WNT4 - Wnt family member 4 Gene

Also Known as WNT-4; SERKAL

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 54361

About WNT4

Cytogenetic location: 1p36.12 Genomic coordinates (GRCh38): 1:22,117,313-22,143,097 (from NCBI)

This gene has 3 transcripts (splice variants), 216 orthologues, 18 paralogues and is associated with 6 phenotypes. Biased expression in skin (RPKM 8.0), ovary (RPKM 4.5) and 13 other tissues.

Summary

The Wnt gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is a member of the Wnt gene family, and is the first signaling molecule shown to influence the sex-determination cascade. It encodes a protein which shows 98% amino acid identity to the Wnt4 protein of mouse and rat. This gene and a nuclear receptor known to antagonize the testis-determining factor play a concerted role in both the control of female development and the prevention of testes formation. This gene and another two family members, WNT2 and WNT7B, may be associated with abnormal proliferation in breast tissue. Mutations in this gene can result in Rokitansky-Kuster-Hauser syndrome and in SERKAL syndrome. [provided by RefSeq, Jul 2008]

WNT4 Products (1)

mRNA	Protein	Name
NM_030761.5	NP_110388.2	protein Wnt-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables receptor ligand activity	IDA IDA: Inferred from direct assay	16959810	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adrenal gland development	IEP IEP: Inferred from expression pattern	12844346	GOA
involved in canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	15317892	GOA
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	15040835	GOA
involved in epithelial to mesenchymal transition	IEP IEP: Inferred from expression pattern	12841867	GOA
involved in female sex determination	IMP IMP: Inferred from mutant phenotype	11283799	GOA
involved in kidney development	IEP IEP: Inferred from expression pattern	15312687	GOA
involved in liver development	IEP IEP: Inferred from expression pattern	15312687	GOA
involved in male gonad development	IEP IEP: Inferred from expression pattern	17848411	GOA
involved in male gonad development	IMP IMP: Inferred from mutant phenotype	11283799	GOA
involved in mammary gland epithelium development	IEP IEP: Inferred from expression pattern	8168088	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	12949260	GOA
involved in negative regulation of androgen biosynthetic process	IDA IDA: Inferred from direct assay	16959810	GOA
involved in negative regulation of gene expression	IDA IDA: Inferred from direct assay	15317892	GOA
involved in negative regulation of male gonad development	IMP IMP: Inferred from mutant phenotype	11283799	GOA
involved in negative regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	15317892	GOA
involved in negative regulation of testicular blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	12949260	GOA
involved in negative regulation of testosterone biosynthetic process	IMP IMP: Inferred from mutant phenotype	12949260	GOA
involved in non-canonical Wnt signaling pathway	IDA IDA: Inferred from direct assay	17720811	GOA
involved in paramesonephric duct development	IMP IMP: Inferred from mutant phenotype	18182450	GOA
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	16959810	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	17720811	GOA
involved in positive regulation of aldosterone biosynthetic process	IDA IDA: Inferred from direct assay	16981135	GOA
involved in positive regulation of bone mineralization	IDA IDA: Inferred from direct assay	17720811	GOA
involved in positive regulation of collagen biosynthetic process	IDA IDA: Inferred from direct assay	17720811	GOA
involved in positive regulation of cortisol biosynthetic process	IDA IDA: Inferred from direct assay	16981135	GOA
involved in positive regulation of dermatome development	IDA IDA: Inferred from direct assay	10654605	GOA
involved in positive regulation of osteoblast differentiation	IDA IDA: Inferred from direct assay	17720811	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16959810	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	16959810	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT4 Protein Structure

wnt

0
100
200
300
351 a.a.

Protein Preferred Names	Protein Names
protein Wnt-4	wingless-type MMTV integration site family, member 4

