SET2
Based on 2 publication(s) in Google Scholar
SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases.
For research use only. We do not sell to patients.
- Purity: 99.78%
- CAS No.: 2313525-20-9
- Formula: C17H21F3N4O2S
- Molecular Weight:402.43
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Storage:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Bioactive Compound Library Max
HY-L181
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Bioactive Compound Library
HY-L001
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Membrane Transporter/Ion Channel Compound Library
HY-L011
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Neuronal Signaling Compound Library
HY-L013
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Anti-Cancer Compound Library
HY-L025
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Mechanoreceptors Compound Library
HY-L095
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Anti-Prostate Cancer Compound Library
HY-L124
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Pain-Related Compound Library
HY-L139
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Highly Selective Inhibitors Library
HY-L158
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Ion Channel Compound Library
HY-L166
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MCE Bioactive Compound Library
HY-L001V
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High-Throughput Bioactive Compound Library
HY-L205
Publications Citing Use of MedChemExpress (MCE) SET2
More
Biological Activity
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TRPV2 0.46 μM (IC50) |
SET2 (20 μM; 24 h) abrogates the migration of PC-3M cells expressing TRPV2[1].
SET2 (20 μM; 24 h) inhibits 2-APB-evoked current in HEK293T cells transiently co-transfected with TRPV2 and LPAR1[1].
SET2 (20 μM; 24 h) inhibits the increase of (0.1 μM; 3 min) LPA-induced cytoplasmic calcium and LPA-induced migration in PC-3M cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:PC-3M prostate cancer cells
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Concentration:0, 5 μM, 10 μM, and 20 μM
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Incubation Time:24 hr and 48 hr
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Result:Inhibited cell migration of PC-3M cells, without inhibiting cell viability at 48 hours.
Chemical Information
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CAS No. 2313525-20-9
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Appearance Solid
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Molecular Weight 402.43
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Formula C17H21F3N4O2S
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Color White to off-white
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SMILES
O=C(CCSC1=NC(C(F)(F)F)=CC(N(CCC)C)=N1)NCC2=CC=CO2
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (2)
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Journal Impact Factor
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Most Recent
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Cell Death Dis
Pictilisib and nutrient stress synergize to induce methuosis via PI(4,5)P2-dependent macropinocytic dysregulation in cancer cells. [Abstract]2026 Jun 16. PMID: 42303628 -
J Med Chem
A Novel Compound 3a-M1, from Metabolites of Sinomenine Derivative 3a, Exerts Potent Anti-Aplastic Anemia Activity via IP3R/ORAI-Mediated CTL Ferroptosis. [Abstract]2025 Apr 17. PMID: 40243551
Solvent & Solubility
DMSO : 100 mg/mL (248.49 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (271 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.4849 mL | 12.4245 mL | 24.8490 mL | 62.1226 mL |
| 5 mM | 0.4970 mL | 2.4849 mL | 4.9698 mL | 12.4245 mL | |
| 10 mM | 0.2485 mL | 1.2425 mL | 2.4849 mL | 6.2123 mL | |
| 15 mM | 0.1657 mL | 0.8283 mL | 1.6566 mL | 4.1415 mL | |
| 20 mM | 0.1242 mL | 0.6212 mL | 1.2425 mL | 3.1061 mL | |
| 25 mM | 0.0994 mL | 0.4970 mL | 0.9940 mL | 2.4849 mL | |
| 30 mM | 0.0828 mL | 0.4142 mL | 0.8283 mL | 2.0708 mL | |
| 40 mM | 0.0621 mL | 0.3106 mL | 0.6212 mL | 1.5531 mL | |
| 50 mM | 0.0497 mL | 0.2485 mL | 0.4970 mL | 1.2425 mL | |
| 60 mM | 0.0414 mL | 0.2071 mL | 0.4142 mL | 1.0354 mL | |
| 80 mM | 0.0311 mL | 0.1553 mL | 0.3106 mL | 0.7765 mL | |
| 100 mM | 0.0248 mL | 0.1242 mL | 0.2485 mL | 0.6212 mL |
SET2 Related Classifications
HY-132222 Related Classifications
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