NDUFB1 - NADH:ubiquinone oxidoreductase subunit B1 Gene

Also Known as MNLL; CI-MNLL; CI-SGDH

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4707

About NDUFB1

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,116,123-92,121,706 (from NCBI)

This gene has 7 transcripts (splice variants) and 198 orthologues. Ubiquitous expression in kidney (RPKM 82.0), colon (RPKM 69.9) and 25 other tissues.

Summary

Involved in mitochondrial respiratory chain complex I assembly. Located in mitochondrion and nuclear speck. Part of mitochondrial respiratory chain complex I. [provided by Alliance of Genome Resources, Apr 2022]

NDUFB1 Products (1)

mRNA	Protein	Name
NM_004545.4	NP_004536.3	NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	References	Source
involved in mitochondrial respiratory chain complex I assembly	IMP IMP: Inferred from mutant phenotype	27626371	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in mitochondrial inner membrane	IDA IDA: Inferred from direct assay	28844695	GOA
part of respiratory chain complex I	IDA IDA: Inferred from direct assay	12611891	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NDUFB1 Protein Structure

NADH_oxidored

0
58 a.a.

Protein Preferred Names	Protein Names
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1	NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa

NDUFB1 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P82759	NDUFB1 Antibody (YA2504)	WB, IHC-P	Human
HY-P82759A	NDUFB1 Antibody (YA2504)(PBS only)	WB, IHC-P	Human

Related Diseases

Diseases	Alias
Bacterial Gastritis
Mitochondrial Dna Depletion Syndrome 9	MTDPS9 Fatal Infantile Lactic Acidosis Lactic Acidosis, Fatal Infantile, Formerly Fatal Infantile Lactic Acidosis With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome 9 Encephalomyopathic Type With Methylmalonic Aciduria Mitochondrial Dna Depletion Syndrome, Type 9 Lactic Acidosis, Fatal Infantile
Leber Optic Atrophy And Dystonia	LDYT Marsden Syndrome Leber Hereditary Optic Neuropathy With Dystonia Leber Hereditary Optic Neuropathy And Dystonia Familial Dystonia With Visual Failure And Striatal Lucencies Dystonia, Familial, With Visual Failure And Striatal Lucencies Leber Optic Atrophy With Dystonia Dystonia Familial, With Visual Failure And Striatal Lucencies Lhon And Dystonia Leber'S Hereditary Optic Neuropathy With Dystonia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09144	NDUFB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NDUFB1	RGD	RGD:6487218
Macaca mulatta	NDUFB1	VGNC	VGNC:106440
Mus musculus	NDUFB1	MGD	MGI:3780865
Others	NDUFB1	NCBI