DUOX2 - dual oxidase 2 Gene

Also Known as TDH6; LNOX2; THOX2; NOXEF2; P138-TOX

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 50506

About DUOX2

Cytogenetic location: 15q21.1 Genomic coordinates (GRCh38): 15:45,092,650-45,114,172 (from NCBI)

This gene has 5 transcripts (splice variants), 129 orthologues, 6 paralogues and is associated with 3 phenotypes. Biased expression in gall bladder (RPKM 216.4), thyroid (RPKM 55.7) and 3 other tissues.

Summary

The protein encoded by this gene is a glycoprotein and a member of the NADPH Oxidase family. The synthesis of thyroid hormone is catalyzed by a protein complex located at the apical membrane of thyroid follicular cells. This complex contains an iodide transporter, thyroperoxidase, and a peroxide generating system that includes this encoded protein and DUOX1. This protein is known as dual oxidase because it has both a peroxidase homology domain and a gp91phox domain. [provided by RefSeq, Jul 2008]

DUOX2 Products (2)

mRNA	Protein	Name
NM_001363711.2	NP_001350640.1	dual oxidase 2 isoform 2 precursor
NM_014080.5	NP_054799.4	dual oxidase 2 isoform 1 precursor

DUOX2 Protein Structure

An_peroxidase

EF-hand_7

Ferric_reduct

FAD_binding_8

NAD_binding_6

0
300
600
900
1200
1548 a.a.

Protein Preferred Names	Protein Names
dual oxidase 2	NADH/NADPH thyroid oxidase p138-tox

DUOX2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	DUOX2	Q9NRD8	DUOXA2	Homo sapiens	Q1HG44	Anti Tag CoIP	25761904
Intra	DUOX2	Q9NRD8	DUOXA2	Homo sapiens	Q1HG44	Anti Bait CoIP	25761904
Intra	DUOX2	Q9NRD8	DUOXA2	Homo sapiens	Q1HG44	Comig Non-Denat Gel	25761904

