TRIM72 - tripartite motif containing 72 Gene

Also Known as MG53

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 493829

About TRIM72

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:31,214,119-31,231,537 (from NCBI)

This gene has 2 transcripts (splice variants), 104 orthologues and 80 paralogues. Biased expression in prostate (RPKM 2.0), esophagus (RPKM 0.3) and 1 other tissue.

Summary

Enables identical protein binding activity. Predicted to be involved in several processes, including cellular protein metabolic process; plasma membrane repair; and protein homooligomerization. Predicted to act upstream of or within negative regulation of Insulin Receptor signaling pathway; negative regulation of insulin-like growth factor receptor signaling pathway; and negative regulation of myotube differentiation. Predicted to be located in cytoplasmic vesicle membrane. Predicted to be active in cytoplasm and sarcolemma. [provided by Alliance of Genome Resources, Apr 2022]

TRIM72 Products (1)

mRNA Protein Name
NM_001008274.4 NP_001008275.2 tripartite motif-containing protein 72

TRIM72 Protein Structure

zf-C3HC4_4

zf-C3HC4_4: zinc finger of C3HC4-type, RING (14 - 56)

zf-B_box

zf-B_box: B-box zinc finger (84 - 121)

PRY

PRY: SPRY-associated domain (291 - 339)

SPRY

SPRY: SPRY domain (343 - 457)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 477 a.a.
Protein Preferred Names Protein Names

tripartite motif-containing protein 72

  • mitsugumin-53

TRIM72 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TRIM72 Q6ZMU5 ABI2 Homo sapiens Q9NYB9-2
Validated Y2H
32296183
Intra
TRIM72 Q6ZMU5 TCF12 Homo sapiens Q99081-3
Validated Y2H
32296183
Intra
TRIM72 Q6ZMU5 TCF12 Homo sapiens Q99081-3
Y2H Array
32296183
Intra
TRIM72 Q6ZMU5 TCF12 Homo sapiens Q99081-3
Y2H Prey Pooling
32296183
Intra
TRIM72 Q6ZMU5 PPP3CA Homo sapiens Q08209-2
Y2H Array
32296183
Intra
TRIM72 Q6ZMU5 PPP3CA Homo sapiens Q08209-2
Y2H Prey Pooling
32296183
Intra
TRIM72 Q6ZMU5 NMI Homo sapiens Q13287
Y2H Array
32296183
Intra
TRIM72 Q6ZMU5 MZT1 Homo sapiens Q08AG7
Y2H Prey Pooling
32296183
Intra
TRIM72 Q6ZMU5 MED21 Homo sapiens Q13503
Y2H Prey Pooling
32296183
Intra
TRIM72 Q6ZMU5 TCF12 Homo sapiens Q99081
Y2H Prey Pooling
25416956
Intra
TRIM72 Q6ZMU5 MZT1 Homo sapiens Q08AG7
Y2H Array
32296183
Intra
TRIM72 Q6ZMU5 C1orf216 Homo sapiens Q8TAB5
Validated Y2H
32296183
Intra
TRIM72 Q6ZMU5 TCF12 Homo sapiens Q99081
Y2H Array
25416956
Intra
TRIM72 Q6ZMU5 NMI Homo sapiens Q13287
Y2H Prey Pooling
32296183
Intra
TRIM72 Q6ZMU5 SMARCD1 Homo sapiens Q96GM5
Validated Y2H
32296183
Intra
TRIM72 Q6ZMU5 ZNF655 Homo sapiens Q8N720
Y2H Prey Pooling
32296183
Intra
TRIM72 Q6ZMU5 ZNF655 Homo sapiens Q8N720
Validated Y2H
32296183
Intra
TRIM72 Q6ZMU5 ZNF655 Homo sapiens Q8N720
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Miyoshi Muscular Dystrophy

  • Distal Myopathy

  • Distal Muscular Dystrophy

  • Miyoshi Myopathy

  • Distal Myopathies

  • Dystrophy, Muscular, Miyoshi

  • Myopathy, Distal

  • Distal Muscular Dystrophies
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b

  • Lgmd2b

  • Lgmd3

  • Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency

  • Limb-Girdle Muscular Dystrophy Type 3

  • Muscular Dystrophy, Limb-Girdle, Type 2b
Glycogen Storage Disease Vii

  • Glycogen Storage Disease Type Vii

  • Muscle Phosphofructokinase Deficiency

  • Tarui Disease

  • GSD7

  • Pfkm Deficiency

  • Gsd Vii

  • Glycogen Storage Disease, Type Vii

  • Glycogen Storage Disease Type 7

  • Phosphofructokinase Deficiency

  • Glycogenosis Type Vii

  • Phosphofructokinase Myopathy

  • Glycogenosis 7

  • Glycogen Storage Disease Due To Muscle Phosphofructokinase Deficiency

  • Gsd Due To Muscle Phosphofructokinase Deficiency

  • Gsd Type 7

  • Gsd Type Vii

  • Glycogenosis Due To Muscle Phosphofructokinase Deficiency

  • Glycogenosis Type 7

  • Glycogen Storage Disease 7

  • Gsd-Vii

  • Storage Disease, Glycogen, Type Vii
Autosomal Recessive Limb-Girdle Muscular Dystrophy

  • Muscular Dystrophy, Limb-Girdle, Autosomal Recessive
Limb-Girdle Muscular Dystrophy

  • Lgmd

  • Limb Girdle Muscular Dystrophy

  • Muscular Dystrophies, Limb-Girdle

  • Erb'S Muscular Dystrophy

  • Leyden-Mbius Muscular Dystrophy

  • Limb-Girdle Syndrome

  • Myopathic Limb-Girdle Syndrome

  • Limb Girdle

  • Muscular Dystrophy Limb-Girdle

  • Dystrophy, Muscular, Limb-Girdle

  • Lgmd - [Limb-Girdle Muscular Dystrophy]

  • Limb Girdle Muscle Dystrophy

  • Limb-Girdle Myopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS15071 TRIM72 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21211 Trim72 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27727 Trim72 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TRIM72 MGD MGI:3612190
Canis familiaris TRIM72 VGNC VGNC:47838
Rattus norvegicus TRIM72 RGD RGD:1562778
Macaca mulatta TRIM72 VGNC VGNC:79927
Bos taurus TRIM72 VGNC VGNC:58423
Felis catus TRIM72 VGNC VGNC:66554
Others TRIM72 NCBI