AADAT - aminoadipate aminotransferase Gene

Also Known as KAT2; KATII; KYAT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51166

About AADAT

Cytogenetic location: 4q33 Genomic coordinates (GRCh38): 4:170,060,222-170,094,292 (from NCBI)

This gene has 8 transcripts (splice variants), 230 orthologues and 7 paralogues. Broad expression in liver (RPKM 11.4), prostate (RPKM 6.3) and 19 other tissues.

Summary

This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The Other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

AADAT Products (4)

mRNA Protein Name
NM_001286682.2 NP_001273611.1 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform a
NM_001286683.1 NP_001273612.1 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
NM_016228.4 NP_057312.1 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b
NM_182662.2 NP_872603.1 kynurenine/alpha-aminoadipate aminotransferase, mitochondrial isoform b

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables 2-aminoadipate transaminase activity IDA
IDA: Inferred from direct assay
18620547 GOA
enables glycine:2-oxoglutarate aminotransferase activity IDA
IDA: Inferred from direct assay
18620547 GOA
enables kynurenine-glyoxylate transaminase activity IDA
IDA: Inferred from direct assay
18620547 GOA
enables kynurenine-oxoglutarate transaminase activity IDA
IDA: Inferred from direct assay
18620547 GOA
enables methionine-glyoxylate transaminase activity IDA
IDA: Inferred from direct assay
18620547 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
18620547 GOA
Biological Process GO Annotation Evidence References Source
involved in 2-oxoglutarate metabolic process IDA
IDA: Inferred from direct assay
18620547 GOA
involved in glutamate metabolic process IDA
IDA: Inferred from direct assay
18620547 GOA
involved in kynurenine metabolic process IDA
IDA: Inferred from direct assay
18620547 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AADAT Protein Structure

Aminotran_1_2

Aminotran_1_2: Aminotransferase class I and II (59 - 415)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 425 a.a.
Protein Preferred Names Protein Names

kynurenine/alpha-aminoadipate aminotransferase, mitochondrial

  • 2-aminoadipate aminotransferase

Recombinant AADAT Proteins

Cat. No. Product Name Accession Purity
HY-P79300 AADAT/alpha-Aminoadipate Aminotransferase Protein, Human (His-SUMO) Q8N5Z0-1 (P30-L425) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Hydroxykynureninuria

  • Xanthurenic Aciduria

  • Kynureninase Deficiency

  • Kynureninase Deficiency, Partial

  • HYXKY

  • Partial Kynureninase Deficiency
Detrusor Sphincter Dyssynergia

  • Detrusor And Sphincter Dyssynergia
Huntington Disease

  • Huntington'S Disease

  • Huntington Chorea

  • Huntington'S Chorea

  • HD

  • Huntington Chronic Progressive Hereditary Chorea

  • Juvenile Huntington Disease

  • Chronic Progressive Chorea

  • Chronic Progressive Hereditary Chorea

  • Hc - [Huntington Chorea]

  • Hereditary Chorea

  • Progressive Hereditary Chorea
Schizophrenia

  • SCZD

  • Schizophrenia With Or Without An Affective Disorder

  • Schizophrenia 12

  • Schizophrenia, Susceptibility To

  • Schizophrenia-1

  • Dementia Praecox

  • Schizophrenia 1
Autism Spectrum Disorder

  • Asd

  • Autism Spectrum Disorders

  • Autistic Continuum

  • Pervasive Developmental Disorder

  • Pervasive Development Disorder

  • Autistic Behavior

  • Autistic Disorder

  • Autistic

  • Autistic Disorder Of Childhood Onset

  • Infantile Autism

  • Childhood Autism

  • Kanner Syndrome

  • Pervasive Developmental Delay Nos

  • Pervasive Developmental Disorder, Not Otherwise Specified
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS00018 AADAT Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19976 Aadat Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26479 Aadat Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus AADAT RGD RGD:2948
Mus musculus AADAT MGD MGI:1345167
Canis familiaris AADAT VGNC VGNC:37407
Bos taurus AADAT VGNC VGNC:25440
Felis catus AADAT VGNC VGNC:59449
Macaca mulatta AADAT VGNC VGNC:69454
Others AADAT NCBI