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Thyroid Dyshormonogenesis 6	TDH6 Genetic Defect In Thyroid Hormonogenesis 6 Thyroid Hormonogenesis, Genetic Defect In, 6 Hypothyroidism, Congenital, Due To Dyshormonogenesis, 6 Chdh6 Congenital Hypothyroidism Due To Dyshormonogenesis Type 6
Familial Thyroid Dyshormonogenesis	Thyroid Dyshormonogenesis Familial Dyshormonogenetic Goiter
Genetic Transient Congenital Hypothyroidism
Congenital Hypothyroidism	Cretinism Neonatal Hypothyroidism Ch Cht Congenital Myxedema Myxedema, Congenital Endemic Cretinism Congenital Iodine-Deficiency Syndrome Fetal Iodine Deficiency Syndrome Congenital Iodine-Deficiency Hypothyroidism Nos
Hypothyroidism	Thyroid Diseases Thyroid Disease Thyroid Deficiency Thyroid Insufficiency Dysfunction Thyroid Thyroid Dysfunction
Pendred Syndrome	Goiter-Deafness Syndrome Deafness With Goiter PDS Thyroid Dyshormonogenesis 2b Tdh2b Autosomal Recessive Sensorineural Hearing Impairment And Goiter Pendred'S Syndrome Thyroid Hormonogenesis, Genetic Defect In, 2b Hypothyroidism, Congenital, Due To Dyshormonogenesis, 2b Congenital Hypothyroidism Due To Dyshormonogenesis 2b Genetic Defect In Thyroid Hormonogenesis 2b Autosomal Recessive Sensorineural Hearing Impairment, Enlarged Vestibular Aqueduct, And Goiter Goiter-Hearing Loss Syndrome Goitre-Deafness Syndrome Goitre Deafness
Goiter	Goitre
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Colitis
Granulomatous Disease, Chronic, Autosomal Recessive, 4	Granulomatous Disease, Chronic, Autosomal Recessive, Cytochrome B-Negative Cyba Deficiency CGD4 Cgd Due To Deficiency Of The Alpha Subunit Of Cytochrome B Autosomal Recessive Chronic Granulomatous Disease Cytochrome B-Negative Cgd, Autosomal Recessive Cytochrome B-Negative Chronic Granulomatous Disease 4, Autosomal Recessive Autosomal Recessive Chronic Granulomatous Disease 4 Autosomal Recessive Cytochrome B-Negative Cgd Chronic Granulomatous Disease Due To Deficiency Of Cyba Cgd Due To Deficiency Of Alpha Subunit Of Cytochrome B Chronic Granulomatous Disease Autosomal Recessive Cytochrome B-Negative Granulomatous Disease, Chronic, Cytochrome-B-Negative, Autosomal Recessive
Phagocyte Bactericidal Dysfunction	Phagocytic Dysfunction
Inflammatory Bowel Disease	Inflammatory Bowel Diseases Bowel Disease, Inflammatory
Dyshormonogenic Goiter	Dyshormonogenic Goitre
Ileocolitis	Iieocolitis
Constipation
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Granulomatous Disease, Chronic, X-Linked	CGDX Chronic Granulomatous Disease, X-Linked X-Linked Chronic Granulomatous Disease Cgd Cytochrome B-Negative Granulomatous Disease, Chronic, X-Linked Cdgx X-Linked Chronic Cytochrome B-Negative Granulomatous Disease Chronic Granulomatous Disease Cytochrome B-Negative X-Linked Chronic Granulomatous Disease Cytochrome B-Positive X-Linked Granulomatous Disease, Chronic, X-Linked, Variant
Hypothyroidism, Thyroidal Or Athyroidal, With Spiky Hair And Cleft Palate	Bamforth-Lazarus Syndrome Bamforth Syndrome Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Hypothyroidism Cleft Palate Hypothyroidism, Athyroidal, With Spiky Hair And Cleft Palate Athyroidal Hypothyroidism-Spiky Hair-Cleft Palate Syndrome Hypothyroidism-Cleft Palate Syndrome BLS Athyroidal Hypothyroidism With Spiky Hair And Cleft Palate
Lung Disease	Lung Diseases Disorder Of Lung Abnormality Of The Lung
Thyroid Gland Disease	Abnormality Of The Thyroid Gland Thyroid Diseases
Ichthyosis, Congenital, Autosomal Recessive 3	Autosomal Recessive Congenital Ichthyosis 3 ARCI3 Lamellar Ichthyosis 5 Collodion Baby, Self-Healing Ichthyosis, Lamellar, 5, Formerly Li5, Formerly Li5 Self-Healing Collodion Baby Ichthyosis, Congenital, Autosomal Recessive, Type 3
Hypertension, Essential	Essential Hypertension Hypertension High Blood Pressure Hypertension, Essential, Susceptibility To Hypertensive Disease Primary Hypertension EHT Hypertension, Salt-Sensitive Essential, Susceptibility To Hyperpiesia Idiopathic Hypertension Hypertensive Disorder Hypertension, Essential, Susceptibility To, 3 Hypertension, Essential 3 Hypertension, Essential, Salt-Sensitive Hypertension, Essential, Susceptibility To, 6 Hypertension, Essential 6 Hypertension, Salt-Sensitive Essential Hypertension, Susceptibility To Hypertension, Essential, Susceptibility To, 4 Hypertension, Essential 4 Hypertension, Essential, Susceptibility To, 2 Hypertension, Essential 2 Hypertension, Essential, Susceptibility To, 1 Hypertension, Essential 1 Hypertension, Essential, Susceptibility To, 5 Hypertension, Essential 5 Htn Vascular Hypertensive Disorder Systemic Primary Arterial Hypertension Hbp - [High Blood Pressure] Systemic Arterial Hypertensive Disorder Elevated Blood Pressure Arterial Hypertension Nos Hypertension Nos Benign Hypertension Systemic Arterial Hypertension Systemic Hypertension Artery Htn Benign Htn Vascular Htn Vascular Hypertension Cholesterol Hypertension Cholesterol Htn Idiopathic Htn Malignant Hypertension Malignant Htn Raised Blood Pressure Cardiovascular Hypertension Primary Htn - [Hypertension] High Arterial Tension High Blood Pressure Disorder Ht - [Hypertension] Htn - [Hypertension] Hypertensive Vascular Disease Hypertensive Vascular Degeneration

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04045	DUOX2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20913	Duox2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22474	Duox1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27430	Duox2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	DUOX2	MGD	MGI:3036280
Rattus norvegicus	DUOX2	RGD	RGD:628761
Felis catus	DUOX2	VGNC	VGNC:61654
Bos taurus	DUOX2	VGNC	VGNC:28242
Canis familiaris	DUOX2	VGNC	VGNC:40121
Macaca mulatta	DUOX2	VGNC	VGNC:71833
Others	DUOX2	NCBI