PLTP Protein, Human (HEK293, His)

PLTP Protein assumes a central role in lipid metabolism by mediating the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low-density lipoproteins or LDL and very low-density lipoproteins or VLDL) into high-density lipoproteins (HDL), as well as facilitating the exchange of phospholipids among triglyceride-rich lipoproteins. This extensive lipid transfer encompasses various molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside, and phosphatidyl ethanolamine. PLTP further plays a crucial role in remodeling HDL, influencing its size and composition. Additionally, the protein is a key player in the uptake of cholesterol from peripheral cells and tissues, facilitating its transport to the liver for degradation and excretion. Notably, two distinct forms of PLTP exist in plasma: an active form capable of transferring phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form lacking this capability, contributing to the nuanced regulation of lipid homeostasis.