PON3 - paraoxonase 3 Gene

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 5446

About PON3

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:95,359,872-95,396,375 (from NCBI)

This gene has 10 transcripts (splice variants), 269 orthologues, 2 paralogues and is associated with 1 phenotype. Biased expression in liver (RPKM 130.3) and ovary (RPKM 7.4).

Summary

This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the Other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described; however, only one has been fully characterized. [provided by RefSeq, Jul 2008]

PON3 Products (1)

mRNA Protein Name
NM_000940.3 NP_000931.1 serum paraoxonase/lactonase 3

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables acyl-L-homoserine-lactone lactonohydrolase activity IDA
IDA: Inferred from direct assay
15772423 GOA
enables arylesterase activity IDA
IDA: Inferred from direct assay
15772423 GOA
enables protein homodimerization activity IPI
IPI: Inferred from physical interaction
15772423 GOA
Biological Process GO Annotation Evidence References Source
involved in carboxylic acid catabolic process IDA
IDA: Inferred from direct assay
15772423 GOA
involved in lactone catabolic process IDA
IDA: Inferred from direct assay
15772423 GOA
involved in regulation of cellular response to drug IDA
IDA: Inferred from direct assay
15772423 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PON3 Protein Structure

Arylesterase

Arylesterase: Arylesterase (167 - 252)

  • 0
  • 100
  • 200
  • 300
  • 354 a.a.
Protein Preferred Names Protein Names

serum paraoxonase/lactonase 3

  • arylesterase 3

Recombinant PON3 Proteins

Cat. No. Product Name Accession Purity
HY-P74623 PON3 Protein, Human (S50N, sf9, His) Q15166 (M1-L354, S50N) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Amyotrophic Lateral Sclerosis 1

  • Amyotrophic Lateral Sclerosis

  • ALS

  • Lou Gehrig Disease

  • Amyotrophic Lateral Sclerosis Type 1

  • Charcot Disease

  • ALS1

  • Amyotrophic Lateral Sclerosis, Susceptibility To

  • Fals

  • Lou Gehrig'S Disease

  • Mnd

  • Motor Neuron Disease

  • Familial Amyotrophic Lateral Sclerosis

  • Amyotrophic Lateral Sclerosis 1, Familial

  • Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

  • Motor Neuron Disease, Bulbar

  • Motor Neurone Disease

  • Amyotrophic Lateral Sclerosis With Dementia

  • Dementia With Amyotrophic Lateral Sclerosis

  • Motor Neuron Disease, Amyotrophic Lateral Sclerosis

  • Sclerosis, Lateral, Amyotrophic

  • Sclerosis, Lateral, Amyotrophic, Type 1

  • Amyotrophic Sclerosis

  • Als - [Amyotrophic Lateral Sclerosis]

  • Wasting Palsy

  • Amyotrophic Paralysis

  • Amyotrophy Lateral Sclerosis

  • Wasting Paralysis

  • Spinal Progressive Amyotrophy

  • Progressive Atrophic Paralysis
Acute Tympanitis

  • Acute Myringitis
Atherosclerosis Susceptibility

  • Atherosclerosis

  • Atherosclerosis, Susceptibility To

  • ATHS

  • Atherogenic Lipoprotein Phenotype

  • Alp

  • Arteriosclerosis
Persian Gulf Syndrome

  • Gulf War Syndrome
Cardiovascular System Disease

  • Abnormality Of The Cardiovascular System

  • Cardiovascular Disease

  • Disease Of Subdivision Of Hemolymphoid System

  • Disorder Of Cardiovascular System

  • Cardiovascular Diseases
Coronary Heart Disease 1

  • Coronary Heart Disease

  • Coronary Heart Disease, Susceptibility To, 1

  • Chds1

  • Coronary Heart Disease, Susceptibility To

  • CHD

  • Heart, Coronary, Disease, Susceptibility To, Type 1

  • Coronary Arteriosclerosis

  • Coronary Artery Disease
Hemochromatosis, Type 1

  • Hemochromatosis

  • Hemochromatosis Type 1

  • Hereditary Hemochromatosis

  • Hh

  • HFE1

  • Hfe Hemochromatosis, Modifier Of

  • Symptomatic Form Of Classic Hemochromatosis

  • Symptomatic Form Of Hemochromatosis Type 1

  • Symptomatic Form Of Hfe-Related Hereditary Hemochromatosis

  • Haemochromatosis

  • Iron Storage Disorder

  • Bronze Diabetes

  • Hereditary Haemochromatosis

  • Hlah

  • Hfe

  • Hemochromatosis, Hereditary

  • Diabetes Bronze

  • Classic Hemochromatosis

  • Hfe-Associated Hereditary Hemochromatosis

  • Hemochromatosis Classic

  • Bronzed Cirrhosis

  • Familial Hemochromatosis

  • Genetic Hemochromatosis

  • Hc

  • Pigmentary Cirrhosis

  • Primary Hemochromatosis

  • Troisier-Hanot-Chauffard Syndrome

  • Von Recklenhausen-Applebaum Disease

  • Hemochromatosis 1

  • Primary Hereditary Hemochromatosis

  • Bronze Cirrhosis
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS10874 PON3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21411 Pon3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27930 Pon3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus PON3 MGD MGI:106686
Felis catus PON3 VGNC VGNC:68959
Rattus norvegicus PON3 RGD RGD:1302965
Bos taurus PON3 VGNC VGNC:33162
Canis familiaris PON3 VGNC VGNC:44814
Macaca mulatta PON3 VGNC VGNC:76221
Others PON3 NCBI