2. Gene
  3. NONO - non-POU domain containing octamer binding Gene

NONO - non-POU domain containing octamer binding Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as P54; NMT55; NRB54; MRXS34; P54NRB; PPP1R114

Gene ID: 4841 | Gene type: protein coding

About NONO

Cytogenetic location: Xq13.1 Genomic coordinates (GRCh38): X:71,283,635-71,301,168 (from NCBI)

This gene has 40 transcripts (splice variants), 217 orthologues, 7 paralogues and is associated with 62 phenotypes. Ubiquitous expression in ovary (RPKM 81.7), lymph node (RPKM 64.3) and 25 other tissues.

Summary

This gene encodes an RNA-binding protein which plays various roles in the nucleus, including transcriptional regulation and RNA splicing. A rearrangement between this gene and the transcription factor E3 gene has been observed in papillary renal cell carcinoma. Alternatively spliced transcript variants have been described. Pseudogenes exist on Chromosomes 2 and 16. [provided by RefSeq, Feb 2009]

NONO Products(4)

mRNA Protein Name
NM_001145408.2 NP_001138880.1 non-POU domain-containing octamer-binding protein isoform 1
NM_001145409.2 NP_001138881.1 non-POU domain-containing octamer-binding protein isoform 1
NM_001145410.2 NP_001138882.1 non-POU domain-containing octamer-binding protein isoform 2
NM_007363.5 NP_031389.3 non-POU domain-containing octamer-binding protein isoform 1

NONO Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (76 - 140)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (150 - 210)

NOPS

NOPS: NOPS (NUC059) domain (221 - 272)

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  • 471 a.a.
Protein Preferred Names Protein Names

non-POU domain-containing octamer-binding protein

54 kDa nuclear RNA- and DNA-binding protein

Related Diseases

Diseases Alias
Intellectual Developmental Disorder, X-Linked, Syndromic 34

MRXS34

Mental Retardation, X-Linked, Syndromic, Mircsof-Langouet Type

Mrxsml

Mental Retardation, X-Linked, Syndromic 34

Intellectual Developmental Disorder, X-Linked Syndromic 34

Mental Retardation, X-Linked, Syndromic, Type 34
Syndromic X-Linked Intellectual Disability 34

Macrocephaly-Intellectual Disability-Left Ventricular Non Compaction Syndrome

Mental Retardation, X-Linked, Syndromic 34

Mrxs34

Mrxsml

Syndromic X-Linked Mental Retardation Mircsof-Langouet Type
Renal Cell Carcinoma, Xp11-Associated

RCCX1

Mit Family Translocation Renal Cell Carcinoma

Renal Cell Carcinoma, Papillary, 1

Carcinoma Associated With Mitf/Tfe Translocation

Translocation Renal Cell Carcinoma

Renal Cell Carcinoma Xp11-Associated

Renal Cell Carcinoma Papillary 1

Carcinoma, Renal Cell, Xp11-Associated
Heart Disease

Heart Failure

Congenital Heart Disease

Heart Diseases

Congenital Heart Defects

Congenital Heart Defect

Heart Malformation

Congenital Anomaly Of Heart

Heart Defect

Heart-Congenital Defect

Congenital Heart Disorder

Heart Defects Congenital

Heart Defects, Congenital

Heart Defects

Heart Disease, Congenital

Disease, Heart, Congenital

Congestive Heart Failure
Small Intestine Neuroendocrine Neoplasm

Small Intestine Neuroendocrine Tumor

Neuroendocrine Tumor Of The Small Intestine

Net Of The Small Intestine

Neuroendocrine Neoplasm Of The Small Intestine

Neuroendocrine Tumor Of Small Bowel

Small Intestinal Neuroendocrine Neoplasm
Alveolar Soft Part Sarcoma

ASPS

Alveolar Soft-Part Sarcoma

Sarcoma, Alveolar Soft Part

Alveolar Soft Tissue Sarcoma

Sarcoma Alveolar Soft Part

Adult Alveolar Soft-Part Sarcoma

Childhood Alveolar Soft-Part Sarcoma
Perivascular Epithelioid Cell Tumor

Pecoma

Perivascular Epithelioid Cell Neoplasms

Neoplasm With Perivascular Epithelioid Cell Differentiation
Angelman Syndrome

AS

Happy Puppet Syndrome

Happy Puppet Syndrome, Formerly

Puppetlike Syndrome
Renal Cell Carcinoma, Papillary, 1

Papillary Renal Cell Carcinoma

Hereditary Papillary Renal Cell Carcinoma

Papillary Renal Cell Carcinoma, Sporadic

Papillary Renal Cell Adenocarcinoma

RCCP

RCCP1

Renal Cell Carcinoma, Papillary

Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

Chromophil Carcinoma Of Kidney

Papillary Kidney Carcinoma

Sporadic Papillary Renal Cell Carcinoma

Chromophil Renal Cell Carcinoma

Papillary Renal Carcinoma, Malignant -

Papillary Renal Cell Carcinoma, Bilateral -

Papillary Renal Cell Carcinoma, Familial -

Papillary Renal Cell Carcinoma, Multiple -

Papillary Renal Cell Carcinoma, Sporadic -

Renal Adenocarcinoma

Chromophil Rcc

Hprcc

Renal Cell Carcinoma Papillary

Chromophilic Renal Cell Carcinoma

Prcc

Carcinoma, Renal Cell, Papillary, Type 1

Type 1 Papillary Renal Cell Carcinoma

Renal Cell Carcinoma

Hereditary Papillary Renal Carcinoma
Dystonia

Dystonic Disease

Dystonic Disorder

Dystonia Disorders

Neuroleptic Dyskinesia
Left Ventricular Noncompaction

Noncompaction Cardiomyopathy

Left Ventricular Hypertrabeculation

Lvnc

Spongy Myocardium

Isolated Noncompaction Of The Ventricular Myocardium

Left Ventricular Myocardial Noncompaction Cardiomyopathy

Fetal Myocardium

Honeycomb Myocardium

Hypertrabeculation Syndrome

Left Ventricular Non-Compaction

Lvht

Non-Compaction Of The Left Ventricular Myocardium

Ventricular Noncompaction, Left

Non-Compaction Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-153918 (R)-SKBG-1 Inhibitor 98.03% Unkown
HY-RS09425 NONO Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta NONO VGNC VGNC:75367
Rattus norvegicus NONO RGD RGD:1549738
Mus musculus NONO MGD MGI:1855692
Bos taurus NONO VGNC VGNC:32163
Canis familiaris NONO VGNC VGNC:54178