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PLTP Protein, Human (HEK293, His)

Cat. No.: HY-P74625
COA Handling Instructions

PLTP proteins are centrally involved in lipid metabolism, mediating the transfer of phospholipids and free cholesterol between lipoproteins and HDL. This includes the exchange of various molecules such as diacylglycerol, sphingomyelin, and phosphatidylcholine. PLTP Protein, Human (HEK293, His) is the recombinant human-derived PLTP protein, expressed by HEK293 , with C-His labeled tag. The total length of PLTP Protein, Human (HEK293, His) is 476 a.a., with molecular weight of 70-80 kDa.

For research use only. We do not sell to patients.

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  • Biological Activity

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Description

PLTP proteins are centrally involved in lipid metabolism, mediating the transfer of phospholipids and free cholesterol between lipoproteins and HDL. This includes the exchange of various molecules such as diacylglycerol, sphingomyelin, and phosphatidylcholine. PLTP Protein, Human (HEK293, His) is the recombinant human-derived PLTP protein, expressed by HEK293 , with C-His labeled tag. The total length of PLTP Protein, Human (HEK293, His) is 476 a.a., with molecular weight of 70-80 kDa.

Background

PLTP Protein assumes a central role in lipid metabolism by mediating the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low-density lipoproteins or LDL and very low-density lipoproteins or VLDL) into high-density lipoproteins (HDL), as well as facilitating the exchange of phospholipids among triglyceride-rich lipoproteins. This extensive lipid transfer encompasses various molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside, and phosphatidyl ethanolamine. PLTP further plays a crucial role in remodeling HDL, influencing its size and composition. Additionally, the protein is a key player in the uptake of cholesterol from peripheral cells and tissues, facilitating its transport to the liver for degradation and excretion. Notably, two distinct forms of PLTP exist in plasma: an active form capable of transferring phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form lacking this capability, contributing to the nuanced regulation of lipid homeostasis.

Species

Human

Source

HEK293

Tag

C-His

Accession

P55058 (E18-V493)

Gene ID
Molecular Construction
N-term
PLTP (E18-V493)
Accession # P55058
His
C-term
Synonyms
Phospholipid transfer protein; Lipid transfer protein II; PLTP
Molecular Weight

70-80 kDa

Purity

Greater than 80% as determined by reducing SDS-PAGE.

Appearance

Solution

Formulation

Supplied as a 0.2 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

N/A.

Storage & Stability

Stored at -80°C for 1 year. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.

Shipping

Shipping with dry ice.

Documentation

PLTP Protein, Human (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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PLTP Protein, Human (HEK293, His)
Cat. No.:
HY-P74625
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