PLTP - phospholipid transfer protein Gene

Also Known as BPIFE; HDLCQ9

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5360

About PLTP

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:45,898,620-45,912,155 (from NCBI)

This gene has 5 transcripts (splice variants), 200 orthologues, 12 paralogues and is associated with 1 phenotype. Broad expression in placenta (RPKM 205.6), gall bladder (RPKM 89.3) and 21 other tissues.

Summary

The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers Phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in Cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

PLTP Products (4)

mRNA	Protein	Name
NM_001242920.2	NP_001229849.1	phospholipid transfer protein isoform c precursor
NM_001242921.1	NP_001229850.1	phospholipid transfer protein isoform d
NM_006227.4	NP_006218.1	phospholipid transfer protein isoform a precursor
NM_182676.3	NP_872617.1	phospholipid transfer protein isoform b precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables ceramide binding	IDA IDA: Inferred from direct assay	9132017	GOA
enables cerebroside transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables diacylglyceride transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables diacylglycerol binding	IDA IDA: Inferred from direct assay	9132017	GOA
enables high-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	29883800	GOA
enables low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	29883800	GOA
enables phosphatidic acid binding	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidic acid transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidylcholine binding	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidylcholine transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidylethanolamine binding	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidylethanolamine transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidylglycerol binding	IDA IDA: Inferred from direct assay	9132017	GOA
enables phosphatidylglycerol transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables phospholipid transfer activity	IDA IDA: Inferred from direct assay	7654777	GOA
enables phospholipid transfer activity	IMP IMP: Inferred from mutant phenotype	21515415	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32814053	GOA
enables sphingomyelin transfer activity	IDA IDA: Inferred from direct assay	9132017	GOA
enables very-low-density lipoprotein particle binding	IDA IDA: Inferred from direct assay	29883800	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in ceramide transport	IDA IDA: Inferred from direct assay	9132017	GOA
involved in glycolipid transport	IDA IDA: Inferred from direct assay	9132017	GOA
involved in high-density lipoprotein particle remodeling	IDA IDA: Inferred from direct assay	9132017	GOA
involved in lipid transport	IDA IDA: Inferred from direct assay	9132017	GOA
involved in phospholipid transport	IDA IDA: Inferred from direct assay	9132017	GOA
involved in positive regulation of cholesterol efflux	IDA IDA: Inferred from direct assay	24369175	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in extracellular region	IDA IDA: Inferred from direct assay	19321130	GOA
part of high-density lipoprotein particle	IDA IDA: Inferred from direct assay	9132017	GOA
located in nucleus	IDA IDA: Inferred from direct assay	19321130	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PLTP Protein Structure

LBP_BPI_CETP

LBP_BPI_CETP_C

0
100
200
300
400
493 a.a.

Protein Preferred Names	Protein Names
phospholipid transfer protein	BPI fold containing family E

Recombinant PLTP Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74625	PLTP Protein, Human (HEK293, His)	P55058-1 (E18-V493)	≥ 80%, as determined by reducing SDS-PAGE.

PLTP Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83009	PLTP Antibody (YA2754)	WB	Human, Rat

Related Diseases

Diseases	Alias
Hyperalphalipoproteinemia 1	Hyperalphalipoproteinemia HALP1 Cetp Deficiency Cholesterol-Ester Transfer Protein Deficiency Familial Hyperalphalipoproteinemia Cholesteryl Ester Transfer Protein Deficiency Cept Deficiency Cholesterol Ester Transfer Protein Deficiency
Hypoalphalipoproteinemia
Tangier Disease	Analphalipoproteinemia High Density Lipoprotein Deficiency, Tangier Type TGD High Density Lipoprotein Deficiency, Type 1 Hdldt1 Familial High Density Lipoprotein Deficiency A-Alphalipoprotein Neuropathy Alpha High Density Lipoprotein Deficiency Disease Cholesterol Thesaurismosis Familial High Density Lipoprotein Deficiency Disease Hdl Lipoprotein Deficiency Disease Tangier Disease Neuropathy Familial Alpha-Lipoprotein Deficiency Familial High-Density Lipoprotein Deficiency 1 Primary Hypoalphalipoproteinemia 1 Analphalipo-Proteinemia Familial Hypoalphalipo-Proteinemia Familial Hypoalphalipoproteinemia Lipoprotein Deficiency Disease, Hdl, Familial Tangier Hereditary Neuropathy Atp-Binding Cassette Transporter A1 Deficiency Hdld1 High Density Lipoprotein Deficiency 1 Tangier Disease, Variant Hypoalphalipoproteinemia, Familial Familial Hdl Deficiency
Type 2 Diabetes Mellitus	Insulin Resistance NIDDM Type 2 Diabetes Diabetes Mellitus, Non-Insulin-Dependent T2D Noninsulin-Dependent Diabetes Mellitus Diabetes Mellitus, Type Ii Maturity-Onset Diabetes Insulin Resistance, Severe, Digenic Diabetes Mellitus, Type 2 Diabetes Mellitus, Noninsulin-Dependent Diabetes Mellitus, Noninsulin-Dependent, Association With Diabetes Mellitus, Noninsulin-Dependent, Late Onset Hypertension, Insulin Resistance-Related, Susceptibility To Insulin Resistance, Susceptibility To Non-Insulin-Dependent Diabetes Mellitus Type Ii Diabetes Mellitus Adult-Onset Diabetes Mellitus Maturity-Onset Diabetes Mellitus Diabetes Mellitus Type 2 Type Ii Diabetes Type 2 Diabetes Mellitus, Susceptibility To Diabetes, Type 2 Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To Diabetes Mellitus, Type 2, Susceptibility To Diabetes Mellitus, Noninsulin-Dependent, 2 Diabetes Mellitus, Type Ii, Susceptibility To Hypertension, Insulin Resistance-Related Adult-Onset Diabetes Aodm Diabetes Mellitus, Adult-Onset Diabetes Mellitus Type Ii Diabetes Mellitus Type 2, Susceptibility To Diabetes, Type Ii, Susceptibility To Diabetes Type 2 Diabetes Mellitus Adult Onset Diabetes Maturity Onset Diabetes Nonketotic Diabetes Non-Insulin Dependent Diabetes Mellitus T2dm - [Type 2 Diabetes Mellitus] Niddm - [Non Insulin Dependent Diabetes Mellitus] Dm2 Dm Type Ii Diabetic Type 2 Insulin Requiring Type 2 Diabetes Noninsulin Dependent Diabetes Non-Insulin-Dependent Diabetes Mellitus Without Complications Diabetes Due To Insulin Secretory Defect Diabetes Mellitus Due To Insulin Secretory Defect Non-Insulin-Dependent Diabetes Of The Young Senile Diabetes Nonketotic Hyperglycaemia Stable Diabetes
Familial Hyperlipidemia	Familial Hyperlipoproteinemia Hyperlipidaemia Hyperlipoproteinemias Hyperlipidemia Hyperlipemia Hyperlipidemias
Lipid Metabolism Disorder	Dyslipidemia Disorder Of Fatty Acid Metabolism Lipid Metabolism Disorders Fatty Acid Metabolism Disorder Disorder Of Lipid Metabolism Abnormality Of Lipid Metabolism Lipid Metabolism, Inborn Errors Dyslipidemias Disorders Of Lipid Metabolism Congenital Disorders Of Lipid Metabolism Inherited Disorders Of Lipid Metabolism
Hypoalphalipoproteinemia, Primary, 1	Familial Hdl Deficiency Fha High Density Lipoprotein Deficiency Familial Hypoalphalipoproteinemia Hypoalphalipoproteinemia, Familial Hdld Fhd Hdl Deficiency, Type 2 Primary Hypoalphalipoproteinemia 1 Hdl Cholesterol, Low Serum Hdlc Hdl Deficiency, Familial, 1 Hypoalphalipoproteinemia, Primary Low Serum Hdl Cholesterol Primary Hypoalphalipoproteinemia FHA1 Hdld2 High Density Lipoprotein Deficiency 2 Hypoalphalipoproteinemias Apolipoprotein A-I Deficiency
Peripheral Vascular Disease	Peripheral Arterial Disease Arterial Occlusive Disease Arterial Occlusive Diseases Pad Peripheral Vascular Diseases Peripheral Occlusive Disease Peripheral Arterial Diseases Helicobacter Infections
Atherosclerosis Susceptibility	Atherosclerosis Atherosclerosis, Susceptibility To ATHS Atherogenic Lipoprotein Phenotype Alp Arteriosclerosis
Ceroid Lipofuscinosis, Neuronal, 6a	Neuronal Ceroid Lipofuscinosis 6 CLN6 Vlincl Cln6 Disease Ceroid Lipofuscinosis, Neuronal, 6 Late-Infantile Neuronal Ceroid Lipofuscinosis CLN6A Neuronal Ceroid Lipofuscinosis, Late Infantile, Variant Neuronal Ceroid Lipofuscinosis 6a Neuronal Ceroid Lipofuscinosis 6 Variable Age Of Onset Cln6 Disease, Adult Kufs Type A Cln6 Disease, Late Infantile Neuronal Ceroid Lipofuscinosis, Gypsy/Indian Early Juvenile Variant Ceroid Lipofuscinosis Neuronal 6 Cln6-Related Neuronal Ceroid Lipofuscinosis Late Infantile Neuronal Ceroid Lipofuscinosis Jansky-Bielschowsky Disease Lincl Late Infantile Ncl Neuronal Ceroid Lipofuscinosis 6 With Variable Age At Onset Variant Late-Onset Infantile Neuronal Ceroid Lipofuscinosis Ceroid Lipofuscinosis, Neuronal, Late Infantile, Variant Lipofuscinosis, Ceroid, Neuronal, Type 6 Ceroid Lipofuscinosis, Neuronal, 5
Hypolipoproteinemia	Hypolipoproteinaemia Lipoprotein Deficiencies Lipoprotein Disorder Hypolipoproteinemias Lipoprotein Lipoprotein Deficiency Hypolipidaemia Lipoprotein Deficiency Disorder High-Density Lipoid Deficiency High-Density Lipoprotein Deficiency Dyslipidaemia, Depressed Hdl Cholesterol
Diabetes Mellitus	Diabetes
Cardiovascular System Disease	Abnormality Of The Cardiovascular System Cardiovascular Disease Disease Of Subdivision Of Hemolymphoid System Disorder Of Cardiovascular System Cardiovascular Diseases
Hyperlipidemia, Familial Combined, 3	Familial Combined Hyperlipidemia Combined Hyperlipidemia, Familial Mixed Hyperlipidaemia FCHL3 Hyperlipidemia, Familial Combined Familial Multiple Lipoprotein-Type Hyperlipidemia Hyperbetalipoproteinemia With Prebetalipoproteinemia Type Iib Hyperlipoproteinemia Hyperlipidemia Familial Combined Hyperlipoproteinemia Type Iib Mixed Hyperlipemia Hyperlipidaemia, Group C Familial Hypercholesterolaemia With Hyperlipaemia Familial Hyperbetalipoproteinaemia And Hyperprebetalipoproteinaemia Hyperbetalipoproteinaemia With Prebetalipoproteinaemia Hypercholesterolaemia With Endogenous Hyperglyceridaemia Prebetalipoproteinemia Hyperbetalipoproteinaemia Remnant Hyperlipoproteinemia
Lipoprotein Quantitative Trait Locus	Coronary Artery Disease Coronary Artery Anomaly Coronary Artery Disease, Susceptibility To Myocardial Ischemia Congenital Anomaly Of Coronary Artery Coronary Arteriosclerosis Coronary Disease Coronary Heart Disease Coronary Artery Disorder LPAQTL Lpa Deficiency, Congenital Coronary Artery Abnormality Coronary Artery Anomaly, Congenital Chd Coronary Syndrome Congenital Malformations Of Coronary Vessels Malformation Of Coronary Vessels Congenital Coronary Artery Anomaly Congenital Coronary Artery Deformity Congenital Coronary Artery Disorder Abnormal Coronary Artery Congenital Coronary Artery Malposition Congenital Coronary Disease Congenital Anomaly Of Coronary Arteries
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis
Alzheimer Disease, Familial, 1	Alzheimer Disease Alzheimer'S Disease Presenile And Senile Dementia AD1 Alzheimer Disease, Susceptibility To Alzheimer Disease, Late-Onset, Susceptibility To Alzheimer Disease 1, Familial AD Familial Alzheimer Disease Alzheimer Disease, Late-Onset Alzheimers Dementia Alzheimer Dementia Alzheimer Sclerosis Alzheimer Syndrome Alzheimer-Type Dementia Dat Primary Senile Degenerative Dementia Sdat Alzheimer Disease 1 Autosomal Dominant Alzheimer Disease Early-Onset Alzheimer Disease With Cerebral Amyloid Angiopathy Late Onset Alzheimer Disease Alzheimers Disease Alzheimer Disease, Early-Onset, With Cerebral Amyloid Angiopathy Late-Onset Alzheimers Disease Alzheimer'S Disease Pathway Kegg Dementia Due To Alzheimer'S Disease Alzheimer Disease Type 1 Alzheimers

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10744	PLTP Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-179364	PLTP-IN-1		/	Unkown
HY-RS17817	Pltp Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24286	Pltp Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	PLTP	MGD	MGI:103151
Felis catus	PLTP	VGNC	VGNC:81150
Canis familiaris	PLTP	VGNC	VGNC:44714
Bos taurus	PLTP	VGNC	VGNC:33055
Rattus norvegicus	PLTP	RGD	RGD:1306695
Macaca mulatta	PLTP	VGNC	VGNC:76182
Others	PLTP	NCBI