NUCB1 - nucleobindin 1 Gene

Also Known as NUC; CALNUC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 4924

About NUCB1

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:48,900,312-48,923,372 (from NCBI)

This gene has 12 transcripts (splice variants), 191 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 89.1), fat (RPKM 86.3) and 25 other tissues.

Summary

This gene encodes a member of a small calcium-binding EF-hand protein family. The encoded protein is thought to have a key role in Golgi calcium homeostasis and CA(2+)-regulated signal transduction events. [provided by RefSeq, Jun 2010]

NUCB1 Products (1)

mRNA	Protein	Name
NM_006184.6	NP_006175.2	nucleobindin-1 precursor

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	24136289	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum-Golgi intermediate compartment	IDA IDA: Inferred from direct assay	15308636	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUCB1 Protein Structure

EF-hand_7

0
100
200
300
400
461 a.a.

Protein Preferred Names	Protein Names
nucleobindin-1

NUCB1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	NUCB1	Q02818	NUCB2	Homo sapiens	P80303	Anti Tag CoIP	33961781
Cross	NUCB1	Q02818	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Pull Down	24136289
Cross	NUCB1	Q02818	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Split-Luc	24136289
Cross	NUCB1	Q02818	Q99IB8-PRO_0000045603	Hepatitis C virus	Q99IB8-PRO_0000045603	Y2H	24136289

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Chromosome 16p11.2 Duplication Syndrome	Proximal 16p11.2 Microduplication Syndrome Proximal Dup(16)(P11.2) Proximal Trisomy 16p11.2 Autism, Susceptibility To, 14b Autism 14b
Spinal Ependymoma, Mycn-Amplified	Spinal Ependymoma, Mycn Spinal Cord Ependymoma, Mycn Amplified
Intellectual Developmental Disorder, Autosomal Dominant 46	MRD46 Mental Retardation, Autosomal Dominant 46 Autosomal Dominant Mental Retardation 46 Autosomal Dominant Intellectual Developmental Disorder 46 Mental Retardation, Autosomal Dominant, Type 46
External Ear Disease	Diseases Of External Ear Preauricular Cyst Preauricular Sinus And Fistula Preauricular Sinus Or Fistula
Otitis Externa	Swimmer'S Ear Infective Otitis Externa Acute Infective Otitis Externa
Erythema Infectiosum	Fifth Disease Slapped Cheek Syndrome Parvovirus B19 Infection
Retinitis Pigmentosa	RP Rod-Cone Dystrophy Autosomal Recessive Retinitis Pigmentosa Non-Syndromic Retinitis Pigmentosa Pericentral Pigmentary Retinopathy Pigmentary Retinopathy Tapetoretinal Degeneration Rcd Retinitis Pigmentosa Autosomal Recessive ARRP Retinitis Pigmentosa, Autosomal Recessive Retinitis Pigmentosa 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118319	MJN228		99.30%	Unkown
HY-RS09654	NUCB1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21674	Nucb1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28192	Nucb1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NUCB1	VGNC	VGNC:32318
Canis familiaris	NUCB1	VGNC	VGNC:53746
Rattus norvegicus	NUCB1	RGD	RGD:620030
Macaca mulatta	NUCB1	VGNC	VGNC:75548
Mus musculus	NUCB1	MGD	MGI:97388
Felis catus	NUCB1	VGNC	VGNC:68586