PLTP Antibody (YA2754)
(Synonyms: BPIFE; HDLCQ9; OD107; Pltp)PLTP Antibody (YA2754) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLTP.
-
Host:
Rabbit
-
Isotype:
IgG
-
Application:
WB
-
Reactivity :
Human, Rat
-
Formulation:
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Conjugation:
Non-conjugated
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
Applications
| Application |
WB
WB: Western Blot
|
|---|---|
| Dilution Ratio | 1:500-1:1000 |
Product Details
PLTP Antibody (YA2754) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PLTP.
-
Host Rabbit
-
Clonality Recombinant,Monoclonal
-
Species ReactivityHuman, Rat
-
Observed Molecular WeightObserved band size: 80 kDa
Note: Due to possible protein modifications or aggregation, the molecular weight should be confirmed by actual measurement, and the predicted value is for reference only.
-
Calculated Molecular Weight Predicted band size: 55 kDa
A synthesized peptide derived from human PLTP aa250-270.
Endogenous
Affinity Purified
Non-conjugated
Unmodified
IgG
Product Properties
-
Appearance
Solution
-
Formulation
Supplied in rabbit IgG in phosphate buffered saline , pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage & Stability
Stored at -20°C for 1 year. Avoid repeated freeze / thaw cycles.
-
Shipping
Shipping with blue ice.
Background
-
Function
PLTP mediates the transfer of phospholipids and free cholesterol from triglyceride-rich lipoproteins (low density lipoproteins or LDL and very low density lipoproteins or VLDL) into high-density lipoproteins (HDL) as well as the exchange of phospholipids between triglyceride-rich lipoproteins themselves. Facilitates the transfer of a spectrum of different lipid molecules, including diacylglycerol, phosphatidic acid, sphingomyelin, phosphatidylcholine, phosphatidylinositol, phosphatidylglycerol, cerebroside and phosphatidyl ethanolamine. Plays an important role in HDL remodeling which involves modulating the size and composition of HDL. Also plays a key role in the uptake of cholesterol from peripheral cells and tissues that is subsequently transported to the liver for degradation and excretion. Two distinct forms of PLTP exist in plasma: an active form that can transfer phosphatidylcholine from phospholipid vesicles to HDL, and an inactive form that lacks this capability[1][2][3][4][5][6][7].
-
Subcellular Localization
Secreted; Nucleus
-
Expression
Tissue_specificity:Widely expressed. Highest level of expression in the ovary, thymus and placenta, with moderate levels found in the pancreas, small intestine, testis, lung and prostrate. Low level expression in the kidney, liver and spleen, with very low levels found in the heart, colon, skeletal muscle, leukocytes and brain. Expressed in the cortical neurons -
Isoforms & Post-Translational Modification
P55058 has 4 isomers: P55058-1: 54739 Da (predicted); P55058-2: 49272 Da (predicted); P55058-3: 44135 Da (predicted); P55058-4: 44847 Da (predicted).
Glycosylation is necessary for secretion and its phospholipid transfer activity -
SwissProt ID
-
Synonyms
BPIFE; HDLCQ9; OD107; Pltp
-
Research Field
Cardiovascular
Documentation
[1]. Oka T, et al. Distribution of phospholipid transfer protein in human plasma: presence of two forms of phospholipid transfer protein, one catalytically active and the other inactive. J Lipid Res. 2000 Oct;41(10):1651-7. [Content Brief]
[2]. Vuletic S, et al. PLTP is present in the nucleus, and its nuclear export is CRM1-dependent. Biochim Biophys Acta. 2009 Mar;1793(3):584-91. [Content Brief]
[3]. Albers JJ, et al. Impact of site-specific N-glycosylation on cellular secretion, activity and specific activity of the plasma phospholipid transfer protein. Biochim Biophys Acta. 2011 Jul;1814(7):908-11. [Content Brief]
[4]. Zhang M, et al. Structural basis of the lipid transfer mechanism of phospholipid transfer protein (PLTP). Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1082-1094. [Content Brief]
[5]. Albers JJ, et al. Functional expression of human and mouse plasma phospholipid transfer protein: effect of recombinant and plasma PLTP on HDL subspecies. Biochim Biophys Acta. 1995 Aug 24;1258(1):27-34. [Content Brief]
[6]. Rao R, et al. Molecular and macromolecular specificity of human plasma phospholipid transfer protein. Biochemistry. 1997 Mar 25;36(12):3645-53. [Content Brief]
[7]. Albers JJ, et al. Role of plasma phospholipid transfer protein in lipid and lipoprotein metabolism. Biochim Biophys Acta. 2012 Mar;1821(3):345-57. [Content Brief]
Powered by Bioz
