OVOL1 - ovo like transcriptional repressor 1 Gene

Also Known as HOVO1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5017

About OVOL1

Cytogenetic location: 11q13.1 Genomic coordinates (GRCh38): 11:65,787,063-65,797,214 (from NCBI)

This gene has 3 transcripts (splice variants), 120 orthologues and 29 paralogues. Biased expression in esophagus (RPKM 10.0), testis (RPKM 9.1) and 9 other tissues.

Summary

This gene encodes a putative zinc finger containing transcription factor that is highly similar to homologous protein in Drosophila and mouse. Based on known functions in these species, this protein is likely involved in hair formation and spermatogenesis in human as well. [provided by RefSeq, Aug 2011]

OVOL1 Products (1)

mRNA	Protein	Name
NM_004561.4	NP_004552.2	putative transcription factor Ovo-like 1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	28514442	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

OVOL1 Protein Structure

zf-H2C2_2

0
100
200
267 a.a.

Protein Preferred Names	Protein Names
putative transcription factor Ovo-like 1	ovo homolog-like 1

OVOL1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	OVOL1	O14753	LMNB2	Homo sapiens	Q03252	Validated Y2H	32296183
Intra	OVOL1	O14753	FAM90A1	Homo sapiens	Q86YD7	Validated Y2H	32296183
Intra	OVOL1	O14753	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	33961781
Intra	OVOL1	O14753	SUFU	Homo sapiens	Q9UMX1	Anti Tag CoIP	28514442

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Conjunctival Intraepithelial Neoplasm	Intraepithelial Neoplasia Of Conjunctiva Conjunctival Intraepithelial Neoplasia
Fetal Encasement Syndrome	Cocoon Syndrome COCOS Fetal Diseases
Popliteal Pterygium Syndrome	PPS Faciogenitopopliteal Syndrome Facio-Genito-Popliteal Syndrome Popliteal Web Syndrome Autosomal Dominant Popliteal Pterygium Syndrome Cleft Lip/Palate, Paramedian Mucous Cysts Of The Lower Lip, Popliteal Pterygium, Digital And Genital Anomalies Popliteal Pterygium Syndrome 1 Cleft Lip/Palate Paramedian Mucous Cysts Of The Lower Lip Popliteal Pterygium Digital And Genital Anomalies Popliteal Pterygium
Osteogenesis Imperfecta, Type Xii	Osteogenesis Imperfecta Type 12 OI12 Osteogenesis Imperfecta Type Xii Oi, Type Xii Osteogenesis Imperfecta 12 Oi Type Xii Oi-Xii Osteogenesis Imperfecta Sillence Type Iii

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09883	OVOL1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21007	Ovol1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27524	Ovol1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	OVOL1	VGNC	VGNC:75728
Felis catus	OVOL1	VGNC	VGNC:68665
Mus musculus	OVOL1	MGD	MGI:1330290
Canis familiaris	OVOL1	VGNC	VGNC:44196
Bos taurus	OVOL1	VGNC	VGNC:32505
Rattus norvegicus	OVOL1	RGD	RGD:1306956
Others	OVOL1	NCBI