2. Gene
  3. PCDH18 - protocadherin 18 Gene

PCDH18 - protocadherin 18 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as PCDH68L

Gene ID: 54510 | Gene type: protein coding

About PCDH18

Cytogenetic location: 4q28.3 Genomic coordinates (GRCh38): 4:137,518,918-137,532,494 (from NCBI)

This gene has 8 transcripts (splice variants), 274 orthologues and 61 paralogues. Broad expression in placenta (RPKM 18.1), endometrium (RPKM 17.7) and 21 other tissues.

Summary

This gene belongs to the protocadherin gene family, a subfamily of the cadherin superfamily. This gene encodes a protein which contains 6 extracellular cadherin domains, a transmembrane domain and a cytoplasmic tail differing from those of the classical Cadherins. Although its specific function is undetermined, the cadherin-related neuronal receptor is thought to play a role in the establishment and function of specific cell-cell connections in the brain. [provided by RefSeq, Jul 2008]

PCDH18 Products(2)

mRNA Protein Name
NM_001300828.2 NP_001287757.1 protocadherin-18 isoform 2 precursor
NM_019035.5 NP_061908.1 protocadherin-18 isoform 1 precursor

PCDH18 Protein Structure

Cadherin_2

Cadherin_2: Cadherin-like (29 - 111)

Cadherin

Cadherin: Cadherin domain (144 - 236)

Cadherin

Cadherin: Cadherin domain (252 - 344)

Cadherin

Cadherin: Cadherin domain (371 - 455)

Cadherin

Cadherin: Cadherin domain (470 - 566)

Cadherin

Cadherin: Cadherin domain (588 - 672)

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  • 1135 a.a.
Protein Preferred Names Protein Names

protocadherin-18

protocadherin 68-like protein

Recombinant PCDH18 Proteins

Cat. No. Product Name Accession Purity
HY-P79322 Protocadherin-18 Protein, Human (CHO, His) Q9HCL0 (K28-S699) ≥95%

Related Diseases

Diseases Alias
Patent Foramen Ovale

Atrial Septal Defect Within Oval Fossa

Foramen Ovale Patent

Ostium Secundum Atrial Septal Defect

Atrial Septal Defect, Ostium Secundum Type

Foramen Ovale, Patent

Defect, Patent Or Persistent, Ostium Secundum

Ostium Secundum Type Atrial Septal Defect

Persistent Ostium Secundum

Asd Ostium Secundum Type

Ostium Secundum Asd

Osasd

Asd, Ostium Secundum Type

Pfo - [Patent Foramen Ovale]

Open Foramen Ovale

Open Oval Foramen

Persistent Foramen Ovale

Secundum Atrial Septal Defect
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10127 PCDH18 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus PCDH18 RGD RGD:1305870
Bos taurus PCDH18 VGNC VGNC:32619
Canis familiaris PCDH18 VGNC VGNC:44296
Macaca mulatta PCDH18 VGNC VGNC:75600
Mus musculus PCDH18 MGD MGI:1920423
Felis catus PCDH18 VGNC VGNC:64061