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SLC37A1 - solute carrier family 37 member 1 Gene

Also Known as G3PP; SPX1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54020

About SLC37A1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,499,622-42,581,426 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 12 paralogues. Broad expression in duodenum (RPKM 9.6), small intestine (RPKM 8.6) and 23 other tissues.

Summary

The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SLC37A1 Products (2)

mRNA	Protein	Name
NM_001320537.2	NP_001307466.1	glucose-6-phosphate exchanger SLC37A1
NM_018964.4	NP_061837.3	glucose-6-phosphate exchanger SLC37A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables glucose 6-phosphate:phosphate antiporter activity	EXP EXP: Inferred from Experiment	21949678	GOA
enables glucose 6-phosphate:phosphate antiporter activity	IDA IDA: Inferred from direct assay	21949678	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in glucose-6-phosphate transport	IDA IDA: Inferred from direct assay	21949678	GOA
involved in phosphate ion transmembrane transport	IDA IDA: Inferred from direct assay	21949678	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	21949678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC37A1 Protein Structure

MFS_1

0
100
200
300
400
500
533 a.a.

Protein Preferred Names	Protein Names
glucose-6-phosphate exchanger SLC37A1	G-3-P permease

Related Diseases

Diseases	Alias
Glycerol Kinase Deficiency	Hyperglycerolemia GKD Gk Deficiency Gk1 Deficiency Deficiency Of Glycerol Kinase Isolated Glycerol Kinase Deficiency Glycerol Kinase Deficiency, Adult Form Glycerol Kinase Deficiency, Juvenile Form Deficiency, Glycerol Kinase
Severe Congenital Neutropenia 4	Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency Scn4 Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome Dursun Syndrome Severe Congenital Neutropenia Type 4
Deafness, Autosomal Recessive 8	Neurosensory Nonsyndromic Recessive Deafness 8 DFNB8 Dfnb10 Deafness, Autosomal Recessive 10 Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8 Nsrd8 Autosomal Recessive Nonsyndromic Deafness 8 Deafness, Autosomal Recessive 8/10 Autosomal Recessive Deafness 10 Autosomal Recessive Deafness 8 Childhood-Onset Neurosensory Autosomal Recessive Deafness 8 Nrsd8 Deafness, Autosomal Recessive, 8 Childhood-Onset Neurosensory Deafness Autosomal Recessive 8 Deafness Autosomal Recessive 10 Deafness Autosomal Recessive 8/10 Deafness Neurosensory Autosomal Recessive 8 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8 Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8 Deafness, Autosomal Recessive, Type 8/10
Glycogen Storage Disease	Glycogenosis Glycogenoses Gsd Storage Disease, Glycogen Gsd - [Glycogen Storage Disease] Glycogen Thesaurismosis Diffuse Glycogenosis Generalised Glycogen Storage Disease Generalised Glycogenosis Generalised Glycogen Storage Disease Of Infants Glycogen Synthase Deficiency
Glycogen Storage Disease Ia	Von Gierke Disease Glycogen Storage Disease Type I Glycogen Storage Disease I Hepatorenal Form Of Glycogen Storage Disease Hepatorenal Glycogenosis Glucose-6-Phosphatase Deficiency Glycogen Storage Disease, Type I Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia GSD1A Gsd1 Von Gierke'S Disease Glycogen Storage Disease Type 1a Glycogen Storage Disease 1a Glucose-6-Phosphate Transport Defect Gsd Ia Deficiency Of Glucose-6-Phosphatase Glycogenosis Type I Glucose-6-Phosphatase Deficiency Glycogen Storage Disease Glycogenosis Type 1 Glucose-6-Phosphate Deficiency Gsd I Gsd Type I G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type 1a Gsd Due To G6p Deficiency Type Ia Gsd Type 1a Gsdia Glycogen Storage Disease Due To G6p Deficiency Type Ia Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia Glycogenosis Type Ia Gsd-Ia Storage Disease, Glycogen, Type 1a Glycogen Storage Disease Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13213	SLC37A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18882	Slc37a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC37A1	MGD	MGI:2446181
Rattus norvegicus	SLC37A1	RGD	RGD:1308587
Felis catus	SLC37A1	VGNC	VGNC:97631
Bos taurus	SLC37A1	VGNC	VGNC:34842
Canis familiaris	SLC37A1	VGNC	VGNC:46386
Macaca mulatta	SLC37A1	VGNC	VGNC:81573
Others	SLC37A1	NCBI