NEURL1B - neuralized E3 ubiquitin protein ligase 1B Gene

Homo sapiens

Also known as neur2; NEURL3; RNF67B; hNeur2

Gene ID: 54492 | Gene type: protein coding

About NEURL1B

Cytogenetic location: 5q35.1 Genomic coordinates (GRCh38): 5:172,641,263-172,691,540 (from NCBI)

This gene has 3 transcripts (splice variants), 189 orthologues and 3 paralogues. Ubiquitous expression in fat (RPKM 15.4), colon (RPKM 11.9) and 23 other tissues.

Summary

Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in ubiquitin-dependent endocytosis. Located in actin Cytoskeleton and cytosol. [provided by Alliance of Genome Resources, Apr 2022]

NEURL1B Products(3)

mRNA	Protein	Name
NM_001142651.3	NP_001136123.1	E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2
NM_001308177.2	NP_001295106.1	E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR1
NM_001308178.2	NP_001295107.1	E3 ubiquitin-protein ligase NEURL1B isoform hNEUR2-deltaNHR2

NEURL1B Protein Structure

Neuralized

zf-C3HC4_3

0
100
200
300
400
500
555 a.a.

Protein Preferred Names

Protein Names

E3 ubiquitin-protein ligase NEURL1B

E3 ubiquitin-protein ligase NEURL3

Related Diseases

Diseases

Alias

Aortic Valve Disease 1

Aortic Valve Disease	Bicuspid Aortic Valve
Aortic Valve Disorder	AOVD1
Bav	Bicuspid Aortic Valve Disease
Familial Bicuspid Aortic Valve	Aortic Valve Calcification
Aovd	Aortic Valve, Bicuspid
Aortic Valve, Calcification Of	Aortic Stenosis, Calcific
Familial Bav	Calcific Aortic Stenosis
Calcification Of Aortic Valve	Abnormality Of The Aortic Valve
Aortic Valve Disease, Type 1	Aortic Valve Disease 2
Bicommissural Aortic Valve

Spondylocostal Dysostosis 1, Autosomal Recessive

Jarcho-Levin Syndrome	SCDO1
Vertebral Anomalies	Spondylothoracic Dysplasia
Costovertebral Dysplasia	Spondylothoracic Dysostosis
Spondylocostal Dysostosis 1	Autosomal Recessive Spondylocostal Dysostosis 1
Spondylocostal Dysostosis, Autosomal Recessive, 1	Doid:0112365
Dysostosis, Spondylocostal, Autosomal Recessive, Type 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09220	NEURL1B Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	NEURL1B	VGNC	VGNC:49893
Mus musculus	NEURL1B	MGD	MGI:3643092
Felis catus	NEURL1B	VGNC	VGNC:63782
Rattus norvegicus	NEURL1B	RGD	RGD:1564984
Macaca mulatta	NEURL1B	VGNC	VGNC:75292
Bos taurus	NEURL1B	VGNC	VGNC:32014

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