or Amyelinating Severe Congenital Hypomyelination Hereditary Sensory Motor Neuropathy Charcot-Marie-Tooth Disease, Demyelinating, Autosomal Recessive Neuropathy, Hypomyelinating, Congenital, Type 1 Neuropathy, Motor And Sensory, Hereditary Congenital Hypomyelinating Neuropathy Hereditary Motor And Sensory Neuropathies Hereditary Sensorimotor Neuropathy Hmsn - [Hereditary Motor And Sensory Neuropathy] Hsmn - [Hereditary Sensory And Motor Neuropathy] Hereditary Motor And Sensory Neuropathy, Types I-Iv
Hypertrophic Neuropathy Of Dejerine-Sottas	Dejerine-Sottas Disease Dejerine-Sottas Syndrome Charcot-Marie-Tooth Disease Type 3 DSS Hereditary Motor And Sensory Neuropathy Type Iii Hmsn3 Dejerine-Sottas Neuropathy Hmsn Iii Charcot-Marie-Tooth Disease, Type 3 Cmt3 Dsn Hmsn 3 Hereditary Motor And Sensory Neuropathy Type 3 Hereditary Motor And Sensory Neuropathy 3 Hypertrophic Neuropathy Of Infancy Charcot-Marie-Tooth Disease Demyelinating Type 4f Charcot-Marie-Tooth Disease Type 4f Charcot-Marie-Tooth Neuropathy Type 4f Cmt4f Hereditary Motor And Sensory Neuropathy Iii Charcot-Marie-Tooth Disease, Demyelinating, Type 4f

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08996	NAB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	NAB1	MGD	MGI:107564
Bos taurus	NAB1	VGNC	VGNC:31857
Felis catus	NAB1	VGNC	VGNC:68408
Macaca mulatta	NAB1	VGNC	VGNC:99386
Canis familiaris	NAB1	VGNC	VGNC:43600
Rattus norvegicus	NAB1	RGD	RGD:70882
Others	NAB1	NCBI