Recombinant WNT4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P700313	Wnt4 protein, Human (HEK293, C-hFc)	P56705-1 (S23-R351)	≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
46,Xx Sex Reversal With Dysgenesis Of Kidneys, Adrenals, And Lungs	Serkal Syndrome SERKAL Sex Reversion-Kidneys, Adrenal And Lung Dysgenesis Syndrome Sex Reversal, Female, With Dysgenesis Of Kidneys, Adrenals, And Lungs
Mullerian Aplasia And Hyperandrogenism	Mullerian Duct Failure And Hyperandrogenism Wnt4 Deficiency Müllerian Aplasia And Hyperandrogenism Biason-Lauber Syndrome Mayer-Rokitansky-Küster-Hauser-Biason-Lauber Syndrome Mayer-Rokitansky-Küster-Hauser-Like Syndrome Müllerian Duct Failure Wnt4 Müllerian Aplasia Wnt4 Müllerian Aplasia And Ovarian Dysfunction MULLAPL Wnt4 Mullerian Aplasia And Ovarian Dysfunction
Endometriosis	Endometriosis, Site Unspecified Endometrial Ectopia
Amenorrhea	Absence Of Menstruation Amenia
Mayer-Rokitansky-Kuster-Hauser Syndrome	Mrkh Syndrome Rokitansky Syndrome Mullerian Aplasia Mrkh Anomaly Congenital Absence Of Uterus And Vagina Congenital Absence Of The Uterus And Vagina Genital Renal Ear Syndrome Mayer-Rokitansky-Küster-Hauser Syndrome Mullerian Dysgenesis Müllerian Agenesis Rokitansky Kuster Hauser Syndrome MRKH Mullerian Aplasia/Dysgenesis Von Mayer-Rokitansky-Kuster Anomaly Mrk Anomaly Uterus Bipartitus Solidus Rudimentarius Cum Vagina Solida Cauv Mullerian Agenesis Aplasia Of The Mullerian Ducts Mullerian Duct Failure Müllerian Aplasia Rokitansky-Kuster-Hauser Syndrome RKH SYNDROME
46,Xx Sex Reversal	46,Xx Testicular Disorder Of Sex Development 46,Xx Testicular Dsd De La Chapelle Syndrome Srxx Xx, Male Syndrome 46, Xx Testicular Disorders Of Sex Development
Hyperandrogenism	Hyperandrogenization Syndrome
Disorder Of Sexual Development	Disorder Of Sex Development Disorders Of Sex Development Sex Development Disorder Sex Differentiation Disease Dsd Sex Differentiation Disorders
Mullerian Duct Aplasia, Unilateral Renal Agenesis, And Cervicothoracic Somite Anomalies	Murcs Association Mayer-Rokitansky-Kuster-Hauser Syndrome Type 2 Mrkh Syndrome Type 2 Mayer-Rokitansky-Küster-Hauser Syndrome Type 2 MURCS Klippel-Feil Deformity, Conductive Deafness, And Absent Vagina Atypical Mrkh Syndrome Mullerian Duct Aplasia-Renal Dysplasia-Cervical Somite Anomalies Syndrome Mayer-Rokitansky-Kuster-Hauser Syndrome, Type Ii Mrkh, Type Ii Mullerian Duct Aplasia, Unilateral Renal Aplasia, And Cervicothoracic Somite Dysplasia Klippel-Feil Deformity - Conductive Deafness - Absent Vagina Müllerian Aplasia - Renal Aplasia - Cervicothoracic Somite Dysplasia
Hermaphroditism
46,Xy Sex Reversal 2	Dosage-Sensitive Sex Reversal Dss SRXY2 46,Xy Sex Reversal, Dax1-Related 46xy Sex Reversal 2, Dosage-Sensitive 46,Xy Sex Reversal Dax1-Related
Submucous Uterine Fibroid	Submucous Leiomyoma Of Uterus
Renal Hypoplasia
46,Xy Sex Reversal	Swyer Syndrome Pure Gonadal Dysgenesis 46,Xy Gonadal Dysgenesis, Xy Female Type Gonadal Dysgenesis, 46,Xy 46,Xy Cgd 46,Xy Complete Gonadal Dysgenesis 46,Xy Pure Gonadal Dysgenesis 46 Xy Gonadal Dysgenesis 46, Xy Cgd 46, Xy Complete Gonadal Dysgenesis 46, Xy Pure Gonadal Dysgenesis Xy Pure Gonadal Dysgenesis Female With 46,Xy Karyotype Xy Females
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Osteoporosis-Pseudoglioma Syndrome	OPPG Ops Osteoporosis With Pseudoglioma Osteogenesis Imperfecta, Ocular Form Ocular Form Of Osteogenesis Imperfecta Osteogenesis Imperfecta Ocular Form Osteoporosis Pseudoglioma Syndrome Pseudoglioma With Bone Fragility
Ovarian Serous Cystadenofibroma
Persistent Mullerian Duct Syndrome	Persistent Müllerian Duct Syndrome Pmds Persistent Oviduct Syndrome Persistent Muellerian Duct Syndrome Female Genital Ducts In Otherwise Normal Male Hernia Uteri Inguinale Persistent Mullerian Duct Syndrome, Types 1 And 2 Persistent Mullerian Derivatives
Ovarian Gonadoblastoma
Norrie Disease	Atrophia Bulborum Hereditaria Episkopi Blindness Pseudoglioma ND Norrie-Warburg Disease Anderson-Warburg Syndrome Fetal Iritis Syndrome Norrie Syndrome Norrie-Warburg Syndrome Ndp Congenital Progressive Oculo-Acoustico-Cerebral Degeneration Norrie'S Disease Oligophrenia Microphthalmus Pseudoglioma Congenita Whitnall-Norman Syndrome
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Ovarian Serous Adenofibroma
Pseudohermaphroditism	Indeterminate Sex And Pseudohermaphroditism
Renal Hypodysplasia/Aplasia 1	Renal Agenesis Renal Adysplasia Renal Aplasia RHDA1 Hereditary Renal Aplasia Hra Hereditary Urogenital Adysplasia Hypodysplasia/Aplasia, Renal, Type 1 Congenital Absence Of Kidneys Syndrome Congenital Absence Of Kidney Aplastic Kidney
Robinow Syndrome	Acral Dysostosis With Facial And Genital Abnormalities Fetal Face Syndrome Robinow Dwarfism Mesomelic Dwarfism-Small Genitalia Syndrome Robinow-Silverman-Smith Syndrome Costovertebral Segmentation Defect With Mesomelia Covesdem Syndrome Robinow'S Syndrome Robinow-Silverman Syndrome
Exudative Vitreoretinopathy	Familial Exudative Vitreoretinopathy Fevr Criswick-Schepens Syndrome Exudative Vitreoretinopathy, Familial Vitreoretinopathy, Exudative ) Exudative Vitreoretinopathy 1
Premature Menopause	Primary Ovarian Insufficiency Premature Ovarian Failure Hypergonadotropic Hypogonadism Premature Ovarian Insufficiency Menopause - Premature Menopause Praecox Menopause Premature Menopause, Premature Female Hypergonadotropic Hypogonadism Hypergonadotrophic Ovarian Failure Primary Female Hypogonadism Pof - [Premature Ovarian Failure] Ovarian Failure Ovarian Secretion Suppression Ovary Hyposecretion Ovary Secretion Deficiency Premature Menopause Nos
Cakut	Renal Or Urinary Tract Malformation Congenital Anomalies Of Kidney And Urinary Tract Congenital Anomaly Of Kidney And Urinary Tract Congenital Anomalies Of The Kidney And Urinary Tract Kidney And Urinary Tract, Anomalies, Congenital Renal Hypodysplasia, Nonsyndromic, 1
Lipoid Congenital Adrenal Hyperplasia	Congenital Adrenal Hyperplasia Congenital Lipoid Adrenal Hyperplasia Due To Star Deficency Congenital Lipoid Adrenal Hyperplasia Lipoid Cah Lipoid Adrenal Hyperplasia Adrenal Hyperplasia 1 Cah Clah LCAH Adrenal Hyperplasia I Lipoid Hyperplasia, Congenital, Of Adrenal Cortex With Male Pseudohermaphroditism Congenital Adrenal Hyperplasia Lipoid Adrenal Hyperplasia, Congenital Congenital Adrenal Hyperplasia, Lipoid AH1 Congenital Lipoid Hyperplasia Of Adrenal Cortex With Male Pseudohermaphroditism Adrenal Hyperplasia Congenital Hyperplasia, Adrenal, Lipoid, Congenital Congenital Adrenogenital Disorders Associated With Enzyme Deficiency Congenital Adrenal Cortical Hyperplasia Congenital Adrenal Gland Hyperplasia Congenital Adrenogenital Syndrome Congenital Hyperadrenocorticism Congenital Adrenogenitalism Congenital Female Adrenal Pseudohermaphroditism
Wilms Tumor 1	Nephroblastoma Wilms Tumor WT1 Wilms' Tumor Bilateral Wilms Tumor Wilms Tumor, Type 1 Wilms Tumor, Somatic Adult Nephroblastoma Wt1 Disorder Renal Embryonic Tumor Adult Kidney Wilms Tumor Childhood Kidney Wilms Tumor Nonanaplastic Kidney Wilms Tumor
Cryptorchidism, Unilateral Or Bilateral	Cryptorchidism Undescended Testicle Undescended Testis Cryptorchism Undescended Testicles CRYPTO Impaired Testicular Descent Cryptosporidiosis Retained Testis Unilateral Cryptorchidism Unilateral Undescended Testis Nondescent Unilateral Testicle Unilateral Cryptorchism Ectopic Testis, Unilateral Bilateral Cryptorchidism Bilateral Cryptorchism Bilateral Nondescent Testicle Bilateral Undescended Testes Bilateral Ectopic Testes

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15836	WNT4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17196	Wnt4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23648	Wnt4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	WNT4	VGNC	VGNC:106530
Bos taurus	WNT4	VGNC	VGNC:36959
Rattus norvegicus	WNT4	RGD	RGD:621348
Felis catus	WNT4	VGNC	VGNC:107690
Canis familiaris	WNT4	VGNC	VGNC:48424
Mus musculus	WNT4	MGD	MGI:98957
Others	WNT4	NCBI