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TRPV2 - transient receptor potential cation channel subfamily V member 2 Gene

Also Known as VRL; VRL1; VRL-1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 51393

About TRPV2

Cytogenetic location: 17p11.2 Genomic coordinates (GRCh38): 17:16,415,571-16,437,003 (from NCBI)

This gene has 9 transcripts (splice variants), 263 orthologues and 5 paralogues. Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues.

Summary

This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in Other tissues the channel may be activated by stimuli Other than heat. [provided by RefSeq, Jul 2008]

TRPV2 Products (1)

mRNA	Protein	Name
NM_016113.5	NP_057197.2	transient receptor potential cation channel subfamily V member 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables monoatomic cation channel activity	IDA IDA: Inferred from direct assay	10201375	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	34158856	GOA

Biological Process GO Annotation	Evidence	References	Source
acts upstream of or within response to temperature stimulus	IDA IDA: Inferred from direct assay	10201375	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in plasma membrane	IDA IDA: Inferred from direct assay	10201375	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPV2 Protein Structure

Ank_2

Ion_trans

0
200
400
600
764 a.a.

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily V member 2	OTRPC2

TRPV2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89618	VRL-1 Antibody (YA8962)	WB, ICC/IF, IF-Tissue, IP, ELISA	human

Related Diseases

Diseases	Alias
Mutilating Palmoplantar Keratoderma With Periorificial Keratotic Plaques	Olmsted Syndrome Mutilating Palmoplantar Hyperkeratosis With Periorificial Keratotic Plaques Palmoplantar And Periorificial Keratoderma Olms
Scapuloperoneal Spinal Muscular Atrophy	SPSMA Amyotrophy, Neurogenic Scapuloperoneal, New England Type Neurogenic Scapuloperoneal Amyotrophy, New England Type Scapuloperoneal Neuronopathy Spinal Muscular Atrophy, Scapuloperoneal Amyotrophy Neurogenic Scapuloperoneal New England Type Muscular Atrophy, Spinal Scapuloperoneal Form Of Spinal Muscular Atrophy
Brachyolmia	Brachyrachia
Dentin Sensitivity	Sensitive Dentin
Dehydrated Hereditary Stomatocytosis 1 With Or Without Pseudohyperkalemia And/Or Perinatal Edema	Dehydrated Hereditary Stomatocytosis Hereditary Xerocytosis Xerocytosis, Hereditary Pshk1 Pseudohyperkalemia Edinburgh Dehydrated Hereditary Stomatocytosis With Or Without Pseudohyperkalemia And/Or Perinatal Edema DHS1 Dhs Hereditary Desiccytosis Dehydrated Hereditary Stomatocytosis 1 Desiccytosis, Hereditary Pseudohyperkalemia, Familial, 1, Due To Red Cell Leak Pseudohyperkalemia Familial 1, Due To Red Cell Leak Desiccytosis Hereditary Xerocytosis Hereditary Familial Pseudohyperkalemia 1 Due To Red Cell Leak Stomatocytosis, Dehydrated, Hereditary, With/Without Pseudohyperkalemia And/Or Perinatal Edema Xerocytosis
Lennox-Gastaut Syndrome	Lennox Syndrome Encephalopathy Of Childhood Epileptic Encephalopathy Lennox-Gastaut Type Childhood Epileptic Encephalopathy With Diffuse Slow Spikes And Waves Lgs
Dravet Syndrome	Severe Myoclonic Epilepsy Of Infancy Severe Myoclonic Epilepsy In Infancy Smei Epileptic Encephalopathy, Early Infantile, 6 DRVT Developmental And Epileptic Encephalopathy 6a Dee6a Eiee6 Developmental And Epileptic Encephalopathy, 6 Dee6 Developmental And Epileptic Encephalopathy 6 Early Infantile Epileptic Encephalopathy 6 Myoclonic Epilepsy, Severe, Of Infancy Sme Severe Myoclonus Epilepsy Of Infancy Borderline Smei Smeb Smeb-M Smeb-O Smeb-Sw Smei-Borderland Smei-Borderland More Than One Feature Smei-Borderland-Myoclonic Seizures Smei-Borderland-Spike Wave Intractable Childhood Epilepsy With Generalized Tonic-Clonic Seizures ICEGTC Infantile Severe Myoclonic Epilepsy Epilepsy, Intractable Childhood, With Generalized Tonic-Clonic Seizures
Migraine With Or Without Aura 1	Migraine Migraine With Or Without Aura, Susceptibility To, 1 Migraine Disorder Migraine Variant Migraines Migraine Disorders Mgr1 Mgau Ma Migraine With Or Without Aura Classic Migraine Common Migraine Disorder, Migraine Headache Migraine Headache Migrainous Migraine Headache Migraine Syndrome Headache Including Migraine Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-B0545	Probenecid	Agonist	99.94%	Yes

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-132222	SET2	Antagonist	99.78%	Unkown
HY-157131	TRPV2-selective blocker 1	Inhibitor	99.84%	Unkown
HY-182896	HKC54	Antagonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TRPV2	MGD	MGI:1341836
Rattus norvegicus	TRPV2	RGD	RGD:3965
Canis familiaris	TRPV2	VGNC	VGNC:47883
Macaca mulatta	TRPV2	VGNC	VGNC:79111
Felis catus	TRPV2	VGNC	VGNC:66596
Bos taurus	TRPV2	VGNC	VGNC:36398
Others	TRPV2	NCBI