SLC37A1 - solute carrier family 37 member 1 Gene

Homo sapiens

Also known as G3PP; SPX1

Gene ID: 54020 | Gene type: protein coding

About SLC37A1

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:42,499,622-42,581,426 (from NCBI)

This gene has 9 transcripts (splice variants), 270 orthologues and 12 paralogues. Broad expression in duodenum (RPKM 9.6), small intestine (RPKM 8.6) and 23 other tissues.

Summary

The protein encoded by this gene localizes to the endoplasmic reticulum (ER) membrane. This protein translocates glucose-6-phosphate from the cytoplasm into the lumen of the ER for hydrolysis into glucose by another ER membrane protein. This gene is a member of the solute carrier 37 gene family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]

SLC37A1 Products(2)

mRNA	Protein	Name
NM_001320537.2	NP_001307466.1	glucose-6-phosphate exchanger SLC37A1
NM_018964.4	NP_061837.3	glucose-6-phosphate exchanger SLC37A1

SLC37A1 Protein Structure

MFS_1

0
100
200
300
400
500
533 a.a.

Protein Preferred Names

Protein Names

glucose-6-phosphate exchanger SLC37A1

G-3-P permease

Related Diseases

Diseases

Alias

Glycerol Kinase Deficiency

Hyperglycerolemia	GKD
Gk Deficiency	Gk1 Deficiency
Deficiency Of Glycerol Kinase	Isolated Glycerol Kinase Deficiency
Glycerol Kinase Deficiency, Adult Form	Glycerol Kinase Deficiency, Juvenile Form
Deficiency, Glycerol Kinase

Severe Congenital Neutropenia 4

Autosomal Recessive Severe Congenital Neutropenia Due To G6pc3 Deficiency	Scn4
Severe Congenital Neutropenia-Pulmonary Hypertension-Superficial Venous Angiectasis Syndrome	Dursun Syndrome
Severe Congenital Neutropenia Type 4

Deafness, Autosomal Recessive 8

Neurosensory Nonsyndromic Recessive Deafness 8	DFNB8
Dfnb10	Deafness, Autosomal Recessive 10
Deafness, Childhood-Onset Neurosensory, Autosomal Recessive 8	Nsrd8
Autosomal Recessive Nonsyndromic Deafness 8	Deafness, Autosomal Recessive 8/10
Autosomal Recessive Deafness 10	Autosomal Recessive Deafness 8
Childhood-Onset Neurosensory Autosomal Recessive Deafness 8	Nrsd8
Deafness, Autosomal Recessive, 8	Childhood-Onset Neurosensory Deafness Autosomal Recessive 8
Deafness Autosomal Recessive 10	Deafness Autosomal Recessive 8/10
Deafness Neurosensory Autosomal Recessive 8	Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 8
Non-Syndromic Sensorineural Deafness Autosomal Recessive Type 8	Deafness, Autosomal Recessive, Type 8/10

Glycogen Storage Disease

Glycogenosis	Glycogenoses
Gsd	Storage Disease, Glycogen
Gsd - [Glycogen Storage Disease]	Glycogen Thesaurismosis
Diffuse Glycogenosis	Generalised Glycogen Storage Disease
Generalised Glycogenosis	Generalised Glycogen Storage Disease Of Infants
Glycogen Synthase Deficiency

Glycogen Storage Disease Ia

Von Gierke Disease	Glycogen Storage Disease Type I
Glycogen Storage Disease I	Hepatorenal Form Of Glycogen Storage Disease
Hepatorenal Glycogenosis	Glucose-6-Phosphatase Deficiency
Glycogen Storage Disease, Type I	Glycogen Storage Disease Due To Glucose-6-Phosphatase Deficiency Type Ia
GSD1A	Gsd1
Von Gierke'S Disease	Glycogen Storage Disease Type 1a
Glycogen Storage Disease 1a	Glucose-6-Phosphate Transport Defect
Gsd Ia	Deficiency Of Glucose-6-Phosphatase
Glycogenosis Type I	Glucose-6-Phosphatase Deficiency Glycogen Storage Disease
Glycogenosis Type 1	Glucose-6-Phosphate Deficiency
Gsd I	Gsd Type I
G6p Deficiency Type 1a	Gsd Due To G6p Deficiency Type 1a
Gsd Due To G6p Deficiency Type Ia	Gsd Type 1a
Gsdia	Glycogen Storage Disease Due To G6p Deficiency Type Ia
Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type 1a	Glycogenosis Due To Glucose-6-Phosphatase Deficiency Type Ia
Glycogenosis Type Ia	Gsd-Ia
Storage Disease, Glycogen, Type 1a	Glycogen Storage Disease Type Ia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13213	SLC37A1 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC37A1	MGD	MGI:2446181
Rattus norvegicus	SLC37A1	RGD	RGD:1308587
Felis catus	SLC37A1	VGNC	VGNC:97631
Bos taurus	SLC37A1	VGNC	VGNC:34842
Canis familiaris	SLC37A1	VGNC	VGNC:46386
Macaca mulatta	SLC37A1	VGNC	VGNC:81573